Spt2p defines a new transcription-dependent gross chromosomal rearrangement pathway.
PLoS Genetics, 2008 Large numbers of gross chromosomal rearrangements (GCRs) are frequently observed in many cancers. High mobility group 1 (HMG1) protein is a non-histone DNA-binding protein and is highly expressed in different types of tumors.
Nilabja Sikdar +4 more
doaj +1 more source
Mouse non-histone chromosomal protein HMG-14 cDNA sequence
Nucleic Acids Research, 1990 David Landsman +2 more
exaly +4 more sources
c-Myc-Induced Extrachromosomal Elements Carry Active Chromatin
Neoplasia: An International Journal for Oncology Research, 2003 Murine Pre-13 lymphocytes with experimentally activated MycER show both chromosomal and extrachromosomal gene amplification. In this report, we have elucidated the size, structure, functional components of c-Myc-induced extrachromosomal elements (EEs ...
Greg Smith +5 more
doaj +1 more source
CenH3 distribution reveals extended centromeres in the model beetle Tribolium castaneum.
PLoS Genetics, 2020 Centromeres are chromosomal domains essential for kinetochore assembly and correct chromosome segregation. Inconsistent in their underlying DNA sequences, centromeres are defined epigenetically by the presence of the centromere-specific histone H3 ...
Tena Gržan +4 more
doaj +1 more source
Sequence-specific targeting of dosage compensation in Drosophila favors an active chromatin context. [PDF]
PLoS Genetics, 2012 The Drosophila MSL complex mediates dosage compensation by increasing transcription of the single X chromosome in males approximately two-fold. This is accomplished through recognition of the X chromosome and subsequent acetylation of histone H4K16 on X ...
Artyom A Alekseyenko +18 more
doaj +1 more source
DNA Modifications: Function and Applications in Normal and Disease States
Biology, 2014 Epigenetics refers to a variety of processes that have heritable effects on gene expression programs without changes in DNA sequence. Key players in epigenetic control are chemical modifications to DNA, histone, and non-histone chromosomal proteins ...
Vichithra R. B. Liyanage +5 more
doaj +1 more source
Chicken non-histone chromosomal protein HMG-17 cDNA sequence
Nucleic Acids Research, 1987 David Landsman +2 more
exaly +4 more sources
Epigenetics and airways disease
Respiratory Research, 2006 Epigenetics is the term used to describe heritable changes in gene expression that are not coded in the DNA sequence itself but by post-translational modifications in DNA and histone proteins. These modifications include histone acetylation, methylation,
Ito Kazuhiro +3 more
doaj +1 more source
The Methylation Status of DNA in Hepatocellular Carcinoma [PDF]
Minia Journal of Medical Research, 2019 The most common cause of cancer liver is hepatocellular carcinoma (HCC) and it is an important cause of cancer-related death all over the world (Crissien and Frenette, 2014).
Mostafa Mourad +4 more
doaj +1 more source
HMGA2, the architectural transcription factor high mobility group, is expressed in the developing and mature mouse cochlea. [PDF]
PLoS ONE, 2014 Hmga2 protein belongs to the non-histone chromosomal high-mobility group (HMG) protein family. HMG proteins have been shown to function as architectural transcription regulators, facilitating enhanceosome formation on a variety of mammalian promoters ...
Ibtihel Smeti +4 more
doaj +1 more source