The Birth of the Centromere [PDF]
Cell Cycle, 2007 The centromere is the region of the eukaryotic chromosome that determines kinetochore formation and sister chromatid cohesion. Centromeres interact with spindle microtubules to ensure chromatid segregation during mitosis and homologous chromosome segregation during meiosis I.
Alfredo, Villasante +3 more
openaire +2 more sources
Epigenetic dynamics of centromeres and neocentromeres in Cryptococcus deuterogattii.
PLoS Genetics, 2021 Deletion of native centromeres in the human fungal pathogen Cryptococcus deuterogattii leads to neocentromere formation. Native centromeres span truncated transposable elements, while neocentromeres do not and instead span actively expressed genes.
Klaas Schotanus +2 more
doaj +1 more source
Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature. [PDF]
, 2005 Trypanosomatids are an ancient family that diverged from the main eukaryotic lineage early in evolution, which display several unique features of gene organization and expression.
Bromley, Elizabeth V +4 more
core +1 more source
De Novo Centromere Formation and Centromeric Sequence Expansion in Wheat and its Wide Hybrids. [PDF]
PLoS Genetics, 2016 Centromeres typically contain tandem repeat sequences, but centromere function does not necessarily depend on these sequences. We identified functional centromeres with significant quantitative changes in the centromeric retrotransposons of wheat (CRW ...
Xiang Guo +7 more
doaj +1 more source
Recent insights into mechanisms preventing ectopic centromere formation
Open Biology, 2021 The centromere is a specialized chromosomal structure essential for chromosome segregation. Centromere dysfunction leads to chromosome segregation errors and genome instability.
Qianhua Dong +3 more
doaj +1 more source
Repetitive DNA is associated with centromeric domains in Trypanosoma brucei but not Trypanosoma cruzi. [PDF]
, 2007 BACKGROUND: Trypanosomes are parasitic protozoa that diverged early from the main eukaryotic lineage. Their genomes display several unusual characteristics and, despite completion of the trypanosome genome projects, the location of centromeric DNA has ...
Bot, Christopher +14 more
core +1 more source
Centromere Repeats: Hidden Gems of the Genome
Genes, 2019 Satellite DNAs are now regarded as powerful and active contributors to genomic and chromosomal evolution. Paired with mobile transposable elements, these repetitive sequences provide a dynamic mechanism through which novel karyotypic modifications and ...
Gabrielle Hartley, R. O'Neill
semanticscholar +1 more source
Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target [PDF]
, 2011 The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Yuan, Juping +4 more
core +1 more source
Comparative gene mapping in Arabidopsis lyrata chromosomes 6 and 7 and A thaliana chromosome IV: evolutionary history, rearrangements and local recombination rates [PDF]
, 2006 We have increased the density of genetic markers on the Arabidopsis lyrata chromosomes AL6 and AL7 corresponding to the A. thaliana chromosome IV, in order to determine chromosome rearrangements between these two species, and to compare recombination ...
Hansson, Bengt +9 more
core +1 more source
Linear Assembly of a Human Y Chromosome Centromere
Nature Biotechnology, 2018 The human genome reference sequence remains incomplete owing to the challenge of assembling long tracts of near-identical tandem repeats in centromeres.
Miten Jain +9 more
semanticscholar +1 more source