Results 31 to 40 of about 1,508,553 (267)
Chromosome length and gene density contribute to micronuclear membrane stability
Life Science Alliance, 2022 Chromosome identity regulates the timing of nuclear membrane rupture in micronuclei, in part through an unexpected link between high gene density and improved nuclear lamina organization.
Anna E Mammel +4 more
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Photonics, 2020 Studying the architecture of nuclear lamina networks is significantly important in biomedicine owing not only to their influence on the genome, but also because they are associated with several diseases.
Yiwei Chen +8 more
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Nuclear Envelope, Nuclear Lamina, and Inherited Disease [PDF]
, 2005 The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear pore complexes. In recent years, mutations in nuclear-envelope proteins have been shown to cause a surprisingly wide array of inherited diseases. While the mutant proteins are generally expressed in most or all differentiated somatic cells, many mutations cause ...
Worman, Howard, Courvalin, Jean-Claude
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Role of lamins in 3D genome organization and global gene expression
Nucleus, 2019 Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina.
Youngjo Kim, Xiaobin Zheng, Yixian Zheng
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Remodeling of the Nuclear Envelope and Lamina during Bovine Preimplantation Development and Its Functional Implications. [PDF]
PLoS ONE, 2015 The present study demonstrates a major remodeling of the nuclear envelope and its underlying lamina during bovine preimplantation development. Up to the onset of major embryonic genome activation (MGA) at the 8-cell stage nuclei showed a non-uniform ...
Jens Popken +9 more
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3D Single Molecule Super-Resolution Microscopy of Whole Nuclear Lamina
Frontiers in Chemistry, 2022 Single molecule (SM) super-resolution microscopies bypass the diffraction limit of conventional optical techniques and provide excellent spatial resolutions in the tens of nanometers without overly complex microscope hardware.
Ashley M. Rozario +7 more
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The FEBS Journal, 2007 The inner face of the nuclear envelope of metazoan cells is covered by a thin lamina consisting of a one‐layered network of intermediate filaments interconnecting with a complex set of transmembrane proteins and chromatin associating factors. The constituent proteins, the lamins, have recently gained tremendous recognition, because mutations in the ...
Joanna M, Bridger +3 more
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Restructuring of Lamina-Associated Domains in Senescence and Cancer
Cells, 2022 Induction of cellular senescence or cancer is associated with a reshaping of the nuclear envelope and a broad reorganization of heterochromatin. At the periphery of mammalian nuclei, heterochromatin is stabilized at the nuclear lamina via lamina ...
Aurélie Bellanger +3 more
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Reorganization of the nuclear lamina and cytoskeleton in adipogenesis [PDF]
Histochemistry and Cell Biology, 2011 A thorough understanding of fat cell biology is necessary to counter the epidemic of obesity. Although molecular pathways governing adipogenesis are well delineated, the structure of the nuclear lamina and nuclear-cytoskeleton junction in this process are not.
Verstraeten, V.L. +9 more
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PLoS Genetics, 2013 The nuclear lamina is the structural scaffold of the nuclear envelope and is well known for its central role in nuclear organization and maintaining nuclear stability and shape.
Jana Link +7 more
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