Results 51 to 60 of about 87,751 (339)

Mechanism of centromere recruitment of the CENP-A chaperone HJURP and its implications for centromere licensing

Nature Communications, 2019
Nucleosomes containing the histone H3 variant CENP-A are the epigenetic mark of centromeres, the kinetochore assembly sites required for chromosome segregation.
D. Pan, Kai Walstein, Annika Take, D. Bier, Nadine Kaiser, A. Musacchio   +5 more
semanticscholar   +1 more source

Fission yeast bub1 is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis [PDF]

, 1998
The spindle checkpoint ensures proper chromosome segregation by delaying anaphase until all chromosomes are correctly attached to the mitotic spindle.
Javerzat, Jean-Paul, Javerzat, J P, Bernard, P, Hardwick, K.G., Hardwick, Kevin, Bernard, Pascal, Pascal Bernard, Jean-Paul Javerzat, Kevin Hardwick   +8 more
core   +1 more source

Key centromere proteins in Physcomitrella patens identified via SPIDER and IP-MS

Shenzhen Daxue xuebao. Ligong ban
Plant artificial chromosomes play a crucial role in synthetic biology, wherein key centromere proteins represent essential components in synthesizing these chromosomes. However, the identification of centromere proteins in plants remains limited.
LIU Xuedong, WONG Yuming, WANG Mingliang, MO Beixin   +3 more
doaj   +1 more source

Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation

Journal of Cell Biology, 2018
Centromeres are essential for chromosome segregation and are specified epigenetically by the presence of the histone H3 variant CENP-A. In flies and humans, replenishment of the centromeric mark is uncoupled from DNA replication and requires the removal ...
G. O. Bobkov, N. Gilbert, P. Heun
semanticscholar   +1 more source

Epigenetically-inherited centromere and neocentromere DNA replicates earliest in S-phase. [PDF]

PLoS Genetics, 2010
Eukaryotic centromeres are maintained at specific chromosomal sites over many generations. In the budding yeast Saccharomyces cerevisiae, centromeres are genetic elements defined by a DNA sequence that is both necessary and sufficient for function ...
Amnon Koren, Hung-Ji Tsai, Itay Tirosh, Laura S Burrack, Naama Barkai, Judith Berman   +5 more
doaj   +1 more source

RNAi is a critical determinant of centromere evolution in closely related fungi

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The “centromere paradox” refers to rapidly evolving and highly diverse centromere DNA sequences even in closely related eukaryotes. However, factors contributing to this rapid divergence are largely unknown.
V. Yadav, Sheng Sun, R. B. Billmyre, B. Thimmappa, Terrance Shea, Robert E. Lintner, G. Bakkeren, Christina A. Cuomo, J. Heitman, K. Sanyal   +9 more
semanticscholar   +1 more source

Histone H3K9 and H4 Acetylations and Transcription Facilitate the Initial CENP-AHCP−3 Deposition and De Novo Centromere Establishment in Caenorhabditis elegans Artificial Chromosomes

Epigenetics & Chromatin, 2018
Background The centromere is the specialized chromatin region that directs chromosome segregation. The kinetochore assembles on the centromere, attaching chromosomes to microtubules in mitosis.
Jing Zhu, Kevin Chi Lok Cheng, Karen Wing Yee Yuen   +2 more
doaj   +1 more source

Centromere plasmid: a new genetic tool for the study of Plasmodium falciparum. [PDF]

PLoS ONE, 2012
The introduction of transgenes into Plasmodium falciparum, a highly virulent human malaria parasite, has been conducted either by single crossover recombination or by using episomal plasmids.
Shiroh Iwanaga, Tomomi Kato, Izumi Kaneko, Masao Yuda   +3 more
doaj   +1 more source

The CINs of the centromere [PDF]

Biochemical Society Transactions, 2013
Replication stress is a significant contributor to genome instability. Recent studies suggest that the centromere is particularly susceptible to replication stress and prone to rearrangements and genome damage, as well as chromosome loss. This effect is enhanced by loss of heterochromatin.
openaire   +2 more sources

Keeping the Centromere under Control: A Promising Role for DNA Methylation

Cells, 2019
In order to maintain cell and organism homeostasis, the genetic material has to be faithfully and equally inherited through cell divisions while preserving its integrity.
A. Scelfo, D. Fachinetti
semanticscholar   +1 more source