Results 61 to 70 of about 87,751 (339)

SEQUENCE OF CENTROMERE SEPARATION: ROLE OF CENTROMERIC HETEROCHROMATIN [PDF]

Genetics, 1982
ABSTRACT The late metaphase-early anaphase cells from various tissues of male Mus musculus, M. poschiavinus, M. spretus, M. castaneus, female and male Bos taurus (cattle) and female Myopus schisticolor (wood lemming) were analyzed for centromeres that showed separation into two daughter centromeres and those that did not show such ...
openaire   +2 more sources

Centromere-localized Aurora B kinase is required for the fidelity of chromosome segregation

Journal of Cell Biology, 2019
Aurora B localizes to centromeres, but it is unclear if this influences chromosome segregation in mitosis. Liang et al. find that two phospho-histone marks separately recruit Aurora B to centromeres and act redundantly for faithful chromosome segregation.
Cai Liang, Zhenlei Zhang, Qinfu Chen, Haiyan Yan, Miao Zhang, Linli Zhou, Junfen Xu, Weiguo Lu, Fangwei Wang   +8 more
semanticscholar   +1 more source

Mycophenolate Mofetil Treatment Reduces the Risk of Treatment Escalation Due to Vascular Complications in Limited Cutaneous Systemic Sclerosis: Emulation of a Target Trial From the Italian Rheumatology Society SPRING Registry

Arthritis Care &Research, EarlyView.
Objective Mycophenolate mofetil (MMF) use in limited cutaneous systemic sclerosis (lcSSc) is relatively uncommon because of the lower fibrotic burden and the predominance of vascular complications. In vitro observations and clinical data from transplanted patients suggest a protective effect of MMF on endothelial function.
Enrico De Lorenzis, Gerlando Natalello, Rossella De Angelis, Lucrezia Verardi, Dilia Giuggioli, Gianluigi Bajocchi, Lorenzo Dagna, Silvia Bellando‐Randone, Giovanni Zanframundo, Rosario Foti, Fabio Cacciapaglia, Giovanna Cuomo, Alarico Ariani, Edoardo Rosato, Gemma Lepri, Francesco Girelli, Valeria Riccieri, Elisabetta Zanatta, Ilaria Cavazzana, Francesca Ingegnoli, Maria De Santis, Giuseppe Murdaca, Giuseppina Abignano, Giorgio Pettiti, Alessandra Della Rossa, Maurizio Caminiti, Annamaria Iuliano, Giovanni Ciano, Lorenzo Beretta, Gianluca Bagnato, Ennio Lubrano, Maria Ilenia De Andres, Alessandro Giollo, Cosimo Bruni, Martina Orlandi, Marco Fornaro, Marta Saracco, Cecilia Agnes, Pier Giacomo Cerasuolo, Gabriella Alonzi, Edoardo Cipolletta, Federica Lumetti, Amelia Spinella, Luca Magnani, Corrado Campochiaro, Giacomo De Luca, Veronica Codullo, Elisa Visalli, Carlo Iandoli, Antonietta Gigante, Greta Pellegrino, Erika Pigatto, Maria‐Grazia Lazzaroni, Franco Franceschini, Elena Generali, Gianna Mennillo, Simone Barsotti, Giuseppa Pagano Mariano, Federica Furini, Licia Vultaggio, Simone Parisi, Clara Lisa Peroni, Gerolamo Bianchi, Enrico Fusaro, Gian Domenico Sebastiani, Marcello Govoni, Salvatore D'Angelo, Franco Cozzi, Fabrizio Conti, Serena Guiducci, Andrea Doria, Carlo Salvarani, Florenzo Iannone, Maria Antonietta D'Agostino, Clodoveo Ferri, Marco Matucci Cerinic, Silvia Laura Bosello, on behalf of the SPRING Italian Registry Collaborators   +77 more
wiley   +1 more source

Holocentric Chromosomes Probably Do Not Prevent Centromere Drive in Cyperaceae

Frontiers in Plant Science, 2021
Centromere drive model describes an evolutionary process initiated by centromeric repeats expansion, which leads to the recruitment of excess kinetochore proteins and consequent preferential segregation of an expanded centromere to the egg during female ...
Marie Krátká, Jakub Šmerda, Kateřina Lojdová, Petr Bureš, František Zedek   +4 more
doaj   +1 more source

Step-wise assembly, maturation and dynamic behavior of the human CENP-P/O/R/Q/U kinetochore sub-complex [PDF]

, 2012
Kinetochores are multi-protein megadalton assemblies that are required for attachment of microtubules to centromeres and, in turn, the segregation of chromosomes in mitosis. Kinetochore assembly is a cell cycle regulated multi-step process.
Tobias Ulbricht, Deng, Wen, Hellwig Daniela, Hofmeister, Antje, Hellwig, Daniela, Ulbricht Tobias, Döring, Volker, Leonhardt, Heinrich, McAinsh, Andrew D., Wen Deng, Eskat, Anja, James M Bancroft, Emmerth Stephan, Bancroft, James M, Diekmann, Stephan, Bancroft, James M., Volker Döring, Döring Volker, Bancroft James M., Cardoso, M. Cristina, Anja Eskat, Leonhardt Heinrich, Antje Hofmeister, Stephan Emmerth, Christian Hoischen, Rudolphi, Sven, Emmerth, Stephan, Hoischen, Christian, Stephan Diekmann, Rudolphi Sven, Cardoso, M Cristina, Eskat Anja, Heinrich Leonhardt, Hoischen Christian, Sven Rudolphi, Cardoso M. Cristina, Diekmann Stephan, Deng Wen, M Cristina Cardoso, Ulbricht, Tobias, Hofmeister Antje, Meraldi Patrick, McAinsh, Andrew D, Patrick Meraldi, McAinsh Andrew D., Meraldi, Patrick, Daniela Hellwig, Andrew D McAinsh   +47 more
core   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Structure and evolution of metapolycentromeres

Вавиловский журнал генетики и селекции
Metapolycentromeres consist of multiple sequential domains of centromeric chromatin associated with a centromere-specific variant of histone H3 (CENP-A), functioning collectively as a single centromere.
E. O. Grishko, P. M. Borodin
doaj   +1 more source

Transgenerational inheritance of centromere identity requires the CENP-A N-terminal tail in the C. elegans maternal germ line.

PLoS Biology, 2021
Centromere protein A (CENP-A) is a histone H3 variant that defines centromeric chromatin and is essential for centromere function. In most eukaryotes, CENP-A-containing chromatin is epigenetically maintained, and centromere identity is inherited from one
Reinier F Prosée, Joanna M Wenda, Isa Özdemir, Caroline Gabus, Kamila Delaney, Francoise Schwager, Monica Gotta, Florian A Steiner   +7 more
doaj   +1 more source

Centromere repositioning causes inversion of meiosis and generates a reproductive barrier

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Mutations in inner kinetochore components induce centromere repositioning without alteration in the centromeric DNA sequence, revealing a feedback mechanism underlying the high epigenetic stability of the centromere.
Min Lu, Xiangwei He
semanticscholar   +1 more source

Mitotic centromere-associated kinesin (MCAK) : a potential cancer drug target

, 2011
The inability to faithfully segregate chromosomes in mitosis results in chromosome instability, a hallmark of solid tumors. Disruption of microtubule dynamics contributes highly to mitotic chromosome instability.
Yuan, Juping, Louwen, Frank, Sanhaji, Mourad, Friel, Claire T., Wordeman, Linda   +4 more
core   +1 more source