Results 21 to 30 of about 23,804 (222)
Spatial and Genomic Correlates of HIV-1 Integration Site Targeting
Cells, 2022 HIV-1 integrase and capsid proteins interact with host proteins to direct preintegration complexes to active transcription units within gene-dense regions of chromosomes for viral DNA integration.
Parmit Kumar Singh +2 more
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CTCF and cohesin promote focal detachment of DNA from the nuclear lamina
Genome Biology, 2022 Background Lamina-associated domains (LADs) are large genomic regions that are positioned at the nuclear lamina. It has remained largely unclear what drives the positioning and demarcation of LADs.
Tom van Schaik +5 more
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Genome organization in cardiomyocytes expressing mutated A-type lamins
Frontiers in Cell and Developmental Biology, 2022 Cardiomyopathy is a myocardial disorder, in which the heart muscle is structurally and functionally abnormal, often leading to heart failure. Dilated cardiomyopathy is characterized by a compromised left ventricular function and contributes significantly
Marie Kervella +3 more
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Frontiers in Cell and Developmental Biology, 2022 Associations of chromatin with the nuclear lamina, at the nuclear periphery, help shape the genome in 3 dimensions. The genomic landscape of lamina-associated domains (LADs) is well characterized, but much remains unknown on the physical and mechanistic ...
Julia Madsen-Østerbye +5 more
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Identification of the lamina‐associated‐polypeptide‐2‐binding domain of B‐type lamin [PDF]
European Journal of Biochemistry, 1998 Lamina‐associated polypeptide (LAP)2, which directly interacts with B‐type lamins and chromosomes, is an integral membrane protein specifically distributed along the inner nuclear membrane of the nuclear envelope. Multiple regions of its large nucleoplasmic domain promote this localization, including the first (residues 1−296) and the second (residues ...
K, Furukawa, T, Kondo
openaire +2 more sources
Genome Biology, 2023 Background Association of chromatin with lamin proteins at the nuclear periphery has emerged as a potential mechanism to coordinate cell type-specific gene expression and maintain cellular identity via gene silencing.
Parisha P. Shah +17 more
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BMC Genomics, 2020 Background Proximity ligation based techniques, like Hi-C, involve restriction digestion followed by ligation of formaldehyde cross-linked chromatin. Distinct chromatin states can impact the restriction digestion, and hence the visibility in the contact ...
Keerthivasan Raanin Chandradoss +7 more
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SHIELD: a platform for high-throughput screening of barrier-type DNA elements in human cells
Nature Communications, 2023 Chromatin boundary elements contribute to the partitioning of mammalian genomes into topological domains to regulate gene expression. Certain boundary elements are adopted as DNA insulators for safe and stable transgene expression in mammalian cells ...
Meng Zhang +5 more
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A genome-wide study on differential methylation in different cancers using TCGA database
Informatics in Medicine Unlocked, 2021 Background: DNA methylation is the main epigenetic mechanism driving changes in phenotype without altering genotype. Since the end of the seventies the role of methylation in cancer has become increasingly clear.
Daniele Santoni +2 more
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Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
Nature Communications, 2018 Lamina-associated domains (LADs) contact lamins in the nuclear lamina, and lamin B1 was thought to bind heterochromatic regions at the nuclear envelope.
Laura Pascual-Reguant +13 more
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