Results 121 to 130 of about 92,899 (342)
α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere
Nature Communications, 2017 Centromeres are unique chromosomal domains that control chromosome segregation, and are epigenetically specified by the presence of the CENP-A containing nucleosomes. CENP-A governs centromere function by recruiting the constitutive centromere associated
K. Sathyan, D. Fachinetti, D. Foltz
semanticscholar +1 more source
Determining the cellular mechanism of de novo centromere establishment in C. elegans embryos
, 2016 De novo centromere formed rapidly on artificial chromosomes (ACs) after injecting DNA in C. elegans germline. The mechanisms underlining nucleation of a de novo centromere from naked DNA is not known.
Yuen, KWY, Lin, Z
core
PROTEOMICS, EarlyView.ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca +7 more
wiley +1 more source
CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions
Cell Reports, 2016 The presence of chromatin containing the histone H3 variant CENP-A dictates the location of the centromere in a DNA sequence-independent manner. But the mechanism by which centromere inheritance occurs is largely unknown. We previously reported that CENP-
Yohei Niikura +2 more
doaj +1 more source
eLife, 2020 The human fungal pathogen Cryptococcus deuterogattii is RNAi-deficient and lacks active transposons in its genome. C. deuterogattii has regional centromeres that contain only transposon relics.
Klaas Schotanus, Joseph Heitman
doaj +1 more source
Nature Communications, 2017 A key feature of meiosis is the step-wise removal of cohesin, the protein complex holding sister chromatids together, first from arms in meiosis I and then from the centromere region in meiosis II.
W. El Yakoubi +9 more
semanticscholar +1 more source
Determining the Mechanisms of De Novo Centromere Formation in C. elegans Embryos
, 2014 The centromere is the single, specialized chromosomal domain responsible for directing chromosome segregation. Maintaining one centromere per chromosome ensures chromosome stability. However, new centromeres can form at ectopic, non-centromeric locations
Lee, CH, Cheng, CLK, Yuen, KWY, Lin, Z
core
Russian wheat aphid: a model for genomic plasticity and a challenge to breeders
Insect Science, EarlyView.Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn +8 more
wiley +1 more source
Molecular & Cellular Oncology, 2017 Proper chromosome segregation relies on a functional centromere–kinetochore interface. We showed that chromatin containing CENtromere Protein A (CENP-A) is essential for centromere assembly, but dispensable for chromosome segregation in the presence of ...
S. Hoffmann, D. Fachinetti
doaj +1 more source
eLife, 2014 In budding yeast, a single cenH3 (Cse4) nucleosome occupies the ∼120-bp functional centromere, however conflicting structural models for the particle have been proposed. To resolve this controversy, we have applied H4S47C-anchored cleavage mapping, which
Steven Henikoff +8 more
doaj +1 more source