Results 11 to 20 of about 111,707 (190)
Autophagy mediates degradation of nuclear lamina [PDF]
Nature, 2015 Z.D. is supported by a fellow award from the Leukemia & Lymphoma Society. B.C.C. is supported by career development awards from the Dermatology Foundation, Melanoma Research Foundation, and American Skin Association. S.L.B., P.D.A. and R.M. are supported
A Freund +37 more
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Nuclear Envelope, Nuclear Lamina, and Inherited Disease [PDF]
, 2005 The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear pore complexes. In recent years, mutations in nuclear-envelope proteins have been shown to cause a surprisingly wide array of inherited diseases.
Courvalin, Jean-Claude, Worman, Howard,
core +8 more sources
The intriguing plant nuclear lamina [PDF]
Frontiers in Plant Science, 2014 The nuclear lamina is a complex protein mesh attached to the inner nuclear membrane, which is also associated with nuclear pore complexes. It provides mechanical support to the nucleus and nuclear envelope, and as well as facilitating the connection of ...
Malgorzata eCiska +1 more
doaj +4 more sources
The Nuclear Lamina: Protein Accumulation and Disease [PDF]
Biomedicines, 2020 Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging.
Carla Almendáriz-Palacios +7 more
doaj +3 more sources
Single-Cell Dynamics of Genome-Nuclear Lamina Interactions [PDF]
Cell, 2013 The nuclear lamina (NL) interacts with hundreds of large genomic regions termed lamina associated domains (LADs). The dynamics of these interactions and the relation to epigenetic modifications are poorly understood. We visualized the fate of LADs in single cells using a "molecular contact memory" approach.
Jop Kind, Ludo Pagie, Mario Amendola
exaly +4 more sources
Defective Nuclear Lamina in Aneuploidy and Carcinogenesis [PDF]
Frontiers in Oncology, 2018 Aneuploidy, loss or gain of whole chromosomes, is a prominent feature of carcinomas, and is generally considered to play an important role in the initiation and progression of cancer.
Elizabeth R. Smith +3 more
doaj +3 more sources
Cold Spring Harb Perspect Biol, 2022 Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear subcompartment, the nuclear lamina, that is involved in a variety of cellular processes such as the governance of nuclear integrity, nuclear positioning, mitosis, DNA ...
Wong X, Melendez-Perez AJ, Reddy KL.
europepmc +3 more sources
Microstructure‐based nuclear lamina constitutive model
Cytoskeleton, 2023 Abstract The nuclear lamina is widely recognized as the most crucial component in providing mechanical stability to the nucleus. However, it is still a significant challenge to model the mechanics of this multilayered protein network.
Nima Mostafazadeh, Zhangli Peng
openaire +2 more sources
Structural and Mechanical Aberrations of the Nuclear Lamina in Disease
Cells, 2020 The nuclear lamins are the major components of the nuclear lamina in the nuclear envelope. Lamins are involved in numerous functions, including a role in providing structural support to the cell and the mechanosensing of the cell.
Merel Stiekema +3 more
doaj +1 more source
Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation
Cells, 2020 Aging is characterized by the gradual loss of tissue function and integrity. Activation of inflammatory responses accelerates the deterioration of cells and tissues.
Lidya Kristiani, Miri Kim, Youngjo Kim
doaj +1 more source