Nuclei on the move: LINC complex-dependent and -independent mechanisms of nuclear migration in development [PDF]
NucleusNuclear positioning drives developmental processes from fertilization to neurogenesis. The linker of nucleoskeleton and cytoskeleton (LINC) complex connects nuclei to cytoskeletal force generators that power nuclear migration.
Selin Gümüşderelioğlu +2 more
doaj +2 more sources
The LINC complex, mechanotransduction, and mesenchymal stem cell function and fate [PDF]
Journal of Biological Engineering, 2019 Mesenchymal stem cells (MSCs) show tremendous promise as a cell source for tissue engineering and regenerative medicine, and are understood to be mechanosensitive to external mechanical environments. In recent years, increasing evidence points to nuclear
Tasneem Bouzid +7 more
doaj +2 more sources
The LINC complex ensures accurate centrosome positioning during prophase [PDF]
Life Science AllianceCentrosome positioning in prophase is essential for efficient spindle assembly. Here, we show that centrosome positioning requires LINC complex–mediated loading of dynein on the nuclear envelope.
Joana T Lima +2 more
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The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity [PDF]
eLife, 2019 Here we show that a major muscle specific isoform of the murine LINC complex protein SUN1 is required for efficient muscle regeneration. The nucleoplasmic domain of the isoform specifically binds to and inhibits Drosha, a key component of the ...
Tsui Han Loo +6 more
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The LINC Complex: A Molecular and Biomechanical Investigation into Breast Cancer Cell Migration [PDF]
, 2022 Cell motility is an important feature during physiological conditions such as in development and wound healing. However, cell migration is also associated with a plethora of debilitating diseases including cancer metastasis.
Papa, Kleopatra
core +6 more sources
Nucleus, 2020 Nuclear movement and positioning play a role in developmental processes throughout life. Nuclear movement and positioning are mediated primarily by linker of nucleoskeleton and cytoskeleton (LINC) complexes.
Morgan Moser +3 more
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Building and breaking mechanical bridges between the nucleus and cytoskeleton: Regulation of LINC complex assembly and disassembly. [PDF]
Curr Opin Cell Biol, 2023 The nucleus is physically coupled to the cytoskeleton through LINC complexes, macromolecular bridges composed of SUN and KASH proteins that span the nuclear envelope. LINC complexes are involved in a wide variety of critical cellular processes. For these
McGillivary RM, Starr DA, Luxton GWG.
europepmc +2 more sources
Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics. [PDF]
Proc Natl Acad Sci U S A, 2022 Vahabikashi A +15 more
europepmc +2 more sources
Disulfide bond in SUN2 regulates dynamic remodeling of LINC complexes at the nuclear envelope
Life Science Alliance, 2023 The LINC complex tethers the cell nucleus to the cytoskeleton to regulate mechanical forces during cell migration, differentiation, and various diseases.
Rahul Sharma, Martin W Hetzer
doaj +1 more source
Molecular tension microscopy of the LINC complex in live cells. [PDF]
STAR Protoc, 2022 We present a protocol to measure the effect of pharmacological treatments on the mechanical tension experienced by nesprins at the cytoplasmic surface of the nuclear envelope of mammalian cells in culture. We apply this protocol to MDCK epithelial cells exposed to the actin depolymerization agent cytochalasin D.
Sipieter F +3 more
europepmc +5 more sources