Results 51 to 60 of about 10,588,993 (295)

Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine [PDF]

, 2010
Coordination between cell fate specification and cell cycle control in multicellular organisms is essential to regulate cell numbers in tissues and organs during development, and its failure may lead to oncogenesis.
Segref, Alexandra, Johnstone, Iain L., Cabello, Juan, Ralf Schnabel, Iain L. Johnstone, Alexandra Segref, Caroline Clucas, Juan Cabello, Schnabel, Ralf, Clucas, Caroline   +9 more
core   +1 more source

Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins

eLife, 2017
Ubiquilins (Ubqlns) are a family of ubiquitin receptors that promote the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for degradation.
Alexandra M Whiteley, Miguel A Prado, Ivan Peng, Alexander R Abbas, Benjamin Haley, Joao A Paulo, Mike Reichelt, Anand Katakam, Meredith Sagolla, Zora Modrusan, Dong Yun Lee, Merone Roose-Girma, Donald S Kirkpatrick, Brent S McKenzie, Steven P Gygi, Daniel Finley, Eric J Brown   +16 more
doaj   +1 more source

Oscillatory dynamics of cell cycle proteins in single yeast cells analyzed by imaging cytometry. [PDF]

PLoS ONE, 2011
Progression through the cell division cycle is orchestrated by a complex network of interacting genes and proteins. Some of these proteins are known to fluctuate periodically during the cell cycle, but a systematic study of the fluctuations of a broad ...
David A Ball, Julie Marchand, Magaly Poulet, William T Baumann, Katherine C Chen, John J Tyson, Jean Peccoud   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase [PDF]

, 2014
Upon DNA damage, cell cycle progression is temporally blocked to avoid propagation of mutations. While transformed cells largely maintain the competence to recover from a cell cycle arrest, untransformed cells past the G1/S transition lose mitotic ...
Jaiswal, H., Mullers, E, Cascales, H.S., Cascales, HS, Lindqvist, A., Jaiswal, H, Saurin, AT, Lindqvist, A,, Müllers, E., Saurin, A.T.; id_orcid   +9 more
core   +1 more source

Phasing in on the cell cycle

Cell Division, 2018
Just like all matter, proteins can also switch between gas, liquid and solid phases. Protein phase transition has claimed the spotlight in recent years as a novel way of how cells compartmentalize and regulate biochemical reactions.
Steven Boeynaems, Peter Tompa, Ludo Van Den Bosch   +2 more
doaj   +1 more source

A quantitative study of the division cycle of Caulobacter crescentus stalked cells. [PDF]

PLoS Computational Biology, 2008
Progression of a cell through the division cycle is tightly controlled at different steps to ensure the integrity of genome replication and partitioning to daughter cells. From published experimental evidence, we propose a molecular mechanism for control
Shenghua Li, Paul Brazhnik, Bruno Sobral, John J Tyson   +3 more
doaj   +1 more source

Novel Therapies for Tongue Squamous Cell Carcinoma Patients with High-Grade Tumors

Life, 2021
Background: Tongue squamous cell carcinoma (TSCC) patients with high-grade tumors usually suffer from high occurrence and poor prognosis. The current study aimed at finding the biomarkers related to tumor grades and proposing potential therapies by these
Yinghua Li, Hao Lin, Lu Chen, Zihao Chen, Weizhong Li   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Insights into the activation mechanism of PopA, a cyclic di-GMP effector protein involved in cell cycle and development of "Caulobacter Crescentus" [PDF]

, 2012
In Caulobacter crescentus, a complex network integrating cyclic di-GMP and Phosphorylation-dependent signals controls the proteolysis of key regulatory proteins to drive cell cycle and polar morphogenesis.
Schalch-Moser, Annina Larissa
core   +1 more source