Results 71 to 80 of about 1,866,493 (305)

Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis [PDF]

, 2013
Translation mechanisms at different stages of the cell cycle have been studied for many years, resulting in the dogma that translation rates are slowed during mitosis, with cap-independent translation mechanisms favored to give expression of key ...
Abbie Mead, Bonneau, Bradley, Bushell, Byrd, Carmena, Clemens, Coldwell, Coldwell, Coldwell, Dobrikov, Elia, Fadden, Fan, Franz-Wachtel, Gingras, Gingras, Gradi, Harrison, Heesom, Heesom, Hinton, Jackson, Jang, Joanne Cowan, Kim, Laplante, Lisa Perry, Ma, Margalit, Marissen, Mark Coldwell, Mark Willett, Markete Vlasak, Morley, Morris, Nagano, Pasquier, Perez, Proud, Pyronnet, Pyronnet, Qin, Qin, Shevchenko, Simon Morley, Singh, Skop, Smith, Sonenberg, Tinton, Vassilev, Wek, Whitfield, Wurzenberger, Xue   +55 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Obatoclax and Paclitaxel Synergistically Induce Apoptosis and Overcome Paclitaxel Resistance in Urothelial Cancer Cells [PDF]

, 2018
Paclitaxel is a treatment option for advanced or metastatic bladder cancer after the failure of first-line cisplatin and gemcitabine, although resistance limits its clinical benefits.
Flores, M. Luz, Gasca Bellido, Jessica María, Japón Rodríguez, Miguel Ángel, Jiménez Guerrero, Rocío, Medina, Rafael, Pérez Valderrama, Begoña, Romero Portillo, Francisco, Tortolero García, María Dolores   +7 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

CCNA2 and CCNB3 as Early Potential Molecular Candidates of Oocyte Maturation in Cumulus-Oophorous Complex Cells from Follicular Fluid

Diagnostics
Background/Objectives: Oocyte maturation is a process involving both nuclear and cytoplasmic development regulated by epigenetic changes in gene expression.
Nergis Özlem Kılıç, Çağrı Öner, Duygu Kütük, Belgin Selam, İbrahim Orçun Olcay, Ertuğrul Çolak   +5 more
doaj   +1 more source

Depletion of the SR-Related Protein TbRRM1 Leads to Cell Cycle Arrest and Apoptosis-Like Death in Trypanosoma brucei. [PDF]

PLoS ONE, 2015
Arginine-Serine (RS) domain-containing proteins are RNA binding proteins with multiple functions in RNA metabolism. In mammalian cells this group of proteins is also implicated in regulation and coordination of cell cycle and apoptosis.
Gabriela V Levy, Carolina P Bañuelos, Analía G Níttolo, Gastón E Ortiz, Nicolás Mendiondo, Georgina Moretti, Valeria S Tekiel, Daniel O Sánchez   +7 more
doaj   +1 more source

The candidate tumor suppressor gene ECRG4 inhibits cancer cells migration and invasion in esophageal carcinoma [PDF]

, 2010
Background The esophageal cancer related gene 4 (ECRG4) was initially identified and cloned in our laboratory from human normal esophageal epithelium (GenBank accession no.AF325503).
Linwei Li, Chunpeng Zhang, Xiaoyan Li, ShihHsin Lu, Yun Zhou   +4 more
core   +1 more source

Alterations in cell cycle profile and cell cycle protein expression in neuroblastoma cells stably transfected with tau protein [PDF]

BMC Neuroscience, 2007
Alzheimer's disease is characterized by extracellular deposition of beta amyloid peptide and intracellular deposition of hyperphosphorylated tau protein in isocortical brain areas. Recently, we and others have shown that vulnerable neurons or tau aggregate-bearing neurons aberrantly express cell cycle proteins namely cdk inhibitors. In order to analyse
Otto Tobias, Haase Cathleen, Stieler Jens, Albrecht Franziska, Holzer Max, Arendt Thomas   +5 more
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source