Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex [PDF]
, 2012 Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis. Kinetochore assembly is a cell cycle regulated multi-step process.
Bancroft, James M. +14 more
core +11 more sources
Gross Chromosomal Rearrangement at Centromeres
Biomolecules, 2023 Centromeres play essential roles in the faithful segregation of chromosomes. CENP-A, the centromere-specific histone H3 variant, and heterochromatin characterized by di- or tri-methylation of histone H3 9th lysine (H3K9) are the hallmarks of centromere ...
Ran Xu, Ziyi Pan, Takuro Nakagawa
doaj +1 more source
Centromere Repositioning [PDF]
Genome Research, 1999 Primate pericentromeric regions recently have been shown to exhibit extraordinary evolutionary plasticity. In this paper we report an additional peculiar feature of these regions that we discovered while analyzing, by FISH, the evolutionary conservation of primate phylogenetic chromosome IX.
Montefalcone G +3 more
openaire +2 more sources
Centromere size scales with genome size across Eukaryotes
Scientific Reports, 2021 Previous studies on grass species suggested that the total centromere size (sum of all centromere sizes in a cell) may be determined by the genome size, possibly because stable scaling is important for proper cell division. However, it is unclear whether
Klára Plačková +2 more
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Chromosome Y centromere array deletion leads to impaired centromere function. [PDF]
PLoS ONE, 2014 The centromere is an essential chromosomal structure that is required for the faithful distribution of replicated chromosomes to daughter cells. Defects in the centromere can compromise the stability of chromosomes resulting in segregation errors.
Alison N Graham, Paul Kalitsis
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A Taz1- and Microtubule-Dependent Regulatory Relationship between Telomere and Centromere Positions in Bouquet Formation Secures Proper Meiotic Divisions. [PDF]
PLoS Genetics, 2016 During meiotic prophase, telomeres cluster, forming the bouquet chromosome arrangement, and facilitate homologous chromosome pairing. In fission yeast, bouquet formation requires switching of telomere and centromere positions.
Kazuhiro Katsumata +8 more
doaj +1 more source
Dynamic epigenetic states of maize centromeres
Frontiers in Plant Science, 2015 The centromere is a specialized chromosomal region identified as the major constriction, upon which the kinetochore complex is formed, ensuring accurate chromosome orientation and segregation during cell division.
Yalin eLiu +5 more
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Holocentromeres can consist of merely a few megabase-sized satellite arrays
Nature Communications, 2023 The centromere is the chromosome region where microtubules attach during cell division. In contrast to monocentric chromosomes with one centromere, holocentric species usually distribute hundreds of centromere units along the entire chromatid.
Yi-Tzu Kuo +17 more
doaj +1 more source
The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex. [PDF]
, 2019 The inner centromere is a region on every mitotic chromosome that enables specific biochemical reactions that underlie properties, such as the maintenance of cohesion, the regulation of kinetochores and the assembly of specialized chromatin, that can ...
A Chakraborty +57 more
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The architecture of chicken chromosome territories changes during differentiation [PDF]
, 2004 BACKGROUND: Between cell divisions the chromatin fiber of each chromosome is restricted to a subvolume of the interphase cell nucleus called chromosome territory.
Bonifer, C. +7 more
core +4 more sources