Results 21 to 30 of about 3,007 (176)

The role of SYNE1/2 variants as a potential predisposition factor for the onset of endometriosis [PDF]

Frontiers in Immunology
Endometriosis (EM) is a chronic, inflammatory gynaecological disorder defined by the presence of endometrial-like tissue outside the uterine cavity, most frequently affecting the ovaries, peritoneum, and uterosacral ligaments.
Aurora Santin, Silvia Pegoraro, Miriam Toffoli, Giulia Pianigiani, Andrea Balduit, Gabriella Zito, Alessandro Mangogna, Alessandro Mangogna, Paola Trevisiol, Lara Emily Rosso, Federica Mannino, Giovanni Di Lorenzo, Francesca Rossi, Eva Andreuzzi, Chiara Agostinis, Giuseppe Ricci, Giuseppe Ricci, Roberta Bulla, Giorgia Girotto, Giorgia Girotto   +19 more
doaj   +2 more sources

Mouse models of nesprin-related diseases [PDF]

Biochemical Society Transactions, 2018
Nesprins (nuclear envelope spectrin repeat proteins) are a family of multi-isomeric scaffolding proteins. Nesprins form the LInker of Nucleoskeleton-and-Cytoskeleton (LINC) complex with SUN (Sad1p/UNC84) domain-containing proteins at the nuclear envelope,
Derek T. Warren, Rao, Li, Catherine M. Shanahan, Shanahan, Catherine M, Qiuping Zhang, Zhou, Can, Zhang, Qiuping, Can Zhou, Li Rao, Warren, Derek T   +9 more
core   +5 more sources

Apoptosis-induced translocation of nesprin-2 from the nuclear envelope to mitochondria is associated with mitochondrial dysfunction

Nucleus
Accumulating evidence suggests that the nuclear envelope (NE) is not just a target, but also a mediator of apoptosis. We showed recently that the NE protein nesprin-2 has pro-apoptotic activity, which involves its subcellular redistribution and Bcl-2 ...
Cecilia Östlund, Reuven Stein, Gregg G Gundersen   +2 more
exaly   +3 more sources

Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.

PLoS Genetics, 2014
Recent interest has focused on the importance of the nucleus and associated nucleoskeleton in regulating changes in cardiac gene expression in response to biomechanical load.
Indroneal Banerjee, Jianlin Zhang, Thomas Moore-Morris, Emily Pfeiffer, Kyle S Buchholz, Ao Liu, Kunfu Ouyang, Matthew J Stroud, Larry Gerace, Sylvia M Evans, Andrew McCulloch, Ju Chen   +11 more
doaj   +5 more sources

Elevated SUN1 promotes migratory cell polarity defects through mechanically coupling microtubules to the nuclear lamina [PDF]

Communications Biology
In migratory fibroblasts, front-rear polarity is defined by the centrosome positioned anterior to a rearward nucleus. To achieve this polarity, actin cables couple to nuclear membrane proteins nesprin-2G and SUN2 and drive the nucleus backward.
Yutao Li, Yicong Zhang, Mengqi Chen, Susumu Antoku, Junjun Ding, Kaiyao Huang, Gregg G. Gundersen, Wakam Chang   +7 more
doaj   +2 more sources

Detection of Diverse and High Molecular Weight Nesprin-1 and Nesprin-2 Isoforms Using Western Blotting

, 2016
Heavily utilized in cell and molecular biology, western blotting is considered a crucial technique for the detection and quantification of proteins within complex mixtures. In particular, the detection of members of the nesprin (nuclear envelope spectrin
Iakowos Karakesisoglou, Karakesisoglou, Iakowos, Carthew, James, James Carthew   +3 more
core   +3 more sources

Tension-sensitive LINC-RhoA signaling prevents chromatin bridge breakage in cytokinesis [PDF]

The EMBO Journal
In the presence of chromatin bridges in cytokinesis, human cells retain actin-rich structures (actin patches) at the base of the intercellular canal to prevent chromosome breakage.
Sofia Balafouti, Maria Kabouraki, George Zachos, Eleni Petsalaki   +3 more
doaj   +2 more sources

Vimentin molecular linkages with nesprin-3 enhance nuclear deformations by cell geometric constraints [PDF]

Scientific Reports
The nucleus is the organelle of the cell responsible for controlling protein expression, which has a direct effect on cellular biological functions. Here we show that the cytoskeletal protein vimentin plays an important role in increasing the amount of ...
Maxx Swoger, Minh Tri Ho Thanh, Renita Saldanha, Fitzroy J. Byfield, Van Dam, Jessica Williamson, Bronson Frank, Heidi Hehnly, Daniel Conway, Alison E. Patteson   +9 more
doaj   +2 more sources

Nesprin proteins: bridging nuclear envelope dynamics to muscular dysfunction

Cell Communication and Signaling
This review presents a comprehensive exploration of the pivotal role played by the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, with a particular focus on Nesprin proteins, in cellular mechanics and the pathogenesis of muscular diseases ...
Zhou Zi-yi, Qin Qin, Zhou Fei, Cao Cun-Yu, Teng Lin   +4 more
doaj   +3 more sources

Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton. [PDF]

, 2009
Meckel-Gruber syndrome (MKS) is a severe autosomal recessively inherited disorder caused by mutations in genes that encode components of the primary cilium and basal body.
HR Dawe (21822902), CV Logan (16122116), K Gull (16190003), G Wheway (21822905), M Adams (8473872), AA Noegel (21822911), CA Johnson (7770536), K Szymanska (21822908)   +7 more
core   +6 more sources