Results 81 to 90 of about 87,751 (339)
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
Advanced Science, EarlyView.PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu +12 more
wiley +1 more source
PLoS Genetics, 2019 Sister centromere fusion is a process unique to meiosis that promotes co-orientation of the sister kinetochores, ensuring they attach to microtubules from the same pole during metaphase I.
Lin-Ing Wang, Arunika Das, Kim S McKim
doaj +1 more source
Structure and Stability of Telocentric Chromosomes in Wheat. [PDF]
PLoS ONE, 2015 In most eukaryotes, centromeres assemble at a single location per chromosome. Naturally occurring telocentric chromosomes (telosomes) with a terminal centromere are rare but do exist.
Dal-Hoe Koo +3 more
doaj +1 more source
The Role of Human Centromeric RNA in Chromosome Stability
Frontiers in Molecular Biosciences, 2021 Chromosome instability is a hallmark of cancer and is caused by inaccurate segregation of chromosomes. One cellular structure used to avoid this fate is the kinetochore, which binds to the centromere on the chromosome.
Simon Leclerc, Katsumi Kitagawa
doaj +1 more source
Advanced Science, EarlyView.Oligonucleotide‐based fluorescence in situ hybridization probes were developed in the model citrus species Citrus maxima. These probes were applied to comparative karyotyping across 14 species in the Rutaceae family. This analysis revealed chromosomal evolution in lineages that diverged from Citrus nearly 52 million years ago.
Li He +9 more
wiley +1 more source
Centromere mechanical maturation during mammalian cell mitosis
Nature Communications, 2019 During mitosis, tension at the centromere occurs from the spindle but the role of centromere mechanics in controlling metaphase tension is poorly understood.
Lauren A. Harasymiw +4 more
doaj +1 more source
Cell Reports, 2013 The centromere of many eukaryotes contains highly repetitive sequences marked by methylation of histone H3K9 by Clr4KMT1. This recruits multiple heterochromatin proteins, including Swi6 and Chp1, to form a rigid centromere and ensure accurate chromosome ...
Pao-Chen Li +5 more
doaj +1 more source
The Ins and Outs of Aurora B Inner Centromere Localization
Front. Cell Dev. Biol., 2017 Error-free chromosome segregation is essential for the maintenance of genomic integrity during cell division. Aurora B, the enzymatic subunit of the Chromosomal Passenger Complex (CPC), plays a crucial role in this process.
Sanne Hindriksen, S. Lens, M. Hadders
semanticscholar +1 more source
Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine
Advanced Science, EarlyView.This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng +18 more
wiley +1 more source