Results 101 to 110 of about 87,751 (339)

Immune Complexes Shape the Pathogenicity of Autoantibodies in Systemic Autoimmune Diseases: Insights From an FcγRIIIA‐Reporter Assay

Arthritis &Rheumatology, EarlyView.
Objective Immune complexes (ICs), formed by autoantigen and autoantibody, play a pathogenic role in systemic autoimmune diseases through stimulation of Fcγ receptors (FcγR). However, studies investigating bioactivity of circulating ICs across various diseases remain limited.
Koji Suzuki, Masaru Takeshita, Yuki Imai, Hiroyuki Fukui, Kazunori Furuhashi, Kotaro Matsumoto, Jun Kikuchi, Keiko Yoshimoto, Yuko Kaneko   +8 more
wiley   +1 more source

Neocentromeres Provide Chromosome Segregation Accuracy and Centromere Clustering to Multiple Loci along a Candida albicans Chromosome. [PDF]

PLoS Genetics, 2016
Assembly of kinetochore complexes, involving greater than one hundred proteins, is essential for chromosome segregation and genome stability. Neocentromeres, or new centromeres, occur when kinetochores assemble de novo, at DNA loci not previously ...
Laura S Burrack, Hannah F Hutton, Kathleen J Matter, Shelly Applen Clancey, Ivan Liachko, Alexandra E Plemmons, Amrita Saha, Erica A Power, Breanna Turman, Mathuravani Aaditiyaa Thevandavakkam, Ferhat Ay, Maitreya J Dunham, Judith Berman   +12 more
doaj   +1 more source

α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere

Nature Communications, 2017
Centromeres are unique chromosomal domains that control chromosome segregation, and are epigenetically specified by the presence of the CENP-A containing nucleosomes. CENP-A governs centromere function by recruiting the constitutive centromere associated
K. Sathyan, D. Fachinetti, D. Foltz
semanticscholar   +1 more source

Expert Perspectives: Defining and managing progressive pulmonary fibrosis in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
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Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Anti-centromere antibody positivity with coexisting idiopathic portal hypertension and primary biliary cholangitis progressing to limited cutaneous systemic sclerosis: a case report

Journal of Medical Case Reports
Background Anti-centromere antibodies are autoantibodies that selectively bind to the centromere region of chromosomes. Studies have indicated that anti-centromere antibodies can induce microvascular alterations and tissue remodeling, ultimately leading ...
Yuya Ando, Suguru Mabuchi, Norikazu Mataki, Satoshi Nakayama, Arata Honda, Mari Kamiya, Shinsuke Yasuda, Hiroaki Takeo, Shigeaki Aono, Masayoshi Hashimoto, Kenichi Harada, Naoya Murashima   +11 more
doaj   +1 more source

A time out for CENP-A

Molecular & Cellular Oncology, 2017
Proper chromosome segregation relies on a functional centromere–kinetochore interface. We showed that chromatin containing CENtromere Protein A (CENP-A) is essential for centromere assembly, but dispensable for chromosome segregation in the presence of ...
S. Hoffmann, D. Fachinetti
doaj   +1 more source

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Centromere deletion in Cryptococcus deuterogattii leads to neocentromere formation and chromosome fusions

eLife, 2020
The human fungal pathogen Cryptococcus deuterogattii is RNAi-deficient and lacks active transposons in its genome. C. deuterogattii has regional centromeres that contain only transposon relics.
Klaas Schotanus, Joseph Heitman
doaj   +1 more source

Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I

Nature Communications, 2017
A key feature of meiosis is the step-wise removal of cohesin, the protein complex holding sister chromatids together, first from arms in meiosis I and then from the centromere region in meiosis II.
Warif El Yakoubi, Eulalie Buffin, Damien Cladière, Yulia Gryaznova, Ines Berenguer, Sandra A. Touati, R. Gómez, J. Suja, J. V. van Deursen, Katja Wassmann   +9 more
semanticscholar   +1 more source

Determining the Mechanisms of De Novo Centromere Formation in C. elegans Embryos

, 2014
The centromere is the single, specialized chromosomal domain responsible for directing chromosome segregation. Maintaining one centromere per chromosome ensures chromosome stability. However, new centromeres can form at ectopic, non-centromeric locations
Lee, CH, Cheng, CLK, Yuen, KWY, Lin, Z
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