Results 31 to 40 of about 4,081 (158)

Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy

Nature Communications, 2021
Mutations in the LaminA gene are the second most common inherited cause of Dilated Cardiomyopathy, a major form of heart failure. Here the authors show that disruption of the nuclear protein SUN1 in cardiomyocytes, by AAV mediated transduction of a SUN1 ...
Ruth Jinfen Chai, Hendrikje Werner, Peter Yiqing Li, Yin Loon Lee, Khaing Thet Nyein, Irina Solovei, Tuan Danh Anh Luu, Bhavya Sharma, Raju Navasankari, Martina Maric, Lois Yu En Sim, Ying Jie Loh, Edita Aliwarga, Jason Wen Long Cheong, Alexandre Chojnowski, Matias Ilmari Autio, Yu Haiyang, Kenneth Kian Boon Tan, Choong Tat Keng, Shi Ling Ng, Wei Leong Chew, Michael Ferenczi, Brian Burke, Roger Sik Yin Foo, Colin L. Stewart   +24 more
doaj   +1 more source

Expression of individual mammalian Sun1 isoforms depends on the cell type [PDF]

Communicative & Integrative Biology, 2011
Mammalian Sun1 belongs to an evolutionarily conserved family of inner nuclear membrane proteins, which are known as SUN domain proteins. SUN domain proteins interact with KASH domain partners to form bridging complexes, so-called LINC complexes, that physically connect the nuclear interior to the cytoskeleton.
Göb, Eva, Meyer-Natus, Elisabeth, Benavente, Ricardo, Alsheimer, Manfred   +3 more
openaire   +3 more sources

SUN1 Is Required for Telomere Attachment to Nuclear Envelope and Gametogenesis in Mice [PDF]

Developmental Cell, 2007
Prior to the pairing and recombination between homologous chromosomes during meiosis, telomeres attach to the nuclear envelope and form a transient cluster. However, the protein factors mediating meiotic telomere attachment to the nuclear envelope and the requirement of this attachment for homolog pairing and synapsis have not been determined in ...
Ding, Xu, Xu, Rener, Yu, Juehua, Xu, Tian, Zhuang, Yuan, Han, Min   +5 more
openaire   +2 more sources

Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function.

PLoS Genetics, 2014
LINC complexes are evolutionarily conserved nuclear envelope bridges, composed of SUN (Sad-1/UNC-84) and KASH (Klarsicht/ANC-1/Syne/homology) domain proteins.
Jana Link, Monika Leubner, Johannes Schmitt, Eva Göb, Ricardo Benavente, Kuan-Teh Jeang, Rener Xu, Manfred Alsheimer   +7 more
doaj   +1 more source

Loss of the integral nuclear envelope protein SUN1 induces alteration of nucleoli [PDF]

Nucleus, 2016
A supervised machine learning algorithm, which is qualified for image classification and analyzing similarities, is based on multiple discriminative morphological features that are automatically assembled during the learning processes. The algorithm is suitable for population-based analysis of images of biological materials that are generally complex ...
Ayaka, Matsumoto, Chiyomi, Sakamoto, Haruka, Matsumori, Jun, Katahira, Yoko, Yasuda, Katsuhide, Yoshidome, Masahiko, Tsujimoto, Ilya G, Goldberg, Nariaki, Matsuura, Mitsuyoshi, Nakao, Noriko, Saitoh, Miki, Hieda   +11 more
openaire   +2 more sources

SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells

Cells, 2020
Vascular smooth muscle cells (VSMCs) are the predominant cell type in the blood vessel wall. Changes in VSMC actomyosin activity and morphology are prevalent in cardiovascular disease. The actin cytoskeleton actively defines cellular shape and the LInker
Lauren Porter, Rose-Marie Minaisah, Sultan Ahmed, Seema Ali, Rosemary Norton, Qiuping Zhang, Elisa Ferraro, Chris Molenaar, Mark Holt, Susan Cox, Samuel Fountain, Catherine Shanahan, Derek Warren   +12 more
doaj   +1 more source

POM121 and Sun1 play a role in early steps of interphase NPC assembly [PDF]

Journal of Cell Biology, 2011
Nuclear pore complexes (NPCs) assemble at the end of mitosis during nuclear envelope (NE) reformation and into an intact NE as cells progress through interphase. Although recent studies have shown that NPC formation occurs by two different molecular mechanisms at two distinct cell cycle stages, little is known about the molecular players that mediate ...
Talamas, Jessica A., Hetzer, Martin W.
openaire   +2 more sources

The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction

Communications Biology, 2022
The transcription factor PREP1 binds to promoter regions of SUN1, SUN2 and LAP2 genes and promotes nuclear stiffness, and its depletion results in impaired mechanotransduction.
Divya Purushothaman, Laura F. Bianchi, Dmitry Penkov, Alessandro Poli, Qingsen Li, Jelena Vermezovic, Francesca M. Pramotton, Ramveer Choudhary, Fabrizio A. Pennacchio, Elena Sommariva, Marco Foiani, Nils Gauthier, Paolo Maiuri, Francesco Blasi   +13 more
doaj   +1 more source

Effect of fluid fl ow on solidifi ed equiaxed dendrite morphology evolution based on phase fi eld - lattice Boltzmann method [PDF]

China Foundry, 2018
Fluid fl ow can signifi cantly change the evolution of microstructural morphology. However, relatively little is known how the fluid flow, concentration and microstructure affect each other quantitatively, which is essential to optimize processing ...
Wei-zhao Sun1, Rui Yan1, Xiong Wan1
doaj   +1 more source

Brightness Characterization of SUN1 and SUN2 by Z-Scan Fluorescence Fluctuation Spectroscopy [PDF]

Biophysical Journal, 2016
Fluorescence fluctuation spectroscopy (FFS) has been used to quantify the stoichiometry of soluble proteins in the cytoplasm of cells by brightness analysis. The development of z-scan FFS broadened the capability of brightness analysis to include proteins distributed across stratified layers, such as the cytoplasm and the plasma membrane.
Saunders, Cosmo A., Hennen, Jared, Smith, Elizabeth M., Mueller, Joachim D., Luxton, G.W. Gant   +4 more
openaire   +1 more source