The LINC complex and human disease
Biochemical Society Transactions, 2011 The LINC (linker of nucleoskeleton and cytoskeleton) complex is a proposed mechanical link tethering the nucleo- and cyto-skeleton via the NE (nuclear envelope). The LINC components emerin, lamin A/C, SUN1, SUN2, nesprin-1 and nesprin-2 interact with each other at the NE and also with other binding partners including actin filaments and B-type lamins ...
Peter, Meinke +2 more
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Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction [PDF]
EMBO ReportsBrain aging is an intricate process that inevitably leads to functional deterioration. However, its molecular drivers remain unclear. Here, we show that the age-related decline in LINC complex expression on the neuronal nuclear envelope impairs axon ...
Koichi Hasegawa +15 more
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Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast [PDF]
Life Science Alliance, 2020 The canonical LINC complex is composed of two different transmembrane proteins; this work reveals the heterotrimeric composition of the telomere-associated LINC complex in budding yeast. The linker of the nucleoskeleton and cytoskeleton (LINC) complex is
Jinbo Fan +3 more
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Changes in Nuclear Shape and Gene Expression in Response to Simulated Microgravity Are LINC Complex-Dependent. [PDF]
Int J Mol Sci, 2020 Microgravity is known to affect the organization of the cytoskeleton, cell and nuclear morphology and to elicit differential expression of genes associated with the cytoskeleton, focal adhesions and the extracellular matrix.
Neelam S +7 more
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A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies [PDF]
eLife, 2021 The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex mechanically couples cytoskeletal and nuclear components across the nuclear envelope to fulfil a myriad of cellular functions, including nuclear shape and positioning, hearing, and meiotic ...
Manickam Gurusaran, Owen Richard Davies
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Implications for Diverse Functions of the LINC Complexes Based on the Structure [PDF]
Cells, 2017 The linker of nucleoskeleton and cytoskeleton (LINC) complex is composed of the outer and inner nuclear membrane protein families Klarsicht, Anc-1, and Syne homology (KASH), and Sad1 and UNC-84 (SUN) homology domain proteins.
Miki Hieda
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Inhibition of PDIs Downregulates Core LINC Complex Proteins, Promoting the Invasiveness of MDA-MB-231 Breast Cancer Cells in Confined Spaces In Vitro [PDF]
CellsEukaryotic cells tether the nucleoskeleton to the cytoskeleton via a conserved molecular bridge, called the LINC complex. The core of the LINC complex comprises SUN-domain and KASH-domain proteins that directly associate within the nuclear envelope lumen.
Natalie Young +11 more
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The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation [PDF]
eLife, 2021 While the mechanisms by which chemical signals control cell fate have been well studied, the impact of mechanical inputs on cell fate decisions is not well understood.
Emma Carley +8 more
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The cytoskeleton dynamics-dependent LINC complex in periodontal ligament stem cells transmits mechanical stress to the nuclear envelope and promotes YAP nuclear translocation [PDF]
Stem Cell Research & TherapyBackground Periodontal ligament stem cells (PDLSCs) are important seed cells in tissue engineering and clinical applications. They are the priority receptor cells for sensing various mechanical stresses.
Xuehuan Meng +9 more
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Prrx1-driven LINC complex disruption in vivo reduces osteoid deposition but not bone quality after voluntary wheel running. [PDF]
PLoS ONEThe Linker of Nucleoskeleton and Cytoskeleton (LINC) complex serves to connect the nuclear envelope and the cytoskeleton, influencing cellular processes such as nuclear arrangement, architecture, and mechanotransduction.
Scott Birks +9 more
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