Results 21 to 30 of about 81,802 (259)

Functional crosstalk between mTORC1/p70S6K pathway and heterochromatin organization in stress-induced senescence of MSCs

Stem Cell Research & Therapy, 2020
Background Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases. Activation of mTORC1 pathway and heterochromatin organization have been characterized as two characteristics
Hailong Liu, Biao Huang, Shaolong Xue, Kin Pong U, Lai Ling Tsang, Xiaohu Zhang, Gang Li, Xiaohua Jiang   +7 more
doaj   +1 more source

PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina

Nucleus, 2023
The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva, Yu-Chia Cheng, Cheryl L. Smith, Richard A. Katz, Andrey Poleshko   +4 more
doaj   +1 more source

Spt5 C-terminal repeat domain phosphorylation and length negatively regulate heterochromatin through distinct mechanisms.

PLoS Genetics, 2023
Heterochromatin is a condensed chromatin structure that represses transcription of repetitive DNA elements and developmental genes, and is required for genome stability.
Sarah MacKinnon, Viviane Pagé, Jennifer J Chen, Ali Shariat-Panahi, Ryan D Martin, Terence E Hébert, Jason C Tanny   +6 more
doaj   +1 more source

Regulation of heterochromatic RNA decay via heterochromatin protein 1 (HP1) [PDF]

, 2012
The central dogma of molecular biology describes the directional flow of biological information from DNA via RNA to protein. Information stored in DNA is copied to an mRNA molecule during the process of transcription.
Keller, Claudia Isabelle
core   +1 more source

Negative Regulators of an RNAi-Heterochromatin Positive Feedback Loop Safeguard Somatic Genome Integrity in Tetrahymena

Cell Reports, 2017
RNAi-mediated positive feedback loops are pivotal for the maintenance of heterochromatin, but how they are downregulated at heterochromatin-euchromatin borders is not well understood.
Jan H. Suhren, Tomoko Noto, Kensuke Kataoka, Shan Gao, Yifan Liu, Kazufumi Mochizuki   +5 more
doaj   +1 more source

Candida albicans repetitive elements display epigenetic diversity and plasticity [PDF]

, 2016
Transcriptionally silent heterochromatin is associated with repetitive DNA. It is poorly understood whether and how heterochromatin differs between different organisms and whether its structure can be remodelled in response to environmental signals. Here,
Freire-Benéitez, Veronica, Tarrant, Daniel, Buscaino, Alessia, Berman, Judith, Price, Robert Jordan   +4 more
core   +1 more source

Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation

Cell Reports, 2020
Summary: Heterochromatin functions as a scaffold for factors responsible for gene silencing and chromosome segregation. Heterochromatin can be assembled by multiple pathways, including RNAi and RNA surveillance.
Si Young Lee, Stevephen Hung, Caroline Esnault, Rakesh Pathak, Kory R. Johnson, Oluwadamilola Bankole, Akira Yamashita, Hongen Zhang, Henry L. Levin   +8 more
doaj   +1 more source

Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. [PDF]

PLoS Genetics, 2012
Organismal aging is influenced by a multitude of intrinsic and extrinsic factors, and heterochromatin loss has been proposed to be one of the causes of aging. However, the role of heterochromatin in animal aging has been controversial.
Kimberly Larson, Shian-Jang Yan, Amy Tsurumi, Jacqueline Liu, Jun Zhou, Kriti Gaur, Dongdong Guo, Thomas H Eickbush, Willis X Li   +8 more
doaj   +1 more source

The RNA Polymerase II-associated factor 1 complex represses small-RNA-mediated heterochromatin formation and gene silencing [PDF]

, 2015
RNAi interference (RNAi) is a highly conserved regulatory mechanism employed by almost all Eukaryotes. With RNAi organisms can modulate the expression of endogenous genes and protect the integrity and identity of their genomes.
Kowalik, Katarzyna Maria
core   +1 more source

Heterochromatin-dependent transcription of satellite DNAs in the Drosophila female germline

, 2020
Presentation of poster 631A at TAGC 2020 Online. Files include a PDF of the poster (Heterochromatin-dependent transcription of satellite DNAs in the Drosophila female germline.pdf)
Xiaolu Wei (8726532), Amanda M Larracuente (5960984), Danna G. Eickbush (8726537), Iain Speece (8726538)   +3 more
core   +1 more source