Results 41 to 50 of about 3,007 (176)

Putting organelles in their place

eLife, 2021
Experiments in C. elegans reveal new insights into how the ANC-1 protein helps to anchor the nucleus and other organelles in place.
Patricia Ulm, Verena Jantsch
doaj   +1 more source

Nesprin 1 is critical for nuclear positioning and anchorage [PDF]

Human Molecular Genetics, 2009
Nesprin 1 is an outer nuclear membrane protein that is thought to link the nucleus to the actin cytoskeleton. Recent data suggest that mutations in Nesprin 1 may also be involved in the pathogenesis of Emery-Dreifuss muscular dystrophy. To investigate the function of Nesprin 1 in vivo, we generated a mouse model in which all isoforms of Nesprin 1 ...
Zhang, Jianlin, Felder, Amanda, Liu, Yujie, Guo, Ling T., Lange, Stephan, Dalton, Nancy D., Gu, Yusu, Peterson, Kirk L., Mizisin, Andrew P., Shelton, G. Diane, Lieber, Richard L., Chen, Ju   +11 more
openaire   +2 more sources

The Nesprin family member ANC-1 regulates synapse formation and axon termination by functioning in a pathway with RPM-1 and β-Catenin. [PDF]

PLoS Genetics, 2014
Mutations in Nesprin-1 and 2 (also called Syne-1 and 2) are associated with numerous diseases including autism, cerebellar ataxia, cancer, and Emery-Dreifuss muscular dystrophy.
Erik D Tulgren, Shane M Turgeon, Karla J Opperman, Brock Grill   +3 more
doaj   +1 more source

The Nemp1-Nesprin complex mediates cellular responses to matrix mechanics. [PDF]

Proc Natl Acad Sci U S A
Nuclear Envelope Membrane Protein 1 (NEMP1) is crucial for metazoan fertility; loss of Nemp1 causes death of primordial oocytes that reside in the mechanically challenging ovarian cortex. Here, we show that softening the ovary rescues oocyte loss and restores fertility in N emp1
Ganguly A, Zmuda H, Abello J, Illy D, Walter C, Tsatskis Y, Thanintorn N, Zhang Y, Hakim BA, Hodzic D, Stratman AN, Jurisicova A, Pathak A, McNeill H.   +13 more
europepmc   +4 more sources

Nesprins are mechanotransducers that discriminate epithelial–mesenchymal transition programs

Journal of Cell Biology, 2020
LINC complexes are transmembrane protein assemblies that physically connect the nucleoskeleton and cytoskeleton through the nuclear envelope. Dysfunctions of LINC complexes are associated with pathologies such as cancer and muscular disorders. The mechanical roles of LINC complexes are poorly understood.
Théophile Déjardin, Pietro Salvatore Carollo, François Sipieter, Patricia M. Davidson, Cynthia Seiler, Damien Cuvelier, Bruno Cadot, Cecile Sykes, Edgar R. Gomes, Nicolas Borghi   +9 more
openaire   +4 more sources

Nesprins and Lamins in Health and Diseases of Cardiac and Skeletal Muscles [PDF]

Frontiers in Physiology, 2018
Since the discovery of the inner nuclear transmembrane protein emerin in the early 1990s, nuclear envelope (NE) components and related involvement in nuclei integrity and functionality have been highly investigated. The NE is composed of two distinct lipid bilayers described as the inner (INM) and outer (ONM) nuclear membrane.
Alexandre Janin, Alexandre Janin, Vincent Gache   +2 more
openaire   +3 more sources

The nesprin–IF connection

The Journal of Cell Biology, 2005
![Graphic][1] Nesprin-3 (green) recruits plectin (red) to the nuclear perimeter, where it connects to keratins (blue).The nucleus is linked to the cytoplasmic intermediate filament (IF) network, say Wilhelmsen et al.
openaire   +2 more sources

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

Advanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia, Giulia E. M. Ammirati, Sophie Herzog, Tommy Krug, Nico Strohmeyer, Miguel Camacho Rufino, Matthias P. Lutolf, David A. Weitz, Daniel J. Müller   +8 more
wiley   +1 more source

Protocol for Reconstituting Adaptor‐Mediated Activation of Full‐Length Kinesin‐1

Cytoskeleton, EarlyView.
ABSTRACT Kinesin‐1 is a member of the kinesin superfamily that plays an essential role in intracellular cargo transport. In the absence of cargo, Kinesin‐1 exhibits low motor activity due to autoinhibition. Multiple studies have demonstrated that adaptor proteins, which link cargos to Kinesin‐1, can activate Kinesin‐1 by releasing the autoinhibition ...
Haruka Masumoto, Kyoko Chiba
wiley   +1 more source