Building and breaking mechanical bridges between the nucleus and cytoskeleton: Regulation of LINC complex assembly and disassembly. [PDF]
Curr Opin Cell Biol, 2023 The nucleus is physically coupled to the cytoskeleton through LINC complexes, macromolecular bridges composed of SUN and KASH proteins that span the nuclear envelope. LINC complexes are involved in a wide variety of critical cellular processes. For these
McGillivary RM, Starr DA, Luxton GWG.
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BMC Cell Biology, 2011 Background DYT1 dystonia is an autosomal dominant neurological condition caused by a mutation that removes a single glutamic acid residue (ΔE) from the torsinA (torA) AAA+ protein.
Jeong Danielle Y +3 more
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Molecular insights into LINC complex architecture through the crystal structure of a luminal trimeric coiled-coil domain of SUN1. [PDF]
Front Cell Dev Biol, 2023 The LINC complex, consisting of interacting SUN and KASH proteins, mechanically couples nuclear contents to the cytoskeleton. In meiosis, the LINC complex transmits microtubule-generated forces to chromosome ends, driving the rapid chromosome movements ...
Gurusaran M +3 more
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Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast. [PDF]
Life Sci Alliance, 2020 The canonical LINC complex is composed of two different transmembrane proteins; this work reveals the heterotrimeric composition of the telomere-associated LINC complex in budding yeast. The linker of the nucleoskeleton and cytoskeleton (LINC) complex is
Fan J, Jin H, Koch BA, Yu HG.
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Molecular tension microscopy of the LINC complex in live cells. [PDF]
STAR Protoc, 2022 We present a protocol to measure the effect of pharmacological treatments on the mechanical tension experienced by nesprins at the cytoplasmic surface of the nuclear envelope of mammalian cells in culture. We apply this protocol to MDCK epithelial cells exposed to the actin depolymerization agent cytochalasin D.
Sipieter F +3 more
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Disulfide bond in SUN2 regulates dynamic remodeling of LINC complexes at the nuclear envelope
Life Science Alliance, 2023 The LINC complex tethers the cell nucleus to the cytoskeleton to regulate mechanical forces during cell migration, differentiation, and various diseases.
Rahul Sharma, Martin W Hetzer
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A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies. [PDF]
Elife, 2021 The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex mechanically couples cytoskeletal and nuclear components across the nuclear envelope to fulfil a myriad of cellular functions, including nuclear shape and positioning, hearing, and meiotic ...
Gurusaran M, Davies OR.
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The LINC complex is essential for hearing [PDF]
Journal of Clinical Investigation, 2013 Hereditary hearing loss is the most common sensory deficit. We determined that progressive high-frequency hearing loss in 2 families of Iraqi Jewish ancestry was due to homozygosity for the protein truncating mutation SYNE4 c.228delAT. SYNE4, a gene not previously associated with hearing loss, encodes nesprin-4 (NESP4), an outer nuclear membrane (ONM ...
Henning F, Horn +13 more
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The cytoskeleton dynamics-dependent LINC complex in periodontal ligament stem cells transmits mechanical stress to the nuclear envelope and promotes YAP nuclear translocation. [PDF]
Stem Cell Res TherBackground Periodontal ligament stem cells (PDLSCs) are important seed cells in tissue engineering and clinical applications. They are the priority receptor cells for sensing various mechanical stresses.
Meng X +9 more
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Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression. [PDF]
PLoS ONE, 2018 LInkers of Nucleoskeleton and Cytoskeleton (LINC) complexes, composed of SUN and KASH-domain proteins, span the nuclear envelope and physically connect the nuclear interior to cytoskeletal elements.
Christopher K May, Christopher W Carroll
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