Results 11 to 20 of about 11,541,999 (289)
Non‐histone Chromosomal Proteins [PDF]
European Journal of Biochemistry, 1975 We describe a method for fractionation of chromatin components by selective dissociation with salt in buffers containing 5 M urea in combination with chromatography on hydroxyapatite at 4 °C. This results in two histone and four non‐histone fractions which are recovered in high yield and with minimal proteolytic contamination.Template capacity ...
Blüthmann, H., Mrozek, S., Gierer, A.
openaire +3 more sources
Degradation of RNA during lysis of Escherichia coli cells in agarose plugs breaks the chromosome. [PDF]
PLoS ONE, 2017 The nucleoid of Escherichia coli comprises DNA, nucleoid associated proteins (NAPs) and RNA, whose role is unclear. We found that lysing bacterial cells embedded in agarose plugs in the presence of RNases caused massive fragmentation of the chromosomal ...
Sharik R Khan, Andrei Kuzminov
doaj +1 more source
PLoS Genetics, 2021 Aberrant repair of DNA double-strand breaks can recombine distant chromosomal breakpoints. Chromosomal rearrangements compromise genome function and are a hallmark of ageing.
David A Ellis +9 more
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SUMO control of centromere homeostasis
Frontiers in Cell and Developmental Biology, 2023 Centromeres are unique chromosomal loci that form the anchorage point for the mitotic spindle during mitosis and meiosis. Their position and function are specified by a unique chromatin domain featuring the histone H3 variant CENP-A.
Sebastiaan J. W. van den Berg +2 more
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The DNA intercalators ethidium bromide and propidium iodide also bind to core histones
FEBS Open Bio, 2014 Eukaryotic DNA is compacted in the form of chromatin, in a complex with histones and other non-histone proteins. The intimate association of DNA and histones in chromatin raises the possibility that DNA-interactive small molecules may bind to chromatin ...
Amrita Banerjee +6 more
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Selfish chromosomal drive shapes recent centromeric histone evolution in monkeyflowers.
PLoS Genetics, 2021 Centromeres are essential mediators of chromosomal segregation, but both centromeric DNA sequences and associated kinetochore proteins are paradoxically diverse across species.
Findley R Finseth +2 more
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PLoS ONE, 2023 Acetylation of lysine residues is an important and common post-translational regulatory mechanism occurring on thousands of non-histone proteins. Lysine deacetylases (KDACs or HDACs) are a family of enzymes responsible for removing acetylation.
Tasha B Toro +4 more
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Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1 [PDF]
, 2010 The histone methyltransferase SU(VAR)3-9 plays an important role in the formation of heterochromatin within the eukaryotic nucleus. Several studies have shown that the formation of condensed chromatin is highly regulated during development, suggesting ...
Johansen Kristen M. +20 more
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Compositional and structural analysis of selected chromosomal domains from Saccharomyces cerevisiae [PDF]
, 2012 In eukaryotic genomes, chromatin is the template of all nuclear processes including transcription, recombination and replication. Besides the wrapping of DNA in nucleosome core particles, eukaryotic chromatin is associated, interpreted and modified by ...
Hamperl, Stephan
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Loss of expression of ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN [PDF]
, 2012 Repair of double strand DNA breaks (DSBs) is pivotal in maintaining normal cell division and disruption of this system has been shown to be a key factor in carcinogenesis.
Tomlinson, IP +13 more
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