Results 1 to 10 of about 4,081 (158)

Depletion of SUN1/2 induces heterochromatin accrual in mesenchymal stem cells during adipogenesis [PDF]

Communications Biology, 2022
Critical to the mechano-regulation of mesenchymal stem cells (MSC), Linker of the Nucleoskeleton and Cytoskeleton (LINC) complex transduces cytoskeletal forces to the nuclei.
Matthew Goelzer, Sean Howard, Anamaria G. Zavala, Daniel Conway, Janet Rubin, Andre J. van Wijnen, Gunes Uzer   +6 more
doaj   +5 more sources

A Mechano-Feedback Loop Orchestrated by SUN1/2 Governs Cellular Mechanoadaptation via Lamina-Associated Domain Remodeling [PDF]

Research
SUN1/2, core components of the linker of nucleoskeleton and cytoskeleton complex, transmit extracellular mechanical forces to nuclear lamina and chromatin.
Yafan Xie, Zhaoyan Zuo, Chenfei Lu, Yanjing Zhao, Liping Guo, Wei Xu, Fuhai Liu, Robert Guidoin, Haoyue Zhang, Juhui Qiu, Guixue Wang, Qin Peng   +11 more
doaj   +2 more sources

Elevated SUN1 promotes migratory cell polarity defects through mechanically coupling microtubules to the nuclear lamina [PDF]

Communications Biology
In migratory fibroblasts, front-rear polarity is defined by the centrosome positioned anterior to a rearward nucleus. To achieve this polarity, actin cables couple to nuclear membrane proteins nesprin-2G and SUN2 and drive the nucleus backward.
Yutao Li, Yicong Zhang, Mengqi Chen, Susumu Antoku, Junjun Ding, Kaiyao Huang, Gregg G. Gundersen, Wakam Chang   +7 more
doaj   +2 more sources

Tethering of Telomeres to the Nuclear Envelope Is Mediated by SUN1-MAJIN and Possibly Promoted by SPDYA-CDK2 During Meiosis

Frontiers in Cell and Developmental Biology, 2020
During meiosis, telomeres attach to the nuclear envelope (NE) to promote homologous chromosome moving, pairing, synapsis, and recombination. The telomere-NE attachment is mediated by SUN1, TERB1-TERB2-MAJIN (TTM complex), and TRF1. The interaction of the
Fei Sun, Guishuan Wang, Xiaolong Wu
exaly   +3 more sources

SV40 exploits the Nesprin-2-SUN1-KPNA4 axis for stepwise targeting and entry into the host nucleus to promote infection. [PDF]

PLoS Pathogens
Many DNA viruses including polyomaviruses (PyVs) enter the host nucleus to cause infection, although how this is accomplished is unclear. To infect cells, the prototype PyV SV40 targets to the Nesprin-2 outer nuclear membrane protein and enters the ...
Luke Gohmann, Billy Tsai
doaj   +2 more sources

A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei [PDF]

eLife
Mitosis in eukaryotes involves reorganisation of the nuclear envelope (NE) and microtubule-organising centres (MTOCs). During male gametogenesis in Plasmodium, the causative agent of malaria, mitosis is exceptionally rapid and highly divergent.
Mohammad Zeeshan, Igor Blatov, Ryuji Yanase, David JP Ferguson, Sarah L Pashley, Zeinab Chahine, Yoshiki Yamaryo-Botté, Akancha Mishra, Baptiste Marche, Suhani Bhanvadia, Molly Hair, Sagar Batra, Robert Markus, Declan Brady, Andrew R Bottrill, Sue Vaughan, Cyrille Y Botté, Karine G Le Roch, Anthony A Holder, Eelco Tromer, Rita Tewari   +20 more
doaj   +2 more sources

A dual-reporter mouse for therapeutic discovery in Angelman syndrome [PDF]

JCI Insight
Angelman syndrome is a neurodevelopmental disorder caused by loss of the maternal UBE3A allele, the sole source of UBE3A in mature neurons owing to epigenetic silencing of the paternal allele.
Hanna Vihma, Lucas M. James, Hannah C. Nourie, Audrey L. Smith, Siyuan Liang, Carlee A. Friar, Tasmai Vulli, Lei Xing, Dale O. Cowley, Alain C. Burette, Benjamin D. Philpot   +10 more
doaj   +2 more sources

Tension-sensitive LINC-RhoA signaling prevents chromatin bridge breakage in cytokinesis [PDF]

The EMBO Journal
In the presence of chromatin bridges in cytokinesis, human cells retain actin-rich structures (actin patches) at the base of the intercellular canal to prevent chromosome breakage.
Sofia Balafouti, Maria Kabouraki, George Zachos, Eleni Petsalaki   +3 more
doaj   +2 more sources

Dictyostelium spastin is involved in nuclear envelope dynamics during semi-closed mitosis

Nucleus, 2022
Dictyostelium amoebae perform a semi-closed mitosis, in which the nuclear envelope is fenestrated at the insertion sites of the mitotic centrosomes and around the central spindle during karyokinesis.
Ulrike Schweigel, Petros Batsios, Annette Müller-Taubenberger, Ralph Gräf, Marianne Grafe   +4 more
doaj   +1 more source

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

eLife, 2023
Endothelial cells line all blood vessels, where they coordinate blood vessel formation and the blood-tissue barrier via regulation of cell-cell junctions.
Danielle B Buglak, Pauline Bougaran, Molly R Kulikauskas, Ziqing Liu, Elizabeth Monaghan-Benson, Ariel L Gold, Allison P Marvin, Andrew Burciu, Natalie T Tanke, Morgan Oatley, Shea N Ricketts, Karina Kinghorn, Bryan N Johnson, Celia E Shiau, Stephen Rogers, Christophe Guilluy, Victoria L Bautch   +16 more
doaj   +1 more source