Results 21 to 30 of about 11,541,999 (289)

Interaction of HP1 and Brg1/Brm with the Globular Domain of Histone H3 Is Required for HP1-Mediated Repression [PDF]

, 2009
The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. These proteins contain two related domains known as the chromo- and the chromoshadow-domain.
Fan Hua-Ying, Kingston Robert E., Violaine Saint-André, Christian Muchardt, Saint-Andre, Violaine, Imhof Axel, Batsché Eric, Jang Suk Min, Kingston, Robert E., Saliha Azebi, Robert E Kingston, Axel Imhof, Jang, Suk Min, Eskeland, Ragnhild, Eskeland Ragnhild, Muchardt Christian, Eric Batsché, Azebi Saliha, Fan, Hua-Ying, Muchardt, Christian, Batsche, Eric, Hua-Ying Fan, Marc Lavigne, Ragnhild Eskeland, Saint-André Violaine, Imhof, Axel, Lavigne, Marc, Azebi, Saliha, Suk Min Jang, Lavigne Marc   +29 more
core   +2 more sources

Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway.

PLoS Genetics, 2008
Large numbers of gross chromosomal rearrangements (GCRs) are frequently observed in many cancers. High mobility group 1 (HMG1) protein is a non-histone DNA-binding protein and is highly expressed in different types of tumors.
Nilabja Sikdar, Soma Banerjee, Han Zhang, Stephanie Smith, Kyungjae Myung   +4 more
doaj   +1 more source

Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. [PDF]

, 2012
Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several histone methyltransferases have been
Guan, Yinghua, Rajendran, Anbazhagan, Jagesh V. Shah (116400), Anyong Xie (116396), Gunnar Schotta (116394), Anbazhagan Rajendran (116388), Yinghua Guan (116385), Anyong Xie, Yinghua Guan, Ralph Scully, Hartlerode, Andrea J., Andrea J Hartlerode, Anbazhagan Rajendran, Gunnar Schotta, Andrea J. Hartlerode, Jagesh V. Shah, Jagesh V Shah, Andrea J. Hartlerode (116383), Ralph Scully (116402), Xie, Anyong, Shah, Jagesh, Ura, Kiyoe, Kiyoe Ura (116391), Scully, Ralph, Kiyoe Ura, Schotta, Gunnar, Shah, Jagesh V.   +26 more
core   +2 more sources

c-Myc-Induced Extrachromosomal Elements Carry Active Chromatin

Neoplasia: An International Journal for Oncology Research, 2003
Murine Pre-13 lymphocytes with experimentally activated MycER show both chromosomal and extrachromosomal gene amplification. In this report, we have elucidated the size, structure, functional components of c-Myc-induced extrachromosomal elements (EEs ...
Greg Smith, Cheryl Taylor-Kashton, Len Dushnicky, Stephen Symons, Jim Wright, Sabine Mai   +5 more
doaj   +1 more source

CenH3 distribution reveals extended centromeres in the model beetle Tribolium castaneum.

PLoS Genetics, 2020
Centromeres are chromosomal domains essential for kinetochore assembly and correct chromosome segregation. Inconsistent in their underlying DNA sequences, centromeres are defined epigenetically by the presence of the centromere-specific histone H3 ...
Tena Gržan, Evelin Despot-Slade, Nevenka Meštrović, Miroslav Plohl, Brankica Mravinac   +4 more
doaj   +1 more source

Versatile toolbox for high throughput biochemical and functional studies with fluorescent fusion proteins [PDF]

, 2012
Fluorescent fusion proteins are widely used to study protein localization and interaction dynamics in living cells. However, to fully characterize proteins and to understand their function it is crucial to determine biochemical characteristics such as ...
Sandra B. Hake (165089), Antonia Jack (165084), Sandra B Hake, Patricia Wolf, Pichler Garwin, Pichler, Garwin, Hake, Sandra B., Antonia Jack, Wolf Patricia, Garwin Pichler (165082), Jack Antonia, Wolf, Patricia, Jack, Antonia, Hake Sandra B., Garwin Pichler, Patricia Wolf (165088)   +15 more
core   +2 more sources

Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context. [PDF]

PLoS Genetics, 2012
The Drosophila MSL complex mediates dosage compensation by increasing transcription of the single X chromosome in males approximately two-fold. This is accomplished through recognition of the X chromosome and subsequent acetylation of histone H4K16 on X ...
Artyom A Alekseyenko, Joshua W K Ho, Shouyong Peng, Marnie Gelbart, Michael Y Tolstorukov, Annette Plachetka, Peter V Kharchenko, Youngsook L Jung, Andrey A Gorchakov, Erica Larschan, Tingting Gu, Aki Minoda, Nicole C Riddle, Yuri B Schwartz, Sarah C R Elgin, Gary H Karpen, Vincenzo Pirrotta, Mitzi I Kuroda, Peter J Park   +18 more
doaj   +1 more source

Interaction of Non-histone Chromosomal Proteins HMG1 and HMG2 with DNA [PDF]

European Journal of Biochemistry, 1977
Interaction between non-histone protein HMG1 or HMG2 and DNA has been studied by using thermal denaturation and circular dichroism (CD) spectroscopy. We have made the following observations. 1. The binding of each of these two proteins to DNA stabilizes the latter, as shown by an increase in melting temperature of 20 degrees C (from 45 degrees C to ...
S S, Yu, H J, Li, G H, Goodwin, E W, Johns   +3 more
openaire   +2 more sources

Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development [PDF]

, 2001
MBD2 and MBD3 are closely related proteins with consensus methyl-CpG binding domains. MBD2 is a transcriptional repressor that specifically binds to methylated DNA and is a component of the MeCP1 protein complex.
Hendrich, B, Ramsahoye, B, Bird, A, Wilson, V A, Guy, J   +4 more
core   +1 more source

The histone chaperones Nap1 and Vps75 bind histones H3 and H4 in a tetrameric conformation [PDF]

, 2011
Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant ...
Bowman, Andrew, El Mkami, Hassane, Nicola Wiechens, Bowman, A., Vijender Singh, Andrew Bowman, David George Norman, Ward, Richard, Singh, Vijender, Owen-Hughes, Tom; id_orcid, El-Mkami, Hassane, Richard Ward, Hassane El-Mkami, Wiechens, Nicola, Norman, David George, Owen-Hughes, Tom, Tom Owen-Hughes   +16 more
core   +1 more source