Results 51 to 60 of about 92,899 (342)

Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes [PDF]

, 2010
Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly
Sullivan, Beth A., Sullivan, Beth A, Karen E. Hayden, Kaitlin M. Stimpson, Beth A Sullivan, Bridger Joanna M., Song, IY, Sullivan, BA, Ihn Young Song, Beth A. Sullivan, Karen E Hayden, Hayden, Karen E., Jauch, A, Bridger, Joanna M., Joanna M Bridger, Joanna M. Bridger, Hayden, Karen E, Song Ihn Young, Jauch, Anna, Holtgreve-Grez, Heidi, Heidi Holtgreve-Grez, Holtgreve-Grez Heidi, Stimpson, Kaitlin M, Stimpson, KM, Kaitlin M Stimpson, Anna Jauch, Bridger, JM, Jauch Anna, Bridger, Joanna M, Stimpson Kaitlin M., Sullivan Beth A., Song, Ihn Young, Hayden Karen E., Hayden, KE, Holtgreve-Grez, H, Stimpson, Kaitlin M.   +35 more
core   +2 more sources

Key centromere proteins in Physcomitrella patens identified via SPIDER and IP-MS

Shenzhen Daxue xuebao. Ligong ban
Plant artificial chromosomes play a crucial role in synthetic biology, wherein key centromere proteins represent essential components in synthesizing these chromosomes. However, the identification of centromere proteins in plants remains limited.
LIU Xuedong, WONG Yuming, WANG Mingliang, MO Beixin   +3 more
doaj   +1 more source

Sequential assembly of centromeric proteins in male mouse meiosis. [PDF]

PLoS Genetics, 2009
The assembly of the mitotic centromere has been extensively studied in recent years, revealing the sequence and regulation of protein loading to this chromosome domain. However, few studies have analyzed centromere assembly during mammalian meiosis. This
María Teresa Parra, Rocío Gómez, Alberto Viera, Elena Llano, Alberto M Pendás, Julio S Rufas, José A Suja   +6 more
doaj   +1 more source

Point centromere activity requires an optimal level of centromeric noncoding RNA

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Budding yeast harbors a simple point centromere, which is originally believed to be sequence dependent without much epigenetic regulation and is transcription incompatible, as inserting a strong promoter upstream inactivates the centromere ...
Y. Ling, K. Yuen
semanticscholar   +1 more source

The CINs of the centromere [PDF]

Biochemical Society Transactions, 2013
Replication stress is a significant contributor to genome instability. Recent studies suggest that the centromere is particularly susceptible to replication stress and prone to rearrangements and genome damage, as well as chromosome loss. This effect is enhanced by loss of heterochromatin.
openaire   +2 more sources

Epigenetically-inherited centromere and neocentromere DNA replicates earliest in S-phase. [PDF]

PLoS Genetics, 2010
Eukaryotic centromeres are maintained at specific chromosomal sites over many generations. In the budding yeast Saccharomyces cerevisiae, centromeres are genetic elements defined by a DNA sequence that is both necessary and sufficient for function ...
Amnon Koren, Hung-Ji Tsai, Itay Tirosh, Laura S Burrack, Naama Barkai, Judith Berman   +5 more
doaj   +1 more source

Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-AK124ub

Cell Reports, 2021
Summary: Functional tags are ubiquitous in cell biology, and for studies of one chromosomal locus, the centromere, tags have been remarkably useful. The centromere directs chromosome inheritance at cell division. The location of the centromere is defined
Catalina Salinas-Luypaert, Praveen Kumar Allu, Glennis A. Logsdon, Jennine M. Dawicki-McKenna, Craig W. Gambogi, Daniele Fachinetti, Ben E. Black   +6 more
doaj   +1 more source

Transposable elements: genome innovation, chromosome diversity, and centromere conflict

Chromosome Research, 2018
Although it was nearly 70 years ago when transposable elements (TEs) were first discovered “jumping” from one genomic location to another, TEs are now recognized as contributors to genomic innovations as well as genome instability across a wide variety ...
S. Klein, R. O'Neill
semanticscholar   +1 more source

Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing

Nature Communications, 2019
Nucleosomes containing the histone H3 variant CENP-A are the epigenetic mark of centromeres, the kinetochore assembly sites required for chromosome segregation.
D. Pan, Kai Walstein, Annika Take, D. Bier, Nadine Kaiser, A. Musacchio   +5 more
semanticscholar   +1 more source

Centromere detection.

, 2023
Centromere detection using CentO sequences and CentO-based centromere correction distribution for rice chromosomes 3, 7 and 9. The plots on the left show the count of CentO alignments in 100 kb windows for the reference sequence in blue and the query ...
Mauricio Peñuela (7138847), Mathias Lorieux (227994), Camila Riccio-Rengifo (14636791), Jorge Finke (5560520), Anestis Gkanogiannis (3504257), Camilo Rocha (14636794), Rod A. Wing (7852109)   +6 more
core   +1 more source