Results 81 to 90 of about 92,899 (342)
Advanced Science, EarlyView.Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao +15 more
wiley +1 more source
Genes, 2018 Maintenance of an intact genome is essential for cellular and organismal homeostasis. The centromere is a specialized chromosomal locus required for faithful genome inheritance at each round of cell division.
E. M. Black, Simona Giunta
semanticscholar +1 more source
Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere [PDF]
, 2007 The centromere is a complex structure, the components and assembly pathway of which remain inadequately defined. Here, we demonstrate that centromeric alpha-satellite RNA and proteins CENPC1 and INCENP accumulate in the human interphase nucleolus in an ...
E. Williams +21 more
core +1 more source
Advanced Science, EarlyView.A living multi‐omics sarcoma PDX biobank is enriched for high‐risk disease and preserves key patient tumor features at histopathological and molecular levels. Integrated profiling reveals ecDNA‐driven oncogene amplification in osteosarcoma and preferential retention of ecDNA during PDX evolution.
Weisong Zhao +34 more
wiley +1 more source
Centromere repositioning causes inversion of meiosis and generates a reproductive barrier
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Mutations in inner kinetochore components induce centromere repositioning without alteration in the centromeric DNA sequence, revealing a feedback mechanism underlying the high epigenetic stability of the centromere.
Min Lu, Xiang-Wei He
semanticscholar +1 more source
Advanced Science, EarlyView.We present a complete T2T genome assembly for a key bat reservoir. Integrating population genomics, comparative genomics, transcriptomics, single‐cell omics, and functional assays, we resolve previously inaccessible genomic regions and identify evolutionary signatures associated with immune adaptation.
Yuting Wang +15 more
wiley +1 more source
Structure of centromere chromatin: from nucleosome to chromosomal architecture. [PDF]
, 2016 The centromere is essential for the segregation of chromosomes, as it serves as attachment site for microtubules to mediate chromosome segregation during mitosis and meiosis.
Florian A. Steiner (7735019) +1 more
core +4 more sources
Nature Cell Biology, 2016 Chromosome missegregation into a micronucleus can cause complex and localized genomic rearrangements known as chromothripsis, but the underlying mechanisms remain unresolved.
P. Ly +7 more
semanticscholar +1 more source
Centromere-linked LacO position in wildtype and anaphase cells.
, 2016 GAL-CEN3 proximal lacO arrays in metaphase (A) (n = 84 to 92 cells) and anaphase (B) (n = 34 to 51 cells) cells. Cells were grown on galactose for 3h prior to image analysis.
Benjamin Harrison (2634193) +8 more
core +1 more source
Genetic dissection of centromere function. [PDF]
, 1993 A system to detect a minimal function of Saccharomyces cerevisiae centromeres in vivo has been developed. Centromere DNA mutants have been examined and found to be active in a plasmid copy number control assay in the absence of segregation.
Schulman, I G +3 more
core +1 more source