Results 51 to 60 of about 5,180,956 (219)
LINCing complex functions at the nuclear envelope [PDF]
Nucleus, 2013 Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the double membrane of the nuclear envelope (NE) and physically connect nuclear structures to cytoskeletal elements. LINC complexes are envisioned as force transducers in the NE, which facilitate processes like nuclear anchorage and migration, or chromosome movements.
Rothballer Andrea +2 more
openaire +5 more sources
Cells, 2020 Cellular senescence, induced by genotoxic or replication stress, is accompanied by defects in nuclear morphology and nuclear membrane-heterochromatin disruption.
Alena Svobodová Kovaříková +3 more
doaj +1 more source
Frontiers in Plant Science, 2014 Following the description of SAD1/UNC84 (SUN) domain proteins in higher plants, evidence has rapidly increased that plants contain a functional Linker of Nucleoskeleton and Cytoskeleton (LINC) complex bridging the nuclear envelope (NE).
David Edgar Evans +3 more
doaj +1 more source
Cell Mechanosensitivity Is Enabled by the LINC Nuclear Complex [PDF]
Current Molecular Biology Reports, 2016 Mechanoresponses in mesenchymal stem cells (MSCs) guide both differentiation and function. In this review, we focus on advances in0 our understanding of how the cytoplasmic cytoskeleton, nuclear envelope and nucleoskeleton, which are connected via LINC (Linker of Nucleoskeleton and Cytoskeleton) complexes, are emerging as an integrated dynamic ...
Gunes, Uzer +2 more
openaire +2 more sources
Functional characterization of LINC complex protein assemblies and their role in laminopathies [PDF]
, 2013 LINC (Linker of nucleoskeleton and cytoskeleton) complexes connect the nucleoskeleton to the cytoskeleton by interactions among LINC complex proteins and their interactions to proteins in the nucleus and the cytosol.
Yang, Liu
core +1 more source
The LINC Between Mechanical Forces and Chromatin
Frontiers in Physiology, 2021 The heart continually senses and responds to mechanical stimuli that balance cardiac structure and activity. Tensile forces, compressive forces, and shear stress are sensed by the different cardiac cell types and converted into signals instructing proper
Olga Lityagina +2 more
doaj +1 more source
Muscular dystrophy-associated SUN1 and SUN2 variants disrupt nuclear-cytoskeletal connections and myonuclear organization. [PDF]
PLoS Genetics, 2014 Proteins of the nuclear envelope (NE) are associated with a range of inherited disorders, most commonly involving muscular dystrophy and cardiomyopathy, as exemplified by Emery-Dreifuss muscular dystrophy (EDMD).
Peter Meinke +10 more
doaj +1 more source
Outer nuclear membrane protein Kuduk modulates the LINC complex and nuclear envelope architecture
, 2017 Linker of nucleoskeleton and cytoskeleton (LINC) complexes spanning the nuclear envelope (NE) contribute to nucleocytoskeletal force transduction. A few NE proteins have been found to regulate the LINC complex. In this study, we identify one, Kuduk (Kud),
Ya-Hui Chi +6 more
core +2 more sources
eLife, 2023 Endothelial cells line all blood vessels, where they coordinate blood vessel formation and the blood-tissue barrier via regulation of cell-cell junctions.
Danielle B Buglak +16 more
doaj +1 more source
Cells, 2020 Vascular smooth muscle cells (VSMCs) are the predominant cell type in the blood vessel wall. Changes in VSMC actomyosin activity and morphology are prevalent in cardiovascular disease. The actin cytoskeleton actively defines cellular shape and the LInker
Lauren Porter +12 more
doaj +1 more source