Results 31 to 40 of about 12,009,217 (285)

Interaction of Non-histone Chromosomal Proteins HMG1 and HMG2 with DNA [PDF]

European Journal of Biochemistry, 1977
Interaction between non-histone protein HMG1 or HMG2 and DNA has been studied by using thermal denaturation and circular dichroism (CD) spectroscopy. We have made the following observations. 1. The binding of each of these two proteins to DNA stabilizes the latter, as shown by an increase in melting temperature of 20 degrees C (from 45 degrees C to ...
S S, Yu, H J, Li, G H, Goodwin, E W, Johns   +3 more
openaire   +2 more sources

DNA Modifications: Function and Applications in Normal and Disease States

Biology, 2014
Epigenetics refers to a variety of processes that have heritable effects on gene expression programs without changes in DNA sequence. Key players in epigenetic control are chemical modifications to DNA, histone, and non-histone chromosomal proteins ...
Vichithra R. B. Liyanage, Jessica S. Jarmasz, Nanditha Murugeshan, Marc R. Del Bigio, Mojgan Rastegar, James R. Davie   +5 more
doaj   +1 more source

Interaction of HP1 and Brg1/Brm with the Globular Domain of Histone H3 Is Required for HP1-Mediated Repression [PDF]

, 2009
The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. These proteins contain two related domains known as the chromo- and the chromoshadow-domain.
Fan Hua-Ying, Kingston Robert E., Violaine Saint-André, Christian Muchardt, Saint-Andre, Violaine, Imhof Axel, Batsché Eric, Jang Suk Min, Kingston, Robert E., Saliha Azebi, Robert E Kingston, Axel Imhof, Jang, Suk Min, Eskeland, Ragnhild, Eskeland Ragnhild, Muchardt Christian, Eric Batsché, Azebi Saliha, Fan, Hua-Ying, Muchardt, Christian, Batsche, Eric, Hua-Ying Fan, Marc Lavigne, Ragnhild Eskeland, Saint-André Violaine, Imhof, Axel, Lavigne, Marc, Azebi, Saliha, Suk Min Jang, Lavigne Marc   +29 more
core   +2 more sources

Epigenetics and airways disease

Respiratory Research, 2006
Epigenetics is the term used to describe heritable changes in gene expression that are not coded in the DNA sequence itself but by post-translational modifications in DNA and histone proteins. These modifications include histone acetylation, methylation,
Ito Kazuhiro, Ford Paul, Adcock Ian M, Barnes P J   +3 more
doaj   +1 more source

The Methylation Status of DNA in Hepatocellular Carcinoma [PDF]

Minia Journal of Medical Research, 2019
The most common cause of cancer liver is hepatocellular carcinoma (HCC) and it is an important cause of cancer-related death all over the world (Crissien and Frenette, 2014).
Mostafa Mourad, Hind Abdelghany, Mahmoud Elrehany, Salama Abdelreheim, Heba Marey   +4 more
doaj   +1 more source

Proteomic interrogation of human chromatin. [PDF]

, 2011
Chromatin proteins provide a scaffold for DNA packaging and a basis for epigenetic regulation and genomic maintenance. Despite understanding its functional roles, mapping the chromatin proteome (i.e. the "Chromatome") is still a continuing process. Here,
LeRoy, Gary, Christodoulos A Floudas, Floudas, Christodoulos A., Barry M Zee, Garcia, Benjamin A., Richard C Baliban, Baliban, Richard C., Sandra B Hake, Torrente, Mariana P., Zee, Barry M., Hake, Sandra B., Christodoulos A. Floudas, Barry M. Zee, Nicolas L. Young, Mariana P. Torrente, Gary LeRoy, Richard C. Baliban, Sandra B. Hake, Benjamin A. Garcia, Nicolas L Young, Benjamin A Garcia, Young, Nicolas L., Mariana P Torrente, Torrente Mariana P., Zee Barry M., Young Nicolas L., Hake Sandra B., LeRoy Gary, Garcia Benjamin A., Floudas Christodoulos A., Baliban Richard C.   +30 more
core   +2 more sources

Loss of expression of ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN [PDF]

, 2012
Repair of double strand DNA breaks (DSBs) is pivotal in maintaining normal cell division and disruption of this system has been shown to be a key factor in carcinogenesis.
Tomlinson, IP, Presz, M, Oukrif, D, Hodgson, SV, McGregor, M, Fadhil, W, Ilyas, M, Beggs, AD, Midgley, R, Kerr, D, Domingo, E, Johnstone, E, Novelli, M, Abulafi, M   +13 more
core   +3 more sources

HMGA2, the architectural transcription factor high mobility group, is expressed in the developing and mature mouse cochlea. [PDF]

PLoS ONE, 2014
Hmga2 protein belongs to the non-histone chromosomal high-mobility group (HMG) protein family. HMG proteins have been shown to function as architectural transcription regulators, facilitating enhanceosome formation on a variety of mammalian promoters ...
Ibtihel Smeti, Isabelle Watabe, Etienne Savary, Arnaud Fontbonne, Azel Zine   +4 more
doaj   +1 more source

The synergistic interaction between CD20 monoclonal antibodies and Histone Deacetylase inhibitors in B cell Non Hodgkin’s Lymphoma

, 2010
Recent improvements in molecular sub typing of Non Hodgkin’s lymphomashave resulted in targeted therapies becoming incorporated into treatmentparadigms.
Nolan, David Francis Luke
core   +2 more sources

Conformational Studies of Two Non‐histone Chromosomal Proteins and Their Interactions with DNA [PDF]

European Journal of Biochemistry, 1976
The conformational properties of two non-histone chromosomal proteins (high-mobility-group proteins 1 and 2) have been studied by spectroscopic methods. The interaction of high-mobility-group protein 1 with DNA has also been studied. 1. Circular dichroism results indicate that in the presence of salt both proteins are 40-50% helical between pH 1 and 9.
P D, Cary, C, Crane-Robinson, E M, Bradbury, K, Javaherian, G H, Goodwin, E W, Johns   +5 more
openaire   +2 more sources