Results 111 to 120 of about 92,899 (342)

Centromere variation and de novo centromere formation in wheat aneuploids and derivatives of wheat wild hybrids.

, 2016
Centromere variation and de novo centromere formation in wheat aneuploids and derivatives of wheat wild hybrids.
Qinghua Shi (169845), Zanmin Hu (115973), Fangpu Han (257046), Shulan Fu (289000), Xiangqi Zhang (193837), Handong Su (2626918), Xiang Guo (223678), Jing Wang (1228470)   +7 more
core   +1 more source

Sorghum T2T pangenome highlights comprehensive genomic variation

iMetaOmics, EarlyView.
Three newly assembled telomere‐to‐telomere (T2T) genomes representing wild, landrace, and transformable germplasm were integrated with seven publicly available T2T genomes to construct a graph‐based pangenome. Comparative analyses revealed extensive centromere divergence, including distinct CEN137 monomer and CEN274 dimer organization, and showed that ...
Lihua Wang, Chuanzheng Wei, Hope O. Okunbor, Xiaofei Deng, Die Hu, Yongfei Wang, Junli Du, Ephrem Habyarimana, Yongfu Tao, Yi‐Hong Wang, Jieqin Li   +10 more
wiley   +1 more source

Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing

Nature Communications, 2017
Faithful chromosome segregation during mitosis requires that the kinetochores of all sister chromatids become stably connected to microtubules derived from opposite spindle poles.
R. Hengeveld, Martijn J. M. Vromans, Mathijs Vleugel, M. A. Hadders, S. Lens   +4 more
semanticscholar   +1 more source

Nephrogenic Systemic Fibrosis: A Rare Contemporary Case After a Decade of Declining Incidence

JEADV Clinical Practice, EarlyView.
ABSTRACT Nephrogenic systemic fibrosis (NSF) is a rare fibrosing disorder associated with exposure to gadolinium‐based contrast agents in patients with renal impairment. Although its incidence has markedly declined since the restriction of high‐risk linear gadolinium agents, sporadic cases may still occur.
Marta Sánchez Díaz, Alberto Andamoyo Castañeda, Pedro José Navarro Guillamón, Elena Gallego Domínguez, Jorge Alonso Suárez Pérez, Enrique Herrera Acosta   +5 more
wiley   +1 more source

Centromere Biology: Transcription Goes on Stage

Molecular and Cellular Biology, 2018
Accurate chromosome segregation is a fundamental process in cell biology. During mitosis, chromosomes are segregated into daughter cells through interactions between centromeres and microtubules in the mitotic spindle.
C. Perea-Resa, Michael D. Blower
semanticscholar   +1 more source

Image_1_Only the Rye Derived Part of the 1BL/1RS Hybrid Centromere Incorporates CENH3 of Wheat.TIF

, 2021
The precise assembly of the kinetochore complex at the centromere is epigenetically determined by substituting histone H3 with the centromere-specific histone H3 variant CENH3 in centromeric nucleosomes.
Veit Schubert (254739), Andreas Houben (527617), Raheleh Karimi-Ashtiyani (11828615)   +2 more
core   +1 more source

Anti-centromere antibody positivity with coexisting idiopathic portal hypertension and primary biliary cholangitis progressing to limited cutaneous systemic sclerosis: a case report

Journal of Medical Case Reports
Background Anti-centromere antibodies are autoantibodies that selectively bind to the centromere region of chromosomes. Studies have indicated that anti-centromere antibodies can induce microvascular alterations and tissue remodeling, ultimately leading ...
Yuya Ando, Suguru Mabuchi, Norikazu Mataki, Satoshi Nakayama, Arata Honda, Mari Kamiya, Shinsuke Yasuda, Hiroaki Takeo, Shigeaki Aono, Masayoshi Hashimoto, Kenichi Harada, Naoya Murashima   +11 more
doaj   +1 more source

Resolving Complex Structural Variants in Undiagnosed Rare Movement Disorders via Multimodal Genomics and Multi‐omics

Movement Disorders, EarlyView.
Abstract Background Long‐read sequencing and multi‐omic analytical frameworks are increasingly being adopted in rare disease diagnostics. However, clinical workflows comprehensively integrating these methodologies remain uncommon. Objective This study aimed to assess the potential and limitations of integrating long‐read genomic, transcriptomic, and ...
Ugo Sorrentino, Melanie Brugger, Alice Saparov, Ivana Dzinovic, Philip Harrer, Sandy Lösecke, Kevork Derderian, Martin Pavlov, Robert Kopajtich, Holger Prokisch, Arcangela Iuso, Maria Mazurkiewicz‐Bełdzińska, Deike Weiss, Christina Ludwig, Miriam Abele, Julia Mergner, Juliane Winkelmann, Theresa Brunet, Michał Schinwelski, Elisabeth Graf, Katja Kloth‐Stachnau, Theresia Herget, Magdalena Krygier, Michael Zech   +23 more
wiley   +1 more source

Centromere-stabilized aneuploid states leads to antifungal drug resistance.

(a) A table summarizing the outcome of karyotype alterations induced by different antifungal drugs in various pathogenic fungi. (b) Stable aneuploid states existing as whole chromosomes or supernumerary chromosomes arising from the core chromosomes.
Kaustuv Sanyal (169834), Md. Hashim Reza (18271476), Aswathy Narayanan (9903642)   +2 more
core   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source