Results 41 to 50 of about 7,490 (198)

Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization. [PDF]

PLoS Genetics, 2014
Proteins of the nuclear envelope (NE) are associated with a range of inherited disorders, most commonly involving muscular dystrophy and cardiomyopathy, as exemplified by Emery-Dreifuss muscular dystrophy (EDMD).
Peter Meinke, Elisabetta Mattioli, Farhana Haque, Susumu Antoku, Marta Columbaro, Kees R Straatman, Howard J Worman, Gregg G Gundersen, Giovanna Lattanzi, Manfred Wehnert, Sue Shackleton   +10 more
doaj   +1 more source

Nuclear SUN1 stabilizes endothelial cell junctions via microtubules to regulate blood vessel formation

eLife, 2023
Endothelial cells line all blood vessels, where they coordinate blood vessel formation and the blood-tissue barrier via regulation of cell-cell junctions.
Danielle B Buglak, Pauline Bougaran, Molly R Kulikauskas, Ziqing Liu, Elizabeth Monaghan-Benson, Ariel L Gold, Allison P Marvin, Andrew Burciu, Natalie T Tanke, Morgan Oatley, Shea N Ricketts, Karina Kinghorn, Bryan N Johnson, Celia E Shiau, Stephen Rogers, Christophe Guilluy, Victoria L Bautch   +16 more
doaj   +1 more source

SUN1/2 Are Essential for RhoA/ROCK-Regulated Actomyosin Activity in Isolated Vascular Smooth Muscle Cells

Cells, 2020
Vascular smooth muscle cells (VSMCs) are the predominant cell type in the blood vessel wall. Changes in VSMC actomyosin activity and morphology are prevalent in cardiovascular disease. The actin cytoskeleton actively defines cellular shape and the LInker
Lauren Porter, Rose-Marie Minaisah, Sultan Ahmed, Seema Ali, Rosemary Norton, Qiuping Zhang, Elisa Ferraro, Chris Molenaar, Mark Holt, Susan Cox, Samuel Fountain, Catherine Shanahan, Derek Warren   +12 more
doaj   +1 more source

Birth of a Regulatory Long Non-coding RNA/Gene, linc-UR-UB

Frontiers in Genetics, 2021
The origin of genes has been a major topic of research for many years, albeit in some cases, it has been a difficult process to elucidate. Insightful is a recent publication that experimentally shows how one gene, linc-UR-UB was born.
Nicholas Delihas
doaj   +1 more source

LINC complex alterations in DMD and EDMD/CMT fibroblasts [PDF]

European Journal of Cell Biology, 2012
Emery-Dreifuss muscular dystrophy (EDMD) is a late onset-disease characterized by skeletal muscle wasting and heart defects with associated risk of sudden death. The autosomal dominant form of the disease is caused by mutations in the LMNA gene encoding LaminA and C, the X-linked form results from mutations in the gene encoding the inner nuclear ...
Taranum, Surayya, Vaylann, Eva, Meinke, Peter, Abraham, Sabu; id_orcid 0000-0002-0916-5827, Yang, Liu, Neumann, Sascha, Karakesisoglou, Iakowos, Wehnert, Manfred, Noegel, Angelika A.   +8 more
openaire   +2 more sources

MLKS2 is an ARM domain and F-actin-associated KASH protein that functions in stomatal complex development and meiotic chromosome segregation

Nucleus, 2019
The linker of nucleoskeleton and cytoskeleton (LINC) complex is an essential multi-protein structure spanning the eukaryotic nuclear envelope. The LINC complex functions to maintain nuclear architecture, positioning, and mobility, along with specialized ...
Hardeep K. Gumber, Joseph F. McKenna, Andrea F. Tolmie, Alexis M. Jalovec, Andre C. Kartick, Katja Graumann, Hank W. Bass   +6 more
doaj   +1 more source

The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity

eLife, 2019
Here we show that a major muscle specific isoform of the murine LINC complex protein SUN1 is required for efficient muscle regeneration. The nucleoplasmic domain of the isoform specifically binds to and inhibits Drosha, a key component of the ...
Tsui Han Loo, Xiaoqian Ye, Ruth Jinfen Chai, Mitsuteru Ito, Gisèle Bonne, Anne C Ferguson-Smith, Colin L Stewart   +6 more
doaj   +1 more source

Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD

Nature Communications, 2017
Long non-coding RNAs (lncRNAs) are important regulators of diverse biological processes. Here we report on functional identification and characterization of a novel long intergenic non-coding RNA with MyoD-regulated and skeletal muscle-restricted ...
Xiaohua Yu, Yong Zhang, Tingting Li, Zhao Ma, Haixue Jia, Qian Chen, Yixia Zhao, Lili Zhai, Ran Zhong, Changyin Li, Xiaoting Zou, Jiao Meng, Antony K. Chen, Pier Lorenzo Puri, Meihong Chen, Dahai Zhu   +15 more
doaj   +1 more source

Mechanical Characterization of Glandular Acini Using a Micro-indentation Instrument

Bio-Protocol, 2020
The linker of nucleoskeleton and cytoskeleton (LINC) complex is responsible for tethering the nucleus to the cytoskeleton, providing a pathway for the cell’s nucleus to sense mechanical signals from the environment.
Christopher O'Bryan, Qiao Zhang, Tanmay Lele, Thomas Angelini   +3 more
doaj   +1 more source

Role of KASH domain lengths in the regulation of LINC complexes [PDF]

Molecular Biology of the Cell, 2019
The linker of the nucleoskeleton and cytoskeleton (LINC) complex is formed by the conserved interactions between Sad-1 and UNC-84 (SUN) and Klarsicht, ANC-1, SYNE homology (KASH) domain proteins, providing a physical coupling between the nucleoskeleton and cytoskeleton that mediates the transfer of physical forces across the nuclear envelope.
Jahed, Zeinab, Hao, Hongyan, Thakkar, Vyom, Vu, Uyen T, Valdez, Venecia A, Rathish, Akshay, Tolentino, Chris, Kim, Samuel CJ, Fadavi, Darya, Starr, Daniel A, Mofrad, Mohammad RK   +10 more
openaire   +3 more sources