Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome
Genome Medicine, 2020 Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant
Florian Köhler +9 more
doaj +1 more source
Dual Left Anterior Descending Artery: Clinical Overview and Interventional Management
Journal of Tehran University Heart Center, 2023 Congenital coronary artery anomalies are relatively rare, occurring in approximately 0.6%-1.3% of cases undergoing coronary angiography. Among these anomalies, a unique cardiac abnormality known as a dual left anterior descending artery (LAD) stands out.
Shahab Masoumi +4 more
doaj +1 more source
Role of lamins in 3D genome organization and global gene expression
Nucleus, 2019 Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
doaj +1 more source
Association of Lamina-Associated Domains (LADs) with ToR.
, 2012 LADs association in 3 different mouse tissues was calculated for each probe. Pearson correlation values (R) are shown between the ToR and LADs for each tissue.
Zohar Yakhini (14865) +7 more
core +1 more source
The insulator protein SU(HW) fine-tunes nuclear lamina interactions of the Drosophila genome.
PLoS ONE, 2010 Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression.
Joke G van Bemmel +6 more
doaj +1 more source
CTCF and cohesin promote focal detachment of DNA from the nuclear lamina
Genome Biology, 2022 Background Lamina-associated domains (LADs) are large genomic regions that are positioned at the nuclear lamina. It has remained largely unclear what drives the positioning and demarcation of LADs.
Tom van Schaik +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz +6 more
wiley +1 more source
Guide for officers, warrant officers, non-commissioned officers, and privates of the Church Lads' Brigade : and Church Lads' Brigade infantry training [PDF]
, 1910 Church Lads' Brigade Guide for Officers, Warrant Officers ...
Church Lads' Brigade (London, England)
core
Lamin C is required to establish genome organization after mitosis
Genome Biology, 2021 Background The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the nuclear periphery.
Xianrong Wong +5 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source