Results 71 to 80 of about 8,120 (205)

ECM‐Stiffness Mediated Persistent Fibroblast Activation Requires Integrin and Formin Dependent Chromatin Remodeling

Advanced Science, EarlyView.
Prolonged exposure to stiff extracellular matrix drives cancer‐associated fibroblasts into a persistently activated myofibroblast state. Two parallel pathways are identified: β1 integrin activation smoothens the nuclear lamina to reduce lamin–chromatin contacts, while the formin mDia2 regulates nuclear actin to alter chromatin organization.
Swathi Packirisamy, Oscar André, Zhimeng Fan, Pontus Nordenfelt, Vinay S Swaminathan   +4 more
wiley   +1 more source

Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication. [PDF]

Development, 2020
DNA endoreplication has been implicated as a cell strategy to grow in size and in tissue injury. Here, we demonstrate that barrier to autointegration factor (BAF), represses endoreplication in Drosophila myofibers. We show that BAF localization at the nuclear envelope was eliminated either in mutants of the Linker of Nucleoskeleton and Cytoskeleton ...
Unnikannan CP, Reuveny A, Grunberg D, Volk T.   +3 more
europepmc   +3 more sources

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Sad1 Spatiotemporally Regulates Kinetochore Clustering To Ensure High-Fidelity Chromosome Segregation in the Human Fungal Pathogen Cryptococcus neoformans

mSphere, 2018
Kinetochore clustering, frequently observed in yeasts, plays a key role in genome organization and chromosome segregation. In the absence of the metaphase plate arrangement, kinetochore clustering in yeast species is believed to facilitate timely ...
Vikas Yadav, Kaustuv Sanyal
doaj   +1 more source

A synthetic biology platform for the reconstitution and mechanistic dissection of LINC complex assembly [PDF]

, 2019
The linker of nucleoskeleton and cytoskeleton (LINC) is a conserved nuclear envelope-spanning molecular bridge that is responsible for the mechanical integration of the nucleus with the cytoskeleton.
Willey, Patrick T, DeNies, Maxwell S, Luxton, GW Gant, Majumder, Sagardip, Liu, Allen P   +4 more
core   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Nesprin proteins: bridging nuclear envelope dynamics to muscular dysfunction

Cell Communication and Signaling
This review presents a comprehensive exploration of the pivotal role played by the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, with a particular focus on Nesprin proteins, in cellular mechanics and the pathogenesis of muscular diseases ...
Zhou Zi-yi, Qin Qin, Zhou Fei, Cao Cun-Yu, Teng Lin   +4 more
doaj   +1 more source

The role of LINC complex in male germinal cells

, 2020
LINC (linker of the nucleoskeleton and cytoskeleton) complex is substantial for the overall function of any nuclear cell. It is a bridge between the cytoplasmic and nuclear structures which mediates transmission of mechanical forces generated on the ...
Kmoníčková, Věra
core  

Critical tipping point distinguishing two types of transitions in modular network structures

, 2015
S.S. thanks the James S. McDonnell Foundation 21st Century Science Initiative— Complex Systems Scholar Award (Grant No. 220020315) and the Scottish Informatics and Computer Science Alliance for financial support.Modularity is a key organizing principle ...
Kennett, Dror, Kenett, Dror Y., Dobson, Simon Andrew, Havlin, Shlomo, Faust, Miriam, Kenett, Yoed N., Shai, Saray, Dobson, Simon, Kennett, Yoed   +8 more
core   +1 more source