Results 21 to 30 of about 8,868,086 (239)

Spatial and Genomic Correlates of HIV-1 Integration Site Targeting

Cells, 2022
HIV-1 integrase and capsid proteins interact with host proteins to direct preintegration complexes to active transcription units within gene-dense regions of chromosomes for viral DNA integration.
Parmit Kumar Singh, Gregory J. Bedwell, Alan N. Engelman   +2 more
doaj   +1 more source

Both emerin and lamin C depend on lamin A for localization at the nuclear envelope [PDF]

, 2001
Physical interactions between lamins and emerin were investigated by co-immunoprecipitation of in vitro translated proteins. Emerin interacted with in vitro translated lamins A, B1 and C in co-immunprecipitation reactions.
Whitfield, WGF, Vaughan, A, Hutchison, CJ, Wehnert, M, Bridger, JM, Morris, GE, Broers, JL, Raemakers, FC, Alvarez-Reyes, M   +8 more
core   +8 more sources

CTCF and cohesin promote focal detachment of DNA from the nuclear lamina

Genome Biology, 2022
Background Lamina-associated domains (LADs) are large genomic regions that are positioned at the nuclear lamina. It has remained largely unclear what drives the positioning and demarcation of LADs.
Tom van Schaik, Ning Qing Liu, Stefano G. Manzo, Daan Peric-Hupkes, Elzo de Wit, Bas van Steensel   +5 more
doaj   +1 more source

Genome organization in cardiomyocytes expressing mutated A-type lamins

Frontiers in Cell and Developmental Biology, 2022
Cardiomyopathy is a myocardial disorder, in which the heart muscle is structurally and functionally abnormal, often leading to heart failure. Dilated cardiomyopathy is characterized by a compromised left ventricular function and contributes significantly
Marie Kervella, Maureen Jahier, Albano C. Meli, Antoine Muchir   +3 more
doaj   +1 more source

An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype

Genome Biology, 2023
Background Association of chromatin with lamin proteins at the nuclear periphery has emerged as a potential mechanism to coordinate cell type-specific gene expression and maintain cellular identity via gene silencing.
Parisha P. Shah, Kathleen C. Keough, Ketrin Gjoni, Garrett T. Santini, Richard J. Abdill, Nadeera M. Wickramasinghe, Carolyn E. Dundes, Ashley Karnay, Angela Chen, Rachel E. A. Salomon, Patrick J. Walsh, Son C. Nguyen, Sean Whalen, Eric F. Joyce, Kyle M. Loh, Nicole Dubois, Katherine S. Pollard, Rajan Jain   +17 more
doaj   +1 more source

Biology and Model Predictions of the Dynamics and Heterogeneity of Chromatin-Nuclear Lamina Interactions

Frontiers in Cell and Developmental Biology, 2022
Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic ...
Julia Madsen-Østerbye, Aurélie Bellanger, Natalia M. Galigniana, Natalia M. Galigniana, Philippe Collas, Philippe Collas   +5 more
doaj   +1 more source

Identification of the lamina‐associated‐polypeptide‐2‐binding domain of B‐type lamin [PDF]

European Journal of Biochemistry, 1998
Lamina‐associated polypeptide (LAP)2, which directly interacts with B‐type lamins and chromosomes, is an integral membrane protein specifically distributed along the inner nuclear membrane of the nuclear envelope. Multiple regions of its large nucleoplasmic domain promote this localization, including the first (residues 1−296) and the second (residues ...
K, Furukawa, T, Kondo
openaire   +2 more sources

Nuclear lamins are not required for lamina‐associated domain organization in mouse embryonic stem cells [PDF]

The EMBO Reports, 2015
In mammals, the nuclear lamina interacts with hundreds of large genomic regions, termed lamina-associated domains (LADs) that are generally in a transcriptionally repressed state. Lamins form the major structural component of the lamina and have been reported to bind DNA and chromatin.
Amendola, Mario, van Steensel, Bas
openaire   +3 more sources

Agrin binds to the nerve-muscle basal lamina via laminin. [PDF]

, 1997
Agrin is a heparan sulfate proteoglycan that is required for the formation and maintenance of neuromuscular junctions. During development, agrin is secreted from motor neurons to trigger the local aggregation of acetylcholine receptors (AChRs) and other ...
Brandenberger, R, Ralph Brandenberger, Matthias Gesemann, Gesemann, M., Denzer, A. J., Chiquet, M, Ruegg, M. A., Denzer, A J, Brandenberger, R., Markus A. Ruegg, Matthias Chiquet, Gesemann, M, Ruegg, M A, Chiquet, M., Alain J. Denzer   +14 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation. [PDF]

FEBS Open Bio
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Nakajima S, Watanabe K, Sultanakhmetov G, Fukuchi A, Ito K, Shimizu S, Saito T, Asada A, Ando K.   +8 more
europepmc   +2 more sources