Results 31 to 40 of about 87,751 (339)

De Novo Centromere Formation and Centromeric Sequence Expansion in Wheat and its Wide Hybrids. [PDF]

PLoS Genetics, 2016
Centromeres typically contain tandem repeat sequences, but centromere function does not necessarily depend on these sequences. We identified functional centromeres with significant quantitative changes in the centromeric retrotransposons of wheat (CRW ...
Xiang Guo, Handong Su, Qinghua Shi, Shulan Fu, Jing Wang, Xiangqi Zhang, Zanmin Hu, Fangpu Han   +7 more
doaj   +1 more source

Recent insights into mechanisms preventing ectopic centromere formation

Open Biology, 2021
The centromere is a specialized chromosomal structure essential for chromosome segregation. Centromere dysfunction leads to chromosome segregation errors and genome instability.
Qianhua Dong, Jinpu Yang, Jinxin Gao, Fei Li   +3 more
doaj   +1 more source

Linear Assembly of a Human Y Chromosome Centromere

Nature Biotechnology, 2018
The human genome reference sequence remains incomplete owing to the challenge of assembling long tracts of near-identical tandem repeats in centromeres.
Miten Jain, Hugh E. Olsen, D. Turner, D. Stoddart, Kira V. Bulazel, B. Paten, D. Haussler, H. Willard, M. Akeson, K. Miga   +9 more
semanticscholar   +1 more source

Epigenetic dynamics of centromeres and neocentromeres in Cryptococcus deuterogattii.

PLoS Genetics, 2021
Deletion of native centromeres in the human fungal pathogen Cryptococcus deuterogattii leads to neocentromere formation. Native centromeres span truncated transposable elements, while neocentromeres do not and instead span actively expressed genes.
Klaas Schotanus, Vikas Yadav, Joseph Heitman   +2 more
doaj   +1 more source

The inner-centromere is a biomolecular condensate scaffolded by the Chromosomal Passenger Complex

Nature Cell Biology, 2019
The inner centromere is a region on every mitotic chromosome that enables specific biochemical reactions that underlie properties, such as the maintenance of cohesion, the regulation of kinetochores and the assembly of specialized chromatin, that can ...
Prasad D. Trivedi, F. Palomba, E. Niedzialkowska, M. Digman, E. Gratton, P. Stukenberg   +5 more
semanticscholar   +1 more source

Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes [PDF]

, 2010
Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly
Sullivan, Beth A., Sullivan, Beth A, Karen E. Hayden, Kaitlin M. Stimpson, Beth A Sullivan, Bridger Joanna M., Song, IY, Sullivan, BA, Ihn Young Song, Beth A. Sullivan, Karen E Hayden, Hayden, Karen E., Jauch, A, Bridger, Joanna M., Joanna M Bridger, Joanna M. Bridger, Hayden, Karen E, Song Ihn Young, Jauch, Anna, Holtgreve-Grez, Heidi, Heidi Holtgreve-Grez, Holtgreve-Grez Heidi, Stimpson, Kaitlin M, Stimpson, KM, Kaitlin M Stimpson, Anna Jauch, Bridger, JM, Jauch Anna, Bridger, Joanna M, Stimpson Kaitlin M., Sullivan Beth A., Song, Ihn Young, Hayden Karen E., Hayden, KE, Holtgreve-Grez, H, Stimpson, Kaitlin M.   +35 more
core   +1 more source

Centromere Satellite Repeats Have Undergone Rapid Changes in Polyploid Wheat Subgenomes[OPEN]

The Plant Cell, 2019
Variation in centromere satellite sequence and copy number, and structural rearrangements produce asymmetries in polyploid wheat homeologs, highlighting the role in homolog pairing during meiosis. Centromeres mediate the pairing of homologous chromosomes
H. Su, Yalin Liu, Chang Liu, Qinghua Shi, Yuhong Huang, Fang Han   +5 more
semanticscholar   +1 more source

Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi. [PDF]

, 2007
BACKGROUND: Trypanosomes are parasitic protozoa that diverged early from the main eukaryotic lineage. Their genomes display several unusual characteristics and, despite completion of the trypanosome genome projects, the location of centromeric DNA has ...
Bot, Christopher, Nilsson, D,, Nilsson, Daniel, Andersson, B,, Andersson, Bjorn, Bot, C,, Obado, SO, Obado, Samson O, Kelly, JM, Kelly, John M   +9 more
core   +1 more source

Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation. [PDF]

PLoS Genetics, 2018
Centromere is a specialized chromatin domain that plays a vital role in chromosome segregation. In most eukaryotes, centromere is surrounded by the epigenetically distinct heterochromatin domain. Heterochromatin has been shown to contribute to centromere
Jinpu Yang, Siyu Sun, Shu Zhang, Marlyn Gonzalez, Qianhua Dong, Zhongxuan Chi, Yu-Hang Chen, Fei Li   +7 more
doaj   +1 more source

DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres

Nature Cell Biology, 2019
Chromatin assembled with the histone H3 variant CENP-A is the heritable epigenetic determinant of human centromere identity. Using genome-wide mapping and reference models for 23 human centromeres, CENP-A binding sites are identified within the megabase ...
Yael Nechemia-Arbely, K. Miga, Ofer Shoshani, A. Aslanian, Moira A. McMahon, A. Lee, D. Fachinetti, J. Yates, B. Ren, D. Cleveland   +9 more
semanticscholar   +1 more source