Results 41 to 50 of about 8,868,086 (239)

Lack of evidence for sprouting of Aβ afferents into the superficial laminas of the spinal cord dorsal horn after nerve section [PDF]

, 2003
The central arborizations of large myelinated cutaneous afferents normally extend as far dorsally as the ventral part of lamina II in rat spinal cord. Woolf et al. (1992) reported that after nerve injury some of these afferents sprouted into lamina I and
Todd, A.J., Riddell, J.S., Dugald T. Scott, John S. Riddell, Andrew J. Todd, Scott, D.T., David I. Hughes, Hughes, D.I.   +7 more
core   +5 more sources

MAN1, an Inner Nuclear Membrane Protein That Shares the LEM Domain with Lamina-associated Polypeptide 2 and Emerin [PDF]

Journal of Biological Chemistry, 2000
The "MAN antigens" are polypeptides recognized by autoantibodies from a patient with a collagen vascular disease and localized to the nuclear envelope. We now show that one of the human MAN antigens termed MAN1 is a 82.3-kDa protein with an amino-terminal domain followed by two hydrophobic segments and a carboxyl-terminal tail.
F, Lin, D L, Blake, I, Callebaut, I S, Skerjanc, L, Holmer, M W, McBurney, M, Paulin-Levasseur, H J, Worman   +7 more
openaire   +2 more sources

Role of histone deacetylases in gene regulation at nuclear lamina.

PLoS ONE, 2012
Theoretical models suggest that gene silencing at the nuclear periphery may involve "closing" of chromatin by transcriptional repressors, such as histone deacetylases (HDACs). Here we provide experimental evidence confirming these predictions.
Beatrice C Milon, Haibo Cheng, Mikhail V Tselebrovsky, Sergei A Lavrov, Valentina V Nenasheva, Elena A Mikhaleva, Yuri Y Shevelyov, Dmitry I Nurminsky   +7 more
doaj   +1 more source

Hmga2 protein loss alters nuclear envelope and 3D chromatin structure

BMC Biology, 2022
Background The high-mobility group Hmga family of proteins are non-histone chromatin-interacting proteins which have been associated with a number of nuclear functions, including heterochromatin formation, replication, recombination, DNA repair ...
Giuseppina Divisato, Andrea M. Chiariello, Andrea Esposito, Pietro Zoppoli, Federico Zambelli, Maria Antonietta Elia, Graziano Pesole, Danny Incarnato, Fabiana Passaro, Silvia Piscitelli, Salvatore Oliviero, Mario Nicodemi, Silvia Parisi, Tommaso Russo   +13 more
doaj   +1 more source

Hotspots of De Novo Point Mutations in Induced Pluripotent Stem Cells

Cell Reports, 2017
Summary: Induced pluripotent stem cells (iPSCs) are generated by direct reprogramming of somatic cells and hold great promise for novel therapies. However, several studies have reported genetic variations in iPSC genomes.
Masahito Yoshihara, Ryoko Araki, Yasuji Kasama, Misato Sunayama, Masumi Abe, Kohji Nishida, Hideya Kawaji, Yoshihide Hayashizaki, Yasuhiro Murakawa   +8 more
doaj   +1 more source

Role of lamins in 3D genome organization and global gene expression

Nucleus, 2019
Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
doaj   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Additional file 1 of Lamina-associated domains: peripheral matters and internal affairs

, 2020
Additional file 1. Review history.
Briand, Nolwenn, Collas, Philippe
openaire   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source