Results 31 to 40 of about 7,490 (198)
LINCing Senescence and Nuclear Envelope Changes
Cells, 2022 The nuclear envelope (NE) has emerged as a nexus for cellular organization, signaling, and survival. Beyond its role as a barrier to separate the nucleoplasm from the cytoplasm, the NE’s role in supporting and maintaining a myriad of other functions has ...
Bakhita R. M. Meqbel +4 more
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Accessorizing and anchoring the LINC complex for multifunctionality [PDF]
Journal of Cell Biology, 2015 The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of outer and inner nuclear membrane Klarsicht, ANC-1, and Syne homology (KASH) and Sad1 and UNC-84 (SUN) proteins, respectively, connects the nucleus to cytoskeletal filaments and performs diverse functions including nuclear positioning, mechanotransduction, and meiotic chromosome ...
Chang, Wakam +2 more
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The plant LINC complex at the nuclear envelope [PDF]
Chromosome Research, 2014 Significant advances in understanding the plant nuclear envelope have been made over the past few years; indeed, knowledge of the protein network at the nuclear envelope is rapidly growing. One such network, the linker of nucleoskeleton and cytoskeleton (LINC) complex, is known in animals to connect chromatin to the cytoskeleton through the nuclear ...
Tatout, Christophe +4 more
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Coupling of the nucleus and cytoplasm: Role of the LINC complex [PDF]
The Journal of Cell Biology, 2005 The nuclear envelope defines the barrier between the nucleus and cytoplasm and features inner and outer membranes separated by a perinuclear space (PNS). The inner nuclear membrane contains specific integral proteins that include Sun1 and Sun2. Although the outer nuclear membrane (ONM) is continuous with the endoplasmic reticulum, it is nevertheless ...
Crisp, M. +7 more
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LINCing complex functions at the nuclear envelope [PDF]
Nucleus, 2013 Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the double membrane of the nuclear envelope (NE) and physically connect nuclear structures to cytoskeletal elements. LINC complexes are envisioned as force transducers in the NE, which facilitate processes like nuclear anchorage and migration, or chromosome movements.
Rothballer Andrea +2 more
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Molecular models of LINC complex assembly at the nuclear envelope [PDF]
Journal of Cell Science, 2021 ABSTRACT Large protein complexes assemble at the nuclear envelope to transmit mechanical signals between the cytoskeleton and nucleoskeleton. These protein complexes are known as the linkers of the nucleoskeleton and cytoskeleton complexes (LINC complexes) and are formed by the interaction of SUN and KASH domain proteins in the nuclear ...
Zeinab Jahed +4 more
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Cell Mechanosensitivity Is Enabled by the LINC Nuclear Complex [PDF]
Current Molecular Biology Reports, 2016 Mechanoresponses in mesenchymal stem cells (MSCs) guide both differentiation and function. In this review, we focus on advances in0 our understanding of how the cytoplasmic cytoskeleton, nuclear envelope and nucleoskeleton, which are connected via LINC (Linker of Nucleoskeleton and Cytoskeleton) complexes, are emerging as an integrated dynamic ...
Gunes, Uzer +2 more
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Cells, 2020 Cellular senescence, induced by genotoxic or replication stress, is accompanied by defects in nuclear morphology and nuclear membrane-heterochromatin disruption.
Alena Svobodová Kovaříková +3 more
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Frontiers in Plant Science, 2014 Following the description of SAD1/UNC84 (SUN) domain proteins in higher plants, evidence has rapidly increased that plants contain a functional Linker of Nucleoskeleton and Cytoskeleton (LINC) complex bridging the nuclear envelope (NE).
David Edgar Evans +3 more
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The LINC Between Mechanical Forces and Chromatin
Frontiers in Physiology, 2021 The heart continually senses and responds to mechanical stimuli that balance cardiac structure and activity. Tensile forces, compressive forces, and shear stress are sensed by the different cardiac cell types and converted into signals instructing proper
Olga Lityagina +2 more
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