Results 21 to 30 of about 7,490 (198)
Diverse Roles of the LINC Complex in Cellular Function and Disease in the Nervous System [PDF]
International Journal of Molecular SciencesKen-Ichiro Kuwako
exaly +2 more sources
Disulfide bond in SUN2 regulates dynamic remodeling of LINC complexes at the nuclear envelope
Life Science Alliance, 2023 The LINC complex tethers the cell nucleus to the cytoskeleton to regulate mechanical forces during cell migration, differentiation, and various diseases.
Rahul Sharma, Martin W Hetzer
doaj +1 more source
Molecular tension microscopy of the LINC complex in live cells. [PDF]
STAR Protoc, 2022 We present a protocol to measure the effect of pharmacological treatments on the mechanical tension experienced by nesprins at the cytoplasmic surface of the nuclear envelope of mammalian cells in culture. We apply this protocol to MDCK epithelial cells exposed to the actin depolymerization agent cytochalasin D.
Sipieter F +3 more
europepmc +5 more sources
Changes in Nuclear Shape and Gene Expression in Response to Simulated Microgravity Are LINC Complex-Dependent [PDF]
International Journal of Molecular Sciences, 2020 Richard Barker +2 more
exaly +2 more sources
The LINC complex is essential for hearing [PDF]
Journal of Clinical Investigation, 2013 Hereditary hearing loss is the most common sensory deficit. We determined that progressive high-frequency hearing loss in 2 families of Iraqi Jewish ancestry was due to homozygosity for the protein truncating mutation SYNE4 c.228delAT. SYNE4, a gene not previously associated with hearing loss, encodes nesprin-4 (NESP4), an outer nuclear membrane (ONM ...
Henning F, Horn +13 more
openaire +2 more sources
LINC complexes in health and disease [PDF]
Nucleus, 2010 The cell nucleus communicates with the rest of the cell via nucleo/cytoplasmic transport of proteins and RNA through the nuclear pores. Direct mechanical links between the nucleus and the cytoplasm have recently emerged in the form of LINC (Linkers of the nucleoskeleton to the cytoskeleton) protein complexes. A LINC complex consists of four components.
Mejat, Alexandre, Misteli, Tom
openaire +3 more sources
Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression. [PDF]
PLoS ONE, 2018 LInkers of Nucleoskeleton and Cytoskeleton (LINC) complexes, composed of SUN and KASH-domain proteins, span the nuclear envelope and physically connect the nuclear interior to cytoskeletal elements.
Christopher K May, Christopher W Carroll
doaj +1 more source
Structural insights into LINC complexes [PDF]
Current Opinion in Structural Biology, 2013 Communication between nucleus and cytoplasm extends past molecular exchange and critically includes mechanical wiring. Cytoskeleton and nucleoskeleton are connected via molecular tethers that span the nuclear envelope. Sad1, UNC84 (SUN)-domain proteins spanning the inner nuclear membrane and Klarsicht, ANC-1 and SYNE/Nesprin-1 and -2 Homology (KASH ...
Kutay, Ulrike +2 more
openaire +5 more sources
Frontiers in Plant Science, 2021 In eukaryotes, the nuclear envelope (NE) encloses chromatin and separates it from the rest of the cell. The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex physically bridges across the NE, linking nuclear and cytoplasmic components.
Joseph F. McKenna +6 more
doaj +1 more source
SWR1-Independent Association of H2A.Z to the LINC Complex Promotes Meiotic Chromosome Motion [PDF]
Frontiers in Cell and Developmental Biology, 2020 Sue Jaspersen +2 more
exaly +2 more sources