Evaluation of novel targeted small-molecule therapeutics in desmoplastic small round cell tumor (DSRCT) cells [PDF]
Journal of Cancer Research and Clinical OncologyPurpose Desmoplastic small round cell tumor (DSRCT) is an aggressive sarcoma associated with an extremely poor prognosis. This study evaluates the therapeutic potential of targeted, non-DNA-damaging small-molecule inhibitors in an in vitro DSRCT model ...
Anne Hahn +8 more
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The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization. [PDF]
PLoS Genetics, 2007 In many animal species, the sperm DNA is packaged with male germ line--specific chromosomal proteins, including protamines. At fertilization, these non-histone proteins are removed from the decondensing sperm nucleus and replaced with maternally provided
Emilie Bonnefoy +3 more
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Discover Oncology, 2022 Morphogenesis and organogenesis in the low organisms have been found to be modulated by a number of proteins, and one of such factor, deformed epidermal auto-regulatory factor-1 (DEAF-1) has been initially identified in Drosophila.
Longji Wu +6 more
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Integration host factor of Mycobacterium tuberculosis, mIHF, compacts DNA by a bending mechanism. [PDF]
PLoS ONE, 2013 The bacterial chromosomal DNA is folded into a compact structure called as 'nucleoid' so that the bacterial genome can be accommodated inside the cell.
Arpit Mishra +8 more
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The BRPF1 bromodomain is a molecular reader of di-acetyllysine
Current Research in Structural Biology, 2020 Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans.
Juliet O. Obi +10 more
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Model of a DNA-protein complex of the architectural monomeric protein MC1 from Euryarchaea. [PDF]
PLoS ONE, 2014 In Archaea the two major modes of DNA packaging are wrapping by histone proteins or bending by architectural non-histone proteins. To supplement our knowledge about the binding mode of the different DNA-bending proteins observed across the three domains ...
Françoise Paquet +7 more
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EXPRESSION OF ONCOMARKER PROTEINS IN MAMMARY GLAND TUMOR CELLS IN CATS
Ветеринарная патология, 2022 At the present stage of the study of carcinogenesis, the main mechanism of genetically determined changes leading to uncontrolled cell malignancy is based on molecular research.
V. V. Mitenko, O. V. Dilekova
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Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes. [PDF]
PLoS ONE, 2013 STAT5 proteins are adaptor proteins for histone acetylation enzymes. Histone acetylation at promoter and enhancer chromosomal regions opens the chromatin and allows access of transcription enzymes to specific genes in rapid response cell signals, such as
Erin Garrigan +10 more
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Chromosomes as Sources of Taxonomic Information for Plant Systematics and Evolution [PDF]
Taeckholmia, 2022 Chromosomes are the units of inheritance within the nuclei of all eukaryote cells and carry the genes as DNA packaged in the chromosomes forming the chromatin fibril with histone proteins.
Abdelfattah Badr
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Degradation of RNA during lysis of Escherichia coli cells in agarose plugs breaks the chromosome. [PDF]
PLoS ONE, 2017 The nucleoid of Escherichia coli comprises DNA, nucleoid associated proteins (NAPs) and RNA, whose role is unclear. We found that lysing bacterial cells embedded in agarose plugs in the presence of RNases caused massive fragmentation of the chromosomal ...
Sharik R Khan, Andrei Kuzminov
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