Results 11 to 20 of about 4,081 (158)
Nuclear restriction of HIV-1 infection by SUN1 [PDF]
Scientific Reports, 2021 Overexpression of the human Sad-1-Unc-84 homology protein 2 (SUN2) blocks HIV-1 infection in a capsid-dependent manner. In agreement, we showed that overexpression of SUN1 (Sad1 and UNC-84a) also blocks HIV-1 infection in a capsid-dependent manner.
Mirjana Persaud +6 more
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Data on the association of the nuclear envelope protein Sun1 with nucleoli
Data in Brief, 2017 SUN proteins participate in diverse cellular activities, many of which are connected to the nuclear envelope. Recently, the family member SUN1 has been linked to novel biological activities.
Ossama Moujaber +6 more
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Sun1 deficiency leads to cerebellar ataxia in mice [PDF]
Disease Models & Mechanisms, 2015 Migration and organization of the nucleus are essential for the proliferation and differentiation of cells, including neurons. However, the relationship between the positioning of the nucleus and cellular morphogenesis remains poorly understood ...
Jing-Ya Wang +7 more
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SUN1/2 controls macrophage polarization via modulating nuclear size and stiffness
Nature Communications, 2023 Alteration of the size and stiffness of the nucleus triggered by environmental cues are thought to be important for eukaryotic cell fate and function.
Shi Jiao +10 more
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Frontiers in Cell and Developmental Biology, 2022 The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the inner nuclear membrane-spanning SUN proteins and the outer nuclear membrane-spanning nesprin proteins.
Nanami Ueda +11 more
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The function of the inner nuclear envelope protein SUN1 in mRNA export is regulated by phosphorylation [PDF]
Scientific Reports, 2017 SUN1, a component of the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, functions in mammalian mRNA export through the NXF1-dependent pathway. It associates with mRNP complexes by direct interaction with NXF1.
Ping Li +5 more
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From loss to gain: role for SUN1 in laminopathies [PDF]
Cell & Bioscience, 2012 Mutations in LMNA encoding lamins A and C are associated with at least 10 different degenerative disorders affecting diverse tissues, collectively called laminopathies.
Liu Baohua, Jin Dong-Yan, Zhou Zhongjun
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The SUN1-SPDYA interaction plays an essential role in meiosis prophase I [PDF]
Nature Communications, 2021 Telomeres attach to the nuclear envelope to facilitate homolog pairing during meiosis prophase I. Here, the authors show that SUN1 and SPDYA interact, and demonstrate that this interaction is important for telomere structure and function, and essential ...
Yanyan Chen +13 more
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Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization. [PDF]
PLoS Genetics, 2014 Proteins of the nuclear envelope (NE) are associated with a range of inherited disorders, most commonly involving muscular dystrophy and cardiomyopathy, as exemplified by Emery-Dreifuss muscular dystrophy (EDMD).
Peter Meinke +10 more
doaj +7 more sources
eLife, 2019 Here we show that a major muscle specific isoform of the murine LINC complex protein SUN1 is required for efficient muscle regeneration. The nucleoplasmic domain of the isoform specifically binds to and inhibits Drosha, a key component of the ...
Tsui Han Loo +6 more
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