Restructuring of Lamina-Associated Domains in Senescence and Cancer [PDF]
Cells, 2022 Induction of cellular senescence or cancer is associated with a reshaping of the nuclear envelope and a broad reorganization of heterochromatin. At the periphery of mammalian nuclei, heterochromatin is stabilized at the nuclear lamina via lamina ...
Aurélie Bellanger +3 more
doaj +4 more sources
Mapping the micro-proteome of the nuclear lamina and lamina-associated domains [PDF]
Life Science Alliance, 2021 The nuclear lamina provides structure to the nucleus and serves as an interface between the cytoskeleton and large heterochromatin domains called LADs. This study describes the microproteome of this LAD/lamina interface.
Xianrong Wong +6 more
doaj +4 more sources
Chromatin protein complexes involved in gene repression in lamina-associated domains [PDF]
The EMBO JournalLamina-associated domains (LADs) are large chromatin regions that are associated with the nuclear lamina (NL) and form a repressive environment for transcription. The molecular players that mediate gene repression in LADs are currently unknown.
Stefano G Manzo +8 more
doaj +3 more sources
Lamina-associated domains: peripheral matters and internal affairs [PDF]
Genome Biology, 2020 At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-associated domains (LADs) aid functional organization of the genome.
Nolwenn Briand, Philippe Collas
doaj +4 more sources
Lamina Associated Domains and Gene Regulation in Development and Cancer [PDF]
Cells, 2019 The nuclear lamina (NL) is a thin meshwork of filaments that lines the inner nuclear membrane, thereby providing a platform for chromatin binding and supporting genome organization.
Silke J. A. Lochs +2 more
doaj +4 more sources
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome [PDF]
Genome Medicine, 2020 Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant
Florian Köhler +9 more
doaj +2 more sources
Local euchromatin enrichment in lamina-associated domains anticipates their repositioning in the adipogenic lineage [PDF]
Genome Biology, 2022 Background Interactions of chromatin with the nuclear lamina via lamina-associated domains (LADs) confer structural stability to the genome. The dynamics of positioning of LADs during differentiation, and how LADs impinge on developmental gene expression,
Julia Madsen-Østerbye +3 more
doaj +2 more sources
Transcription-independent TFIIIC-bound sites cluster near heterochromatin boundaries within lamina-associated domains in C. elegans [PDF]
Epigenetics & Chromatin, 2020 Background Chromatin organization is central to precise control of gene expression. In various eukaryotic species, domains of pervasive cis-chromatin interactions demarcate functional domains of the genomes.
Alexis V. Stutzman +3 more
doaj +2 more sources
Strong interactions between highly dynamic lamina-associated domains and the nuclear envelope stabilize the 3D architecture of Drosophila interphase chromatin [PDF]
Epigenetics & Chromatin, 2023 Background Interactions among topologically associating domains (TADs), and between the nuclear envelope (NE) and lamina-associated domains (LADs) are expected to shape various aspects of three-dimensional (3D) chromatin structure and dynamics; however ...
Igor S. Tolokh +3 more
doaj +2 more sources
Choreography of lamina‐associated domains: structure meets dynamics [PDF]
FEBS Letters, 2023 Karen Reddy
exaly +2 more sources