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The nuclear envelope localization of DYT1 dystonia torsinA-ΔE requires the SUN1 LINC complex component [PDF]
BMC Cell Biology, 2011 Background DYT1 dystonia is an autosomal dominant neurological condition caused by a mutation that removes a single glutamic acid residue (ΔE) from the torsinA (torA) AAA+ protein.
Jeong Danielle Y +3 more
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Dialing Down SUN1 for Laminopathies [PDF]
Cell, 2012 Laminopathies, caused by mutations in A-type nuclear lamins, encompass a range of diseases, including forms of progeria and muscular dystrophy. In this issue, Chen et al. provide evidence that elevated expression of the nuclear inner membrane protein SUN1 drives pathology in multiple laminopathies.
Suh, Yousin, Kennedy, Brian K.
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Functional association of Sun1 with nuclear pore complexes [PDF]
The Journal of Cell Biology, 2007 Sun1 and 2 are A-type lamin-binding proteins that, in association with nesprins, form a link between the inner nuclear membranes (INMs) and outer nuclear membranes of mammalian nuclear envelopes. Both immunofluorescence and immunoelectron microscopy reveal that Sun1 but not Sun2 is intimately associated with nuclear pore complexes (NPCs).
Liu, Qian +7 more
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Cell Reports, 2021 Summary: The human immunodeficiency virus (HIV) enters the nucleus to establish infection, but the role of nuclear envelope proteins in this process is incompletely understood.
Anvita Bhargava +7 more
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Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression. [PDF]
PLoS ONE, 2018 LInkers of Nucleoskeleton and Cytoskeleton (LINC) complexes, composed of SUN and KASH-domain proteins, span the nuclear envelope and physically connect the nuclear interior to cytoskeletal elements.
Christopher K May, Christopher W Carroll
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Heliyon, 2022 Formation of robust actomyosin stress fibers (SF) in response to cell stretch plays a key role in the transfer of information from the cytoplasm into the nucleus.
Mark A. Smith +5 more
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The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal
Scientific Reports, 2021 The morphology of the Golgi complex is influenced by the cellular context, which strictly correlates with nuclear functions; however, the mechanism underlying this association remains elusive.
Miki Hieda +11 more
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Molecular Insights into the Mechanisms of SUN1 Oligomerization in the Nuclear Envelope [PDF]
Biophysical Journal, 2018 The LINC complex is found in a wide variety of organisms and is formed by the transluminal interaction between outer- and inner-nuclear-membrane KASH and SUN proteins, respectively. Most extensively studied are SUN1 and SUN2 proteins, which are widely expressed in mammals.
Jahed, Zeinab +5 more
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Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA [PDF]
Development, 2009 The inner nuclear envelope (NE) proteins interact with the nuclear lamina and participate in the architectural compartmentalization of chromosomes. The association of NE proteins with DNA contributes to the spatial rearrangement of chromosomes and their gene expression.
Ya-Hui, Chi +8 more
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Frontiers in Cell and Developmental Biology, 2023 The LINC complex, consisting of interacting SUN and KASH proteins, mechanically couples nuclear contents to the cytoskeleton. In meiosis, the LINC complex transmits microtubule-generated forces to chromosome ends, driving the rapid chromosome movements ...
Manickam Gurusaran +3 more
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