Results 61 to 70 of about 92,899 (342)
Cell Reports, 2018 Summary: The centromere binding factor 3 (CBF3) complex binds the third centromere DNA element in organisms with point centromeres, such as S. cerevisiae.
Wenjuan Zhang +4 more
doaj +1 more source
Centromere scission drives chromosome shuffling and reproductive isolation
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The centromere is an essential chromosomal element that enables faithful segregation of chromosomes during cell division. In many species, centromeres are enriched in transposons and repetitive elements, and centromeres have been proposed to
V. Yadav +3 more
semanticscholar +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
RB dependent transcriptional regulation at mitotic centromeres preserves genome stability
Life Science AllianceLoss of the RB tumor suppressor drives centromere transcription, resulting in DNA damage and whole chromosome segregation errors. Transcripts derived from centromere repeats play a critical role in the localization and activity of kinetochore components ...
Elizabeth A Crowley, Amity L Manning
doaj +1 more source
Epigenetics & Chromatin, 2018 Background The centromere is the specialized chromatin region that directs chromosome segregation. The kinetochore assembles on the centromere, attaching chromosomes to microtubules in mitosis.
Jing Zhu +2 more
doaj +1 more source
Centromere plasmid: a new genetic tool for the study of Plasmodium falciparum. [PDF]
PLoS ONE, 2012 The introduction of transgenes into Plasmodium falciparum, a highly virulent human malaria parasite, has been conducted either by single crossover recombination or by using episomal plasmids.
Shiroh Iwanaga +3 more
doaj +1 more source
RNAi is a critical determinant of centromere evolution in closely related fungi
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance The “centromere paradox” refers to rapidly evolving and highly diverse centromere DNA sequences even in closely related eukaryotes. However, factors contributing to this rapid divergence are largely unknown.
V. Yadav +9 more
semanticscholar +1 more source
Chromosome ResearchCentromeres are fundamental chromosomal structures that ensure accurate chromosome segregation during cell division. Despite their conserved and essential role in maintaining genomic stability, centromeres are subject to rapid evolutionary change. At the heart of centromere identity is the histone H3 variant CENP-A, an epigenetic mark that defines and ...
Enriquez, Angela, Nechemia-Arbely, Yael
openaire +3 more sources
SEQUENCE OF CENTROMERE SEPARATION: ROLE OF CENTROMERIC HETEROCHROMATIN [PDF]
Genetics, 1982 ABSTRACT The late metaphase-early anaphase cells from various tissues of male Mus musculus, M. poschiavinus, M. spretus, M. castaneus, female and male Bos taurus (cattle) and female Myopus schisticolor (wood lemming) were analyzed for centromeres that showed separation into two daughter centromeres and those that did not show such ...
openaire +2 more sources
Discordance Between Patient and Physician Global Assessments in Early Systemic Sclerosis
Arthritis Care &Research, EarlyView.Objective This study aims to identify factors associated with patient global assessment (PtGA) and physician global assessment (PhGA) and discordance between them in systemic sclerosis (SSc). Methods Data from adults with early SSc (<5 years) from the Collaborative National Quality and Efficacy Registry were included.
Ellen Romich +35 more
wiley +1 more source