Drosophila Nesprin-1 Isoforms Differentially Contribute to Muscle Function [PDF]
Cells, 2021 Nesprin-1 is a large scaffold protein connecting nuclei to the actin cytoskeleton via its KASH and Calponin Homology domains, respectively. Nesprin-1 disconnection from nuclei results in altered muscle function and myonuclei mispositioning.
Alexandre Rey +3 more
doaj +2 more sources
The ANC-1 (Nesprin-1/2) organelle-anchoring protein functions through mitochondria to polarize axon growth in response to SLT-1. [PDF]
PLoS Genetics, 2022 A family of giant KASH proteins, including C. elegans ANC-1 and mammalian Nesprin-1 and -2, are involved in organelle anchoring and are associated with multiple neurodevelopmental disorders including autism, bipolar disorder, and schizophrenia.
Nathan C Fischer +6 more
doaj +2 more sources
The Nesprin-1/-2 ortholog ANC-1 regulates organelle positioning in C. elegans independently from its KASH or actin-binding domains [PDF]
eLife, 2021 KASH proteins in the outer nuclear membrane comprise the cytoplasmic half of linker of nucleoskeleton and cytoskeleton (LINC) complexes that connect nuclei to the cytoskeleton.
Hongyan Hao +6 more
doaj +2 more sources
A Nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells
Frontiers in Cell and Developmental Biology, 2022 Nuclear positioning is important for the functionality of many cell types and is mediated by interactions of cytoskeletal elements and nucleoskeleton proteins.
Daniel A. Starr +2 more
exaly +3 more sources
The role of SYNE1/2 variants as a potential predisposition factor for the onset of endometriosis [PDF]
Frontiers in ImmunologyEndometriosis (EM) is a chronic, inflammatory gynaecological disorder defined by the presence of endometrial-like tissue outside the uterine cavity, most frequently affecting the ovaries, peritoneum, and uterosacral ligaments.
Aurora Santin +19 more
doaj +2 more sources
CCDC141 is a Connectin/Titin and Nesprin-1 binding protein that adapts cardiomyocytes to mechanical stress [PDF]
Communications BiologyThe heart adapts to mechanical stresses such as hypertension, yet the underlying mechanisms remain poorly understood. We identify CCDC141 as a mechanoadaptive factor in cardiomyocytes. CCDC141 interacts with the sarcomeric connectin/titin filament system
Akira Hanashima +14 more
doaj +2 more sources
Lamins and nesprin-1 mediate inside-out mechanical coupling in muscle cell precursors through FHOD1 [PDF]
Scientific Reports, 2017 LINC complexes are crucial for the response of muscle cell precursors to the rigidity of their environment, but the mechanisms explaining this behaviour are not known. Here we show that pathogenic mutations in LMNA or SYNE-1 responsible for severe muscle
Christine Schwartz +12 more
doaj +2 more sources
Nesprins: tissue-specific expression of epsilon and other short isoforms. [PDF]
PLoS ONE, 2014 Nesprin-1-giant and nesprin-2-giant regulate nuclear positioning by the interaction of their C-terminal KASH domains with nuclear membrane SUN proteins and their N-terminal calponin-homology domains with cytoskeletal actin.
Nguyen Thuy Duong +6 more
doaj +1 more source
Nesprin-1 role in DNA damage response [PDF]
Nucleus, 2014 Angelika A. Noegel, Sascha Neumann
exaly +2 more sources
A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies
eLife, 2021 The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex mechanically couples cytoskeletal and nuclear components across the nuclear envelope to fulfil a myriad of cellular functions, including nuclear shape and positioning, hearing, and meiotic ...
Manickam Gurusaran, Owen Richard Davies
doaj +1 more source