Results 11 to 20 of about 8,868,086 (239)

Gene Regulatory Interactions at Lamina-Associated Domains [PDF]

Genes, 2023
The nuclear lamina provides a repressive chromatin environment at the nuclear periphery. However, whereas most genes in lamina-associated domains (LADs) are inactive, over ten percent reside in local euchromatic contexts and are expressed. How these genes are regulated and whether they are able to interact with regulatory elements remain unclear. Here,
M Abdelhalim, Philippe Collas, Sarah Hazell Pickering   +2 more
exaly   +7 more sources

Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression [PDF]

Cell, 2017
In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression.
Bas van Steensel, Andrew Belmont
exaly   +7 more sources

Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity [PDF]

Genes and Development, 2023
Fertilization in mammals is accompanied by an intense period of chromatin remodeling and major changes in nuclear organization. How the earliest events in embryogenesis, including zygotic genome activation (ZGA) during maternal-to-zygotic transition, influence such remodeling remains unknown.
Maria-Elena Torres-Padilla, Mrinmoy Pal   +1 more
exaly   +5 more sources

Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease [PDF]

Genome Research, 2022
Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in type 2 diabetes mellitus and the elderly, impacting 40% of individuals over 70. Regulation of heterochromatin at the nuclear lamina has been associated with aging and age-dependent metabolic changes. We previously showed that changes at the lamina in aged hepatocytes and laminopathy models
Irina Bochkis, Jeffrey Saucerman, Taylor Eggertsen   +2 more
exaly   +4 more sources

Distinct classes of lamina-associated domains are defined by differential patterns of repressive histone methylation [PDF]

Genome Research
A large fraction of the genome interacts with the nuclear periphery through lamina-associated domains (LADs), repressive regions which play an important role in genome organization and gene regulation across development. Despite much work, LAD structure and regulation are not fully understood, and a mounting number of studies have identified numerous ...
Prabakaran Nagarajan, Mark Parthun, Benjamin Stanton   +2 more
exaly   +5 more sources

Laminopathy-causing lamin A mutations reconfigure lamina-associated domains and local spatial chromatin conformation [PDF]

Nucleus, 2018
The nuclear lamina contributes to the regulation of gene expression and to chromatin organization. Mutations in A-type nuclear lamins cause laminopathies, some of which are associated with a loss of heterochromatin at the nuclear periphery. Until recently however, little if any information has been provided on where and how lamin A interacts with the ...
Nolwenn Briand, Philippe Collas
exaly   +7 more sources

Revealing the biophysics of lamina-associated domain formation by integrating theoretical modeling and high-resolution imaging

Nature Communications
Chromatin-lamina interactions regulate gene activity by forming lamina-associated domains (LADs), which contribute to cellular identity through gene repression.
Monika Dhankhar, Zixian Guo, Aayush Kant, Ramin Basir, Rohit Joshi, Vinayak Vinayak, Su Chin Heo, Robert L. Mauck, Melike Lakadamyali, Vivek B. Shenoy   +9 more
doaj   +5 more sources

Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication [PDF]

, 1994
The major residual structure that remains associated with the nuclear envelope following extraction of isolated nuclei or oocyte germinal vesicles with non-ionic detergents, nucleases and high salt is the lamina (Fawcett, 1966; Aaronson and Blobel ...
Hutchison, CJ, Kill, IR, Bridger, JM, Cox, LS   +3 more
core   +6 more sources

Internal iamin structures within G1 nuclei of human dermal fibroblasts [PDF]

, 1993
The nuclear lamina is a mesh-like network of fibres subjacent to the inner nuclear membrane that is believed to be involved in the specific spatial reorganisation of chromatin after mitosis.
Kill, IR, Hutchison, CJ, O’Farrell, M, Bridger, JM   +3 more
core   +6 more sources

Mesoscale phase separation of chromatin in the nucleus

eLife, 2021
Intact-organism imaging of Drosophila larvae reveals and quantifies chromatin-aqueous phase separation. The chromatin can be organized near the lamina layer of the nuclear envelope, conventionally fill the nucleus, be organized centrally, or as a wetting
Gaurav Bajpai, Daria Amiad Pavlov, Dana Lorber, Talila Volk, Samuel Safran   +4 more
doaj   +1 more source