Results 1 to 10 of about 3,007 (176)
Nesprin-2 Interacts with Condensin Component SMC2 [PDF]
International Journal of Cell Biology, 2017 The nuclear envelope proteins, Nesprins, have been primarily studied during interphase where they function in maintaining nuclear shape, size, and positioning. We analyze here the function of Nesprin-2 in chromatin interactions in interphase and dividing
Xin Xing +10 more
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Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders.
PLoS Genetics, 2023 Bicaudal D2 (BICD2) is responsible for recruiting cytoplasmic dynein to diverse forms of subcellular cargo for their intracellular transport. Mutations in the human BICD2 gene have been found to cause an autosomal dominant form of spinal muscular atrophy
Julie Yi +5 more
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FHODs: Nuclear tethered formins for nuclear mechanotransduction
Frontiers in Cell and Developmental Biology, 2023 In this review, we discuss FHOD formins with a focus on recent studies that reveal a new role for them as critical links for nuclear mechanotransduction. The FHOD family in vertebrates comprises two structurally related proteins, FHOD1 and FHOD3.
Susumu Antoku +2 more
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A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies
eLife, 2021 The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex mechanically couples cytoskeletal and nuclear components across the nuclear envelope to fulfil a myriad of cellular functions, including nuclear shape and positioning, hearing, and meiotic ...
Manickam Gurusaran, Owen Richard Davies
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PLoS Pathogens, 2022 Nuclear entry represents the final and decisive infection step for most DNA viruses, although how this is accomplished by some viruses is unclear. Polyomavirus SV40 transports from the cell surface through the endosome, the endoplasmic reticulum, and the
Chelsey C Spriggs +3 more
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Specialized Positioning of Myonuclei Near Cell-Cell Junctions
Frontiers in Physiology, 2018 Skeletal muscles are large cells with multiple nuclei that are precisely positioned. The importance of the correct nuclear position is highlighted by the correlation between mispositioned nuclei and muscle disease (Spiro et al., 1966; Gueneau et al ...
Margherita Perillo, Eric S. Folker
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eLife, 2021 Non-centrosomal microtubule-organizing centers (MTOCs) are pivotal for the function of multiple cell types, but the processes initiating their formation are unknown. Here, we find that the transcription factor myogenin is required in murine myoblasts for
Robert Becker +7 more
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Frontiers in Immunology, 2022 Upon interaction with immobilized antigens, B cells form an immune synapse where actin remodeling and re-positioning of the microtubule-organizing center (MTOC) together with lysosomes can facilitate antigen extraction.
Romina Ulloa +12 more
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Frontiers in Genetics, 2022 Autosomal recessive cerebellar ataxia type 1 (ARCA-1), also known as autosomal recessive spinocerebellar ataxia type 8 (SCAR8), is caused by spectrin repeat containing nuclear envelope protein 1 (SYNE1) gene mutation.
Nannan Qian +11 more
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Lack of a Retinal Phenotype in a Syne-2/Nesprin-2 Knockout Mouse Model
Cells, 2019 Syne-2 (also known as Nesprin-2) is a member of a family of proteins that are found primarily in the outer nuclear membrane, as well as other subcellular compartments.
Nathalie Falk +7 more
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