Results 21 to 30 of about 68,825 (297)

Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature. [PDF]

, 2005
Trypanosomatids are an ancient family that diverged from the main eukaryotic lineage early in evolution, which display several unique features of gene organization and expression.
Bromley, Elizabeth V, Obado, Samson O, Wilkinson, Shane R, Kelly, John M, Taylor, Martin C   +4 more
core   +1 more source

Recent insights into mechanisms preventing ectopic centromere formation

Open Biology, 2021
The centromere is a specialized chromosomal structure essential for chromosome segregation. Centromere dysfunction leads to chromosome segregation errors and genome instability.
Qianhua Dong, Jinpu Yang, Jinxin Gao, Fei Li   +3 more
doaj   +1 more source

Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target [PDF]

, 2011
The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Yuan, Juping, Louwen, Frank, Sanhaji, Mourad, Friel, Claire T., Wordeman, Linda   +4 more
core   +1 more source

De Novo Centromere Formation and Centromeric Sequence Expansion in Wheat and its Wide Hybrids. [PDF]

PLoS Genetics, 2016
Centromeres typically contain tandem repeat sequences, but centromere function does not necessarily depend on these sequences. We identified functional centromeres with significant quantitative changes in the centromeric retrotransposons of wheat (CRW ...
Xiang Guo, Handong Su, Qinghua Shi, Shulan Fu, Jing Wang, Xiangqi Zhang, Zanmin Hu, Fangpu Han   +7 more
doaj   +1 more source

Epigenetic dynamics of centromeres and neocentromeres in Cryptococcus deuterogattii.

PLoS Genetics, 2021
Deletion of native centromeres in the human fungal pathogen Cryptococcus deuterogattii leads to neocentromere formation. Native centromeres span truncated transposable elements, while neocentromeres do not and instead span actively expressed genes.
Klaas Schotanus, Vikas Yadav, Joseph Heitman   +2 more
doaj   +1 more source

Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi. [PDF]

, 2007
BACKGROUND: Trypanosomes are parasitic protozoa that diverged early from the main eukaryotic lineage. Their genomes display several unusual characteristics and, despite completion of the trypanosome genome projects, the location of centromeric DNA has ...
Bot, Christopher, Nilsson, D,, Nilsson, Daniel, Andersson, B,, Andersson, Bjorn, Bot, C,, Obado, SO, Obado, Samson O, Kelly, JM, Kelly, John M   +9 more
core   +1 more source

Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes [PDF]

, 2010
Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly
Sullivan, Beth A., Sullivan, Beth A, Karen E. Hayden, Kaitlin M. Stimpson, Beth A Sullivan, Bridger Joanna M., Song, IY, Sullivan, BA, Ihn Young Song, Beth A. Sullivan, Karen E Hayden, Hayden, Karen E., Jauch, A, Bridger, Joanna M., Joanna M Bridger, Joanna M. Bridger, Hayden, Karen E, Song Ihn Young, Jauch, Anna, Holtgreve-Grez, Heidi, Heidi Holtgreve-Grez, Holtgreve-Grez Heidi, Stimpson, Kaitlin M, Stimpson, KM, Kaitlin M Stimpson, Anna Jauch, Bridger, JM, Jauch Anna, Bridger, Joanna M, Stimpson Kaitlin M., Sullivan Beth A., Song, Ihn Young, Hayden Karen E., Hayden, KE, Holtgreve-Grez, H, Stimpson, Kaitlin M.   +35 more
core   +2 more sources

Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation. [PDF]

PLoS Genetics, 2018
Centromere is a specialized chromatin domain that plays a vital role in chromosome segregation. In most eukaryotes, centromere is surrounded by the epigenetically distinct heterochromatin domain. Heterochromatin has been shown to contribute to centromere
Jinpu Yang, Siyu Sun, Shu Zhang, Marlyn Gonzalez, Qianhua Dong, Zhongxuan Chi, Yu-Hang Chen, Fei Li   +7 more
doaj   +1 more source

Comparative gene mapping in Arabidopsis lyrata chromosomes 6 and 7 and A thaliana chromosome IV: evolutionary history, rearrangements and local recombination rates [PDF]

, 2006
We have increased the density of genetic markers on the Arabidopsis lyrata chromosomes AL6 and AL7 corresponding to the A. thaliana chromosome IV, in order to determine chromosome rearrangements between these two species, and to compare recombination ...
Hansson, Bengt, Hagenblad, Jenny, Kawabe, Akira, Kawabe, Akira,, Hagenblad, Jenny,, Forrest, Alan,, Charlesworth, Deborah,, Forrest, Alan, Charlesworth, Deborah, Hansson, Bengt,   +9 more
core   +1 more source

Atypical centromeres in plants – what they can tell us

Frontiers in Plant Science, 2015
The centromere, visible as the primary constriction of condensed metaphase chromosomes, is a defined chromosomal locus essential for genome stability. It mediates transient assembly of a multi-protein complex, the kinetochore, which enables interaction ...
Maria eCuacos, Chris eFranklin, Stefan eHeckmann   +2 more
doaj   +1 more source