The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast. [PDF]
PLoS Genetics, 2014 Heterochromatin preferentially assembles at repetitive DNA elements, playing roles in transcriptional silencing, recombination suppression, and chromosome segregation.
Scott P Kallgren +8 more
doaj +1 more source
Constitutive Heterochromatin in Eukaryotic Genomes: A Mine of Transposable Elements
Cells, 2022 Transposable elements (TEs) are abundant components of constitutive heterochromatin of the most diverse evolutionarily distant organisms. TEs enrichment in constitutive heterochromatin was originally described in the model organism Drosophila ...
René Massimiliano Marsano +1 more
doaj +1 more source
Maternal depletion of Piwi, a component of the RNAi system, impacts heterochromatin formation in Drosophila. [PDF]
PLoS Genetics, 2013 A persistent question in epigenetics is how heterochromatin is targeted for assembly at specific domains, and how that chromatin state is faithfully transmitted.
Tingting Gu, Sarah C R Elgin
doaj +1 more source
DNA Double-Strand Break Repair: All Roads Lead to HeterochROMAtin Marks
Frontiers in Genetics, 2021 In response to DNA double-strand breaks (DSBs), chromatin modifications orchestrate DNA repair pathways thus safeguarding genome integrity. Recent studies have uncovered a key role for heterochromatin marks and associated factors in shaping DSB repair ...
Pierre Caron +2 more
doaj +1 more source
53BP1 regulates heterochromatin through liquid phase separation
Nature Communications, 2022 Human 53BP1 is primarily known as a key player in regulating DNA double strand break (DSB) repair choice; however, its involvement in other biological process is less well understood.
Lei Zhang +18 more
semanticscholar +1 more source
Rapid epigenetic adaptation to uncontrolled heterochromatin spreading
eLife, 2015 Heterochromatin, a highly compact chromatin state characterized by histone H3K9 methylation and HP1 protein binding, silences the underlying DNA and influences the expression of neighboring genes.
Jiyong Wang, Bharat D Reddy, Songtao Jia
doaj +1 more source
The highly dynamic heterochromatin protein Swi6 mediates degradation of heterochromatic transcripts [PDF]
, 2014 The aim of my thesis was to investigate the mechanism of heterochromatin repression mediated by heterochromatin protein Swi6 in S. pombe. Research over the years challenged the view of heterochromatin as a static and transcriptionally inert structure ...
Stunnenberg, Rieka
core +1 more source
Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex
Epigenetics & Chromatin, 2021 Splicing factors have recently been shown to be involved in heterochromatin formation, but their role in controlling heterochromatin structure and function remains poorly understood.
Martina Weigt +7 more
doaj +1 more source
SIRT3 consolidates heterochromatin and counteracts senescence
Nucleic Acids Research, 2021 Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of physiological and pathological processes, including aging and aging-related diseases. However, the role of SIRT3 in regulating human stem cell homeostasis remains unclear. Here
Zhiqing Diao +15 more
semanticscholar +1 more source
Transcriptional gene silencing mutants in "Arabidopsis thaliana" and their impact on nuclear architecture and heterochromatin organization [PDF]
, 2004 The epigenetic regulation of gene expression is defined by covalent modifications of DNA and histone tails as well as by chromatin structure and nuclear architecture.
Valeska Probst, Aline
core +1 more source