Gene Regulatory Interactions at Lamina-Associated Domains [PDF]
Genes, 2023 The nuclear lamina provides a repressive chromatin environment at the nuclear periphery. However, whereas most genes in lamina-associated domains (LADs) are inactive, over ten percent reside in local euchromatic contexts and are expressed. How these genes are regulated and whether they are able to interact with regulatory elements remain unclear. Here,
M Abdelhalim +2 more
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Revealing the biophysics of lamina-associated domain formation by integrating theoretical modeling and high-resolution imaging [PDF]
Nature CommunicationsChromatin-lamina interactions regulate gene activity by forming lamina-associated domains (LADs), which contribute to cellular identity through gene repression.
Monika Dhankhar +9 more
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Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression [PDF]
Cell, 2017 In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression.
Bas Van Steensel, Andrew Belmont
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Laminopathy-causing lamin A mutations reconfigure lamina-associated domains and local spatial chromatin conformation [PDF]
Nucleus, 2018 The nuclear lamina contributes to the regulation of gene expression and to chromatin organization. Mutations in A-type nuclear lamins cause laminopathies, some of which are associated with a loss of heterochromatin at the nuclear periphery. Until recently however, little if any information has been provided on where and how lamin A interacts with the ...
Nolwenn Briand, Philippe Collas
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Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains [PDF]
Nature Genetics, 2011 Extensive changes in DNA methylation are common in cancer and may contribute to oncogenesis through transcriptional silencing of tumor-suppressor genes. Genome-scale studies have yielded important insights into these changes but have focused on CpG islands or gene promoters.
Daniel Weisenberger +2 more
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Reorganization of lamina-associated domains in early mouse embryos is regulated by RNA polymerase II activity. [PDF]
Genes Dev, 2023 Fertilization in mammals is accompanied by an intense period of chromatin remodeling and major changes in nuclear organization. How the earliest events in embryogenesis, including zygotic genome activation (ZGA) during maternal-to-zygotic transition, influence such remodeling remains unknown.
Pal M +3 more
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Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease. [PDF]
Genome Res, 2022 Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in type 2 diabetes mellitus and the elderly, impacting 40% of individuals over 70. Regulation of heterochromatin at the nuclear lamina has been associated with aging and age-dependent metabolic changes. We previously showed that changes at the lamina in aged hepatocytes and laminopathy models
Wei X +6 more
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SUV family histone methyltransferases correlate with nuclear lamina remodeling and clinical outcome in cancer: integrative pan-cancer TCGA analysis and experimental evidence [PDF]
Scientific ReportsEpigenetic regulation of chromatin structure is a key determinant of transcriptional control and nuclear organization in cancer. Among histone lysine methyltransferases, SUV39H1 and SUV39H2 catalyze the trimethylation of histone H3 lysine 9 (H3K9me3 ...
Subhadip Kundu +3 more
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Distinct classes of lamina-associated domains are defined by differential patterns of repressive histone methylation. [PDF]
Genome ResA large fraction of the genome interacts with the nuclear periphery through lamina-associated domains (LADs), repressive regions which play an important role in genome organization and gene regulation across development. Despite much work, LAD structure and regulation are not fully understood, and a mounting number of studies have identified numerous ...
Martin CJ +6 more
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Mesoscale phase separation of chromatin in the nucleus
eLife, 2021 Intact-organism imaging of Drosophila larvae reveals and quantifies chromatin-aqueous phase separation. The chromatin can be organized near the lamina layer of the nuclear envelope, conventionally fill the nucleus, be organized centrally, or as a wetting
Gaurav Bajpai +4 more
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