Results 111 to 120 of about 87,751 (339)
Centromere-associated molecular events contribute to species diversification in fungal pathogens.
(a–e) Various molecular events involving centromeres leading to species diversification are depicted, with examples found among the fungal pathogens. (f) An evolutionary model for chromosomal fusion and centromere inactivation in the Malassezia species ...
Kaustuv Sanyal (169834) +2 more
core +1 more source
Discovery of an Atypical Arp2/3 Complex in Malaria Parasites Sheds New Light on Nuclear Actin
Cytoskeleton, EarlyView.ABSTRACT The Arp2/3 complex is a key actin nucleator essential for cytoskeletal dynamics in eukaryotes. Previously believed absent in apicomplexan parasites, we recently identified an atypical Arp2/3 complex in malaria parasites consisting of five divergent subunits and a putative kinetochore‐associated factor.
Franziska Hentzschel +2 more
wiley +1 more source
CENP-A Ubiquitylation Is Inherited through Dimerization between Cell Divisions
Cell Reports, 2016 The presence of chromatin containing the histone H3 variant CENP-A dictates the location of the centromere in a DNA sequence-independent manner. But the mechanism by which centromere inheritance occurs is largely unknown. We previously reported that CENP-
Yohei Niikura +2 more
doaj +1 more source
Centromere location in Arabidopsis is unaltered by extreme divergence in CENH3 protein sequence
Genome Research, 2017 During cell division, spindle fibers attach to chromosomes at centromeres. The DNA sequence at regional centromeres is fast evolving with no conserved genetic signature for centromere identity.
S. Maheshwari +4 more
semanticscholar +1 more source
Determining the cellular mechanism of de novo centromere establishment in C. elegans embryos
, 2016 De novo centromere formed rapidly on artificial chromosomes (ACs) after injecting DNA in C. elegans germline. The mechanisms underlining nucleation of a de novo centromere from naked DNA is not known.
Yuen, KWY, Lin, Z
core
Cytoskeleton, EarlyView.ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos +5 more
wiley +1 more source
eLife, 2014 In budding yeast, a single cenH3 (Cse4) nucleosome occupies the ∼120-bp functional centromere, however conflicting structural models for the particle have been proposed. To resolve this controversy, we have applied H4S47C-anchored cleavage mapping, which
Steven Henikoff +8 more
doaj +1 more source
Centromere evolution and CpG methylation during vertebrate speciation
Nature Communications, 2017 Centromeres and large-scale structural variants evolve and contribute to genome diversity during vertebrate speciation. Here, we perform de novo long-read genome assembly of three inbred medaka strains that are derived from geographically isolated ...
Kazuki Ichikawa +11 more
semanticscholar +1 more source
Epigenetic regulation of centromere function
, 2020 The centromere is a specialized region on the chromosome that directs equal chromosome segregation. Centromeres are usually not defined by DNA sequences alone.
Lee, BCH, Wong, CYY, Yuen, KWY
core +1 more source
Epilepsia, EarlyView.Abstract Objective Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is an underrecognized pediatric cortical lesion associated with somatic X‐linked SLC35A2 variants in approximately 50% of individuals. The genetic etiology in individuals without detectable SLC35A2 mutations remains undefined, which limits
Erica Cecchini +13 more
wiley +1 more source