Results 11 to 20 of about 3,007 (176)
The Role of Nesprin-4 in Breast Cancer Migration and Invasion [PDF]
CellsCancer metastasis is responsible for most cancer-related deaths. Migration and invasion, key steps in the metastatic cascade, require nuclear pliability to traverse the physical barriers of the extracellular matrix and cell–cell junctions.
Hend Salah Fayed +2 more
exaly +6 more sources
PLoS ONE, 2012 BackgroundNesprins (Nuclear envelope spectrin-repeat proteins) are a novel family of giant spectrin-repeat containing proteins. The nesprin-1 and nesprin-2 genes consist of 146 and 116 exons which encode proteins of ∼1mDa and ∼800 kDa is size ...
Dipen Rajgor +4 more
doaj +5 more sources
Identification and Validation of Putative Nesprin Variants [PDF]
, 2016 Nesprins are a family of multi-isomeric scaffolding proteins that were originally identified at the nuclear envelope (NE), where they bind to lamin A/C, emerin, and SUN-domain containing proteins, to form the LInker of Nucleoskeleton-and-Cytoskeleton ...
Autore, Flavia +2 more
core +16 more sources
The dual guardians of cellular stability: exploring nesprin and lamin in senescence [PDF]
Cell Death and DiseaseCellular senescence is a state where cells permanently exit the cell cycle after a finite number of divisions, while maintaining metabolic activity. This phenomenon, initially described by Leonard Hayflick, plays a pivotal role in aging, contributing to ...
Zi-yi Zhou +5 more
doaj +5 more sources
Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration [PDF]
Cytoskeleton, 2014 Nesprins are large multi-domain proteins that link the nuclear envelope to the cytoskeleton and nucleoskeleton. Here we show that nesprin-1 and nesprin-2 play important roles in regulating cell shape and migration in endothelial cells.
Holt, Ian +6 more
core +4 more sources
SV40 exploits the Nesprin-2-SUN1-KPNA4 axis for stepwise targeting and entry into the host nucleus to promote infection. [PDF]
PLoS PathogensMany DNA viruses including polyomaviruses (PyVs) enter the host nucleus to cause infection, although how this is accomplished is unclear. To infect cells, the prototype PyV SV40 targets to the Nesprin-2 outer nuclear membrane protein and enters the ...
Luke Gohmann, Billy Tsai
doaj +2 more sources
Cytoskeletal Interactions at the Nuclear Envelope Mediated by Nesprins [PDF]
International Journal of Cell Biology, 2012 Nesprin-1 is a giant tail-anchored nuclear envelope protein composed of an N-terminal F-actin binding domain, a long linker region formed by multiple spectrin repeats and a C-terminal transmembrane domain. Based on this structure, it connects the nucleus
Surayya Taranum +8 more
doaj +5 more sources
A Nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells
Frontiers in Cell and Developmental Biology, 2022 Nuclear positioning is important for the functionality of many cell types and is mediated by interactions of cytoskeletal elements and nucleoskeleton proteins.
Daniel A. Starr +2 more
exaly +3 more sources
Drosophila Nesprin-1 Isoforms Differentially Contribute to Muscle Function [PDF]
Cells, 2021 Nesprin-1 is a large scaffold protein connecting nuclei to the actin cytoskeleton via its KASH and Calponin Homology domains, respectively. Nesprin-1 disconnection from nuclei results in altered muscle function and myonuclei mispositioning.
Alexandre Rey +3 more
doaj +4 more sources
Nesprins: tissue-specific expression of epsilon and other short isoforms. [PDF]
PLoS ONE, 2014 Nesprin-1-giant and nesprin-2-giant regulate nuclear positioning by the interaction of their C-terminal KASH domains with nuclear membrane SUN proteins and their N-terminal calponin-homology domains with cytoskeletal actin.
Nguyen Thuy Duong +6 more
doaj +5 more sources