Results 31 to 40 of about 56,644 (246)
Recent insights into mechanisms preventing ectopic centromere formation
Open Biology, 2021 The centromere is a specialized chromosomal structure essential for chromosome segregation. Centromere dysfunction leads to chromosome segregation errors and genome instability.
Qianhua Dong +3 more
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Epigenetic dynamics of centromeres and neocentromeres in Cryptococcus deuterogattii.
PLoS Genetics, 2021 Deletion of native centromeres in the human fungal pathogen Cryptococcus deuterogattii leads to neocentromere formation. Native centromeres span truncated transposable elements, while neocentromeres do not and instead span actively expressed genes.
Klaas Schotanus +2 more
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Atypical centromeres in plants – what they can tell us
Frontiers in Plant Science, 2015 The centromere, visible as the primary constriction of condensed metaphase chromosomes, is a defined chromosomal locus essential for genome stability. It mediates transient assembly of a multi-protein complex, the kinetochore, which enables interaction ...
Maria eCuacos +2 more
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Heterochromatin and RNAi regulate centromeres by protecting CENP-A from ubiquitin-mediated degradation. [PDF]
PLoS Genetics, 2018 Centromere is a specialized chromatin domain that plays a vital role in chromosome segregation. In most eukaryotes, centromere is surrounded by the epigenetically distinct heterochromatin domain. Heterochromatin has been shown to contribute to centromere
Jinpu Yang +7 more
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Sequential assembly of centromeric proteins in male mouse meiosis. [PDF]
PLoS Genetics, 2009 The assembly of the mitotic centromere has been extensively studied in recent years, revealing the sequence and regulation of protein loading to this chromosome domain. However, few studies have analyzed centromere assembly during mammalian meiosis. This
María Teresa Parra +6 more
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Cell Reports, 2021 Summary: Functional tags are ubiquitous in cell biology, and for studies of one chromosomal locus, the centromere, tags have been remarkably useful. The centromere directs chromosome inheritance at cell division. The location of the centromere is defined
Catalina Salinas-Luypaert +6 more
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Key centromere proteins in Physcomitrella patens identified via SPIDER and IP-MS
Shenzhen Daxue xuebao. Ligong banPlant artificial chromosomes play a crucial role in synthetic biology, wherein key centromere proteins represent essential components in synthesizing these chromosomes. However, the identification of centromere proteins in plants remains limited.
LIU Xuedong +3 more
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Epigenetically-inherited centromere and neocentromere DNA replicates earliest in S-phase. [PDF]
PLoS Genetics, 2010 Eukaryotic centromeres are maintained at specific chromosomal sites over many generations. In the budding yeast Saccharomyces cerevisiae, centromeres are genetic elements defined by a DNA sequence that is both necessary and sufficient for function ...
Amnon Koren +5 more
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Epigenetics & Chromatin, 2018 Background The centromere is the specialized chromatin region that directs chromosome segregation. The kinetochore assembles on the centromere, attaching chromosomes to microtubules in mitosis.
Jing Zhu +2 more
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Centromere plasmid: a new genetic tool for the study of Plasmodium falciparum. [PDF]
PLoS ONE, 2012 The introduction of transgenes into Plasmodium falciparum, a highly virulent human malaria parasite, has been conducted either by single crossover recombination or by using episomal plasmids.
Shiroh Iwanaga +3 more
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