Results 41 to 50 of about 8,120 (205)
The LINC complex ensures accurate centrosome positioning during prophase
Life Science Alliance, 2023 Abstract Accurate centrosome separation and positioning during early mitosis relies on force- generating mechanisms regulated by a combination of extracellular, cytoplasmic, and nuclear cues. The identity of the nuclear cues involved in this process remains largely unknown.
Lima JT, Pereira AJ, Ferreira JG.
europepmc +3 more sources
Cell Mechanosensitivity Is Enabled by the LINC Nuclear Complex [PDF]
Current Molecular Biology Reports, 2016 Mechanoresponses in mesenchymal stem cells (MSCs) guide both differentiation and function. In this review, we focus on advances in0 our understanding of how the cytoplasmic cytoskeleton, nuclear envelope and nucleoskeleton, which are connected via LINC (Linker of Nucleoskeleton and Cytoskeleton) complexes, are emerging as an integrated dynamic ...
Gunes, Uzer +2 more
openaire +2 more sources
The LINC complex ensures accurate centrosome positioning during prophase. [PDF]
Life Sci AllianceCentrosome positioning in prophase is essential for efficient spindle assembly. Here, we show that centrosome positioning requires LINC complex–mediated loading of dynein on the nuclear envelope.
Lima JT, Pereira AJ, Ferreira JG.
europepmc +2 more sources
Cells, 2020 Cellular senescence, induced by genotoxic or replication stress, is accompanied by defects in nuclear morphology and nuclear membrane-heterochromatin disruption.
Alena Svobodová Kovaříková +3 more
doaj +1 more source
Frontiers in Plant Science, 2014 Following the description of SAD1/UNC84 (SUN) domain proteins in higher plants, evidence has rapidly increased that plants contain a functional Linker of Nucleoskeleton and Cytoskeleton (LINC) complex bridging the nuclear envelope (NE).
David Edgar Evans +3 more
doaj +1 more source
The LINC Complex: A Molecular and Biomechanical Investigation into Breast Cancer Cell Migration [PDF]
, 2022 Cell motility is an important feature during physiological conditions such as in development and wound healing. However, cell migration is also associated with a plethora of debilitating diseases including cancer metastasis.
PAPA, KLEOPATRA
core
Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture
, 2017 [[abstract]]Linker of nucleoskeleton and cytoskeleton (LINC) complexes spanning the nuclear envelope (NE) contribute to nucleocytoskeletal force transduction. A few NE proteins have been found to regulate the LINC complex. In this study, we identify one,
Ding, ZY;Wang, YH;Huang, YC;Lee, MC;Tseng, MJ;Chi, YH;Huang, ML
core +2 more sources
The LINC Between Mechanical Forces and Chromatin
Frontiers in Physiology, 2021 The heart continually senses and responds to mechanical stimuli that balance cardiac structure and activity. Tensile forces, compressive forces, and shear stress are sensed by the different cardiac cell types and converted into signals instructing proper
Olga Lityagina +2 more
doaj +1 more source
Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization. [PDF]
PLoS Genetics, 2014 Proteins of the nuclear envelope (NE) are associated with a range of inherited disorders, most commonly involving muscular dystrophy and cardiomyopathy, as exemplified by Emery-Dreifuss muscular dystrophy (EDMD).
Peter Meinke +10 more
doaj +1 more source
Generation and Analysis of Striated Muscle Selective LINC Complex Protein Mutant Mice [PDF]
, 2018 The linker of nucleoskeleton and cytoskeleton (LINC) complex mediates intracellular cross talk between the nucleus and the cytoplasm. In striated muscle, the LINC complex provides structural support to the myocyte nucleus and plays an essential role in ...
Ju Chen +8 more
core +1 more source