Results 121 to 130 of about 87,751 (339)

Stable centromere positioning in diverse sequence contexts of complex and satellite centromeres of maize and wild relatives

Genome Biology, 2017
Paradoxically, centromeres are known both for their characteristic repeat sequences (satellite DNA) and for being epigenetically defined. Maize (Zea mays mays) is an attractive model for studying centromere positioning because many of its large (~2 Mb ...
J. Gent, Na Wang, R. Dawe
semanticscholar   +1 more source

Centromere-stabilized aneuploid states leads to antifungal drug resistance.

(a) A table summarizing the outcome of karyotype alterations induced by different antifungal drugs in various pathogenic fungi. (b) Stable aneuploid states existing as whole chromosomes or supernumerary chromosomes arising from the core chromosomes.
Kaustuv Sanyal (169834), Md. Hashim Reza (18271476), Aswathy Narayanan (9903642)   +2 more
core   +1 more source

Silencing SGO2 by Oxamic Acid Dissociates Glycolysis and BRCA1‐Mediated DNA Repair to Improve the Chemosensitivity of Lung Adenocarcinoma

Exploration, EarlyView.
SGO2 interacts with BRCA1 to inhibit BRCA1 ubiquitination and degradation, thereby promoting BRCA1‐induced DNA damage repair signaling and reducing the chemo sensitivity of LUADa. OA targets glycolysis to disrupt H3K18la‐ and H3K27ac‐mediated chromatin accessibility, repressing SGO2 transcription and subsequently alleviating SGO2‐mediated cancer ...
Xian Lin, Zhidan Hua, Chen Liu, Minxia Yang, Beilei Zhang, Xiaofeng Zhu, Xiao Chen   +6 more
wiley   +1 more source

α satellite DNA variation and function of the human centromere

The Nucleus, 2017
Genomic variation is a source of functional diversity that is typically studied in genic and non-coding regulatory regions. However, the extent of variation within noncoding portions of the human genome, particularly highly repetitive regions, and the ...
Lori L. Sullivan, Kimberline Chew, B. Sullivan   +2 more
semanticscholar   +1 more source

Determining the function of histone modifications and transcription during centromere establishment in Caenorhabditis elegans

, 2018
The centromere is a chromosomal region specialized for directing chromosome segregation. The kinetochore assembles on the centromere, attaching microtubules to chromosomes in mitosis.
Zhu, J, Yuen, KWY
core  

Lymphocyte Micronucleus Formation Is Driven by Inflammation‐Induced Oxidative DNA Damage in Oesophageal Cancer Development

International Journal of Cancer, EarlyView.
Chromosomal instability is a hallmark of cancer, but minimally invasive ways to detect systemic DNA damage and cancer risk remain limited. Here, using patient blood samples, the authors investigated lymphocyte micronuclei (MN) frequency as a potential marker of DNA damage across the progression from gastroesophageal reflux disease to Barrett's ...
Kathryn Munn, Rachel Lawrence, Hasan Haboubi, Hamsa Naser, Kate Hurlow, Ume‐Kulsoom Shah, Lisa Williams, Sarah Gwynne, Owen Bodger, Jiri Zavadil, Francois Virard, Shareen Doak, Laura E. Thomas, Gareth Jenkins   +13 more
wiley   +1 more source

Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

Nature Communications, 2016
Chromosomal instability (CIN) is a hallmark of cancer that contributes to tumour heterogeneity and other malignant properties. Aberrant centromere and kinetochore function causes CIN through chromosome missegregation, leading to aneuploidy ...
Weiguo Zhang, J. Mao, Wei Zhu, A. Jain, K. Liu, James B. Brown, G. Karpen   +6 more
semanticscholar   +1 more source

Impact of Methylparaben on Cumulus Cell DNA Integrity and Porcine Oocyte Developmental Competence In Vitro

Journal of Applied Toxicology, EarlyView.
ABSTRACT Parabens (PBs) are compounds widely used as preservatives in personal care products, food, and pharmaceuticals. Methylparaben (MePB) is the most used by different industries due to its chemical properties and low cost. The high daily human exposure to these compounds has raised concerns about their potential effects on health, particularly on ...
Yenny Ramírez‐Jara, Brenda Casado, Miguel Betancourt, Adyeni Barajas‐Salinas, Eduardo Casas, Gabriela Hurtado‐Alvarado, Juan José Rodríguez‐Mercado, Alma López, Iván Bahena, Lizbeth Juárez‐Rojas, Leticia González‐Núñez, Fahiel Casillas   +11 more
wiley   +1 more source

PBRM1 directs PBAF to pericentromeres and protects centromere integrity

Nature Communications
The specialised structure of the centromere is critical for effective chromosome segregation, but its repetitive nature makes it vulnerable to rearrangements.
Karen A. Lane, Alison Harrod, Lillian Wu, Theodoros I. Roumeliotis, Hugang Feng, Shane Foo, Katheryn A. G. Begg, Federica Schiavoni, Noa Amin, Frank T. Zenke, Alan A. Melcher, Jyoti S. Choudhary, Jessica A. Downs   +12 more
doaj   +1 more source

Centromeres [PDF]

Current Biology, 2001
Allshire, Robin, Pidoux, Alison
openaire   +2 more sources