Results 31 to 40 of about 8,120 (205)

Structural insights into LINC complexes [PDF]

Current Opinion in Structural Biology, 2013
Communication between nucleus and cytoplasm extends past molecular exchange and critically includes mechanical wiring. Cytoskeleton and nucleoskeleton are connected via molecular tethers that span the nuclear envelope. Sad1, UNC84 (SUN)-domain proteins spanning the inner nuclear membrane and Klarsicht, ANC-1 and SYNE/Nesprin-1 and -2 Homology (KASH ...
Kutay, Ulrike, Schwartz, Thomas, Sosa, Brian A.   +2 more
openaire   +5 more sources

Maize (Zea mays L.) Nucleoskeletal Proteins Regulate Nuclear Envelope Remodeling and Function in Stomatal Complex Development and Pollen Viability

Frontiers in Plant Science, 2021
In eukaryotes, the nuclear envelope (NE) encloses chromatin and separates it from the rest of the cell. The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex physically bridges across the NE, linking nuclear and cytoplasmic components.
Joseph F. McKenna, Hardeep K. Gumber, Zachary M. Turpin, Alexis M. Jalovec, Andre C. Kartick, Katja Graumann, Hank W. Bass   +6 more
doaj   +1 more source

Prrx1-driven LINC complex disruption in vivo reduces osteoid deposition but not bone quality after voluntary wheel running. [PDF]

PLoS One
The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex serves to connect the nuclear envelope and the cytoskeleton, influencing cellular processes such as nuclear arrangement, architecture, and mechanotransduction.
Birks S, Howard S, Wright CS, O'Rourke C, Day EA, Lamb AJ, Walsdorf JR, Lau A, Thompson WR, Uzer G.   +9 more
europepmc   +2 more sources

Inhibition of PDIs Downregulates Core LINC Complex Proteins, Promoting the Invasiveness of MDA-MB-231 Breast Cancer Cells in Confined Spaces In Vitro. [PDF]

Cells
Eukaryotic cells tether the nucleoskeleton to the cytoskeleton via a conserved molecular bridge, called the LINC complex. The core of the LINC complex comprises SUN-domain and KASH-domain proteins that directly associate within the nuclear envelope lumen.
Young N, Gui Z, Mustafa S, Papa K, Jessop E, Ruddell E, Bevington L, Quinlan RA, Benham AM, Goldberg MW, Obara B, Karakesisoglou I.   +11 more
europepmc   +2 more sources

LINCing Senescence and Nuclear Envelope Changes

Cells, 2022
The nuclear envelope (NE) has emerged as a nexus for cellular organization, signaling, and survival. Beyond its role as a barrier to separate the nucleoplasm from the cytoplasm, the NE’s role in supporting and maintaining a myriad of other functions has ...
Bakhita R. M. Meqbel, Matilde Gomes, Amr Omer, Imed E. Gallouzi, Henning F. Horn   +4 more
doaj   +1 more source

Molecular models of LINC complex assembly at the nuclear envelope [PDF]

Journal of Cell Science, 2021
ABSTRACT Large protein complexes assemble at the nuclear envelope to transmit mechanical signals between the cytoskeleton and nucleoskeleton. These protein complexes are known as the linkers of the nucleoskeleton and cytoskeleton complexes (LINC complexes) and are formed by the interaction of SUN and KASH domain proteins in the nuclear ...
Zeinab Jahed, Nya Domkam, Jessica Ornowski, Ghafar Yerima, Mohammad R. K. Mofrad   +4 more
openaire   +2 more sources

The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation. [PDF]

Elife, 2021
While the mechanisms by which chemical signals control cell fate have been well studied, the impact of mechanical inputs on cell fate decisions is not well understood.
Carley E, Stewart RM, Zieman A, Jalilian I, King DE, Zubek A, Lin S, Horsley V, King MC.   +8 more
europepmc   +2 more sources

Nuclei on the move: LINC complex-dependent and -independent mechanisms of nuclear migration in development. [PDF]

Nucleus
Nuclear positioning drives developmental processes from fertilization to neurogenesis. The linker of nucleoskeleton and cytoskeleton (LINC) complex connects nuclei to cytoskeletal force generators that power nuclear migration.
Gümüşderelioğlu S, Gant Luxton GW, Starr DA.   +2 more
europepmc   +2 more sources

Coupling of the nucleus and cytoplasm: Role of the LINC complex [PDF]

The Journal of Cell Biology, 2005
The nuclear envelope defines the barrier between the nucleus and cytoplasm and features inner and outer membranes separated by a perinuclear space (PNS). The inner nuclear membrane contains specific integral proteins that include Sun1 and Sun2. Although the outer nuclear membrane (ONM) is continuous with the endoplasmic reticulum, it is nevertheless ...
Crisp, M., Liu, Q., Roux, K., Rattner, J. B., Shanahan, C., Burke, B., Stahl, P. D., Hodzic, D.   +7 more
openaire   +4 more sources

LINCing complex functions at the nuclear envelope [PDF]

Nucleus, 2013
Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the double membrane of the nuclear envelope (NE) and physically connect nuclear structures to cytoskeletal elements. LINC complexes are envisioned as force transducers in the NE, which facilitate processes like nuclear anchorage and migration, or chromosome movements.
Rothballer Andrea, Schwartz Thomas U., Kutay Ulrike   +2 more
openaire   +5 more sources