Results 11 to 20 of about 59,822 (282)
Defective Nuclear Lamina in Aneuploidy and Carcinogenesis [PDF]
Frontiers in Oncology, 2018 Aneuploidy, loss or gain of whole chromosomes, is a prominent feature of carcinomas, and is generally considered to play an important role in the initiation and progression of cancer.
Elizabeth R. Smith +3 more
doaj +7 more sources
Mapping the micro-proteome of the nuclear lamina and lamina-associated domains [PDF]
Life Science Alliance, 2021 The nuclear lamina provides structure to the nucleus and serves as an interface between the cytoskeleton and large heterochromatin domains called LADs. This study describes the microproteome of this LAD/lamina interface.
Xianrong Wong +6 more
doaj +4 more sources
The Nuclear Lamina: Protein Accumulation and Disease [PDF]
Biomedicines, 2020 Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging.
Carla Almendáriz-Palacios +7 more
doaj +3 more sources
Baculovirus infection induces disruption of the nuclear lamina [PDF]
Scientific Reports, 2017 Baculovirus nucleocapsids egress from the nucleus primarily via budding at the nuclear membrane. The nuclear lamina underlying the nuclear membrane represents a substantial barrier to nuclear egress. Whether the nuclear lamina undergoes disruption during
Xiaomei Zhang +5 more
doaj +2 more sources
The Human Protein PRR14 Tethers Heterochromatin to the Nuclear Lamina during Interphase and Mitotic Exit [PDF]
Cell Reports, 2013 The nuclear lamina is a protein meshwork that lies under the inner nuclear membrane of metazoan cells. One function of the nuclear lamina is to organize heterochromatin at the inner nuclear periphery.
Andrey Poleshko +5 more
doaj +2 more sources
Reorganization of the nuclear lamina and cytoskeleton in adipogenesis [PDF]
Histochemistry and Cell Biology, 2011 A thorough understanding of fat cell biology is necessary to counter the epidemic of obesity. Although molecular pathways governing adipogenesis are well delineated, the structure of the nuclear lamina and nuclear-cytoskeleton junction in this process are not.
Verstraeten, V.L. +9 more
openaire +5 more sources
Nuclear Envelope, Nuclear Lamina, and Inherited Disease [PDF]
, 2005 The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear pore complexes. In recent years, mutations in nuclear-envelope proteins have been shown to cause a surprisingly wide array of inherited diseases. While the mutant proteins are generally expressed in most or all differentiated somatic cells, many mutations cause ...
Worman, Howard, Courvalin, Jean-Claude
openaire +6 more sources
Assembly-disassembly of the nuclear lamina [PDF]
Current Opinion in Cell Biology, 1992 Recently, progress in the study of lamins has been made in three areas: signals required for targetting newly synthesized lamins to the correct subnuclear compartment have been identified; information on lamina assembly has been obtained from in vitro studies using bacterially expressed proteins; and a mechanistic explanation for how the nuclear lamina
Nigg, E. A.
openaire +3 more sources
The nuclear lamina and heterochromatin: a complex relationship [PDF]
Biochemical Society Transactions, 2011 In metazoan cells, the heterochromatin is generally localized at the nuclear periphery, whereas active genes are preferentially found in the nuclear interior. In the present paper, we review current evidence showing that components of the nuclear lamina interact directly with heterochromatin, which implicates the nuclear lamina in a mechanism of ...
Erin M, Bank, Yosef, Gruenbaum
openaire +3 more sources
Cold Spring Harb Perspect Biol, 2022 Lamins interact with a host of nuclear membrane proteins, transcription factors, chromatin regulators, signaling molecules, splicing factors, and even chromatin itself to form a nuclear subcompartment, the nuclear lamina, that is involved in a variety of cellular processes such as the governance of nuclear integrity, nuclear positioning, mitosis, DNA ...
Wong X, Melendez-Perez AJ, Reddy KL.
europepmc +3 more sources