Results 41 to 50 of about 5,180,956 (219)

The LINC complex is essential for hearing [PDF]

Journal of Clinical Investigation, 2013
Hereditary hearing loss is the most common sensory deficit. We determined that progressive high-frequency hearing loss in 2 families of Iraqi Jewish ancestry was due to homozygosity for the protein truncating mutation SYNE4 c.228delAT. SYNE4, a gene not previously associated with hearing loss, encodes nesprin-4 (NESP4), an outer nuclear membrane (ONM ...
Henning F, Horn, Zippora, Brownstein, Danielle R, Lenz, Shaked, Shivatzki, Amiel A, Dror, Orit, Dagan-Rosenfeld, Lilach M, Friedman, Kyle J, Roux, Serguei, Kozlov, Kuan-Teh, Jeang, Moshe, Frydman, Brian, Burke, Colin L, Stewart, Karen B, Avraham   +13 more
openaire   +2 more sources

Differential incorporation of SUN-domain proteins into LINC complexes is coupled to gene expression. [PDF]

PLoS ONE, 2018
LInkers of Nucleoskeleton and Cytoskeleton (LINC) complexes, composed of SUN and KASH-domain proteins, span the nuclear envelope and physically connect the nuclear interior to cytoskeletal elements.
Christopher K May, Christopher W Carroll
doaj   +1 more source

LINC complexes in health and disease [PDF]

Nucleus, 2010
The cell nucleus communicates with the rest of the cell via nucleo/cytoplasmic transport of proteins and RNA through the nuclear pores. Direct mechanical links between the nucleus and the cytoplasm have recently emerged in the form of LINC (Linkers of the nucleoskeleton to the cytoskeleton) protein complexes. A LINC complex consists of four components.
Mejat, Alexandre, Misteli, Tom
openaire   +3 more sources

Structural insights into LINC complexes [PDF]

Current Opinion in Structural Biology, 2013
Communication between nucleus and cytoplasm extends past molecular exchange and critically includes mechanical wiring. Cytoskeleton and nucleoskeleton are connected via molecular tethers that span the nuclear envelope. Sad1, UNC84 (SUN)-domain proteins spanning the inner nuclear membrane and Klarsicht, ANC-1 and SYNE/Nesprin-1 and -2 Homology (KASH ...
Kutay, Ulrike, Schwartz, Thomas, Sosa, Brian A.   +2 more
openaire   +5 more sources

Maize (Zea mays L.) Nucleoskeletal Proteins Regulate Nuclear Envelope Remodeling and Function in Stomatal Complex Development and Pollen Viability

Frontiers in Plant Science, 2021
In eukaryotes, the nuclear envelope (NE) encloses chromatin and separates it from the rest of the cell. The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex physically bridges across the NE, linking nuclear and cytoplasmic components.
Joseph F. McKenna, Hardeep K. Gumber, Zachary M. Turpin, Alexis M. Jalovec, Andre C. Kartick, Katja Graumann, Hank W. Bass   +6 more
doaj   +1 more source

SWR1-Independent Association of H2A.Z to the LINC Complex Promotes Meiotic Chromosome Motion. [PDF]

Front Cell Dev Biol, 2020
González-Arranz S, Gardner JM, Yu Z, Patel NJ, Heldrich J, Santos B, Carballo JA, Jaspersen SL, Hochwagen A, San-Segundo PA.   +9 more
europepmc   +2 more sources

LINCing Senescence and Nuclear Envelope Changes

Cells, 2022
The nuclear envelope (NE) has emerged as a nexus for cellular organization, signaling, and survival. Beyond its role as a barrier to separate the nucleoplasm from the cytoplasm, the NE’s role in supporting and maintaining a myriad of other functions has ...
Bakhita R. M. Meqbel, Matilde Gomes, Amr Omer, Imed E. Gallouzi, Henning F. Horn   +4 more
doaj   +1 more source

Accessorizing and anchoring the LINC complex for multifunctionality [PDF]

Journal of Cell Biology, 2015
The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 (SUN) proteins, respectively, connects the nucleus to cytoskeletal filaments and performs diverse functions including nuclear positioning, mechanotransduction, and meiotic chromosome ...
Chang, Wakam, Worman, Howard J., Gundersen, Gregg G.   +2 more
openaire   +2 more sources

Molecular models of LINC complex assembly at the nuclear envelope [PDF]

Journal of Cell Science, 2021
ABSTRACT Large protein complexes assemble at the nuclear envelope to transmit mechanical signals between the cytoskeleton and nucleoskeleton. These protein complexes are known as the linkers of the nucleoskeleton and cytoskeleton complexes (LINC complexes) and are formed by the interaction of SUN and KASH domain proteins in the nuclear ...
Zeinab Jahed, Nya Domkam, Jessica Ornowski, Ghafar Yerima, Mohammad R. K. Mofrad   +4 more
openaire   +2 more sources

Coupling of the nucleus and cytoplasm: Role of the LINC complex [PDF]

The Journal of Cell Biology, 2005
The nuclear envelope defines the barrier between the nucleus and cytoplasm and features inner and outer membranes separated by a perinuclear space (PNS). The inner nuclear membrane contains specific integral proteins that include Sun1 and Sun2. Although the outer nuclear membrane (ONM) is continuous with the endoplasmic reticulum, it is nevertheless ...
Crisp, M., Liu, Q., Roux, K., Rattner, J. B., Shanahan, C., Burke, B., Stahl, P. D., Hodzic, D.   +7 more
openaire   +4 more sources