Results 31 to 40 of about 3,007 (176)

Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.

, 2017
The nucleus is the main microtubule-organizing center (MTOC) in muscle cells due to the accumulation of centrosomal proteins and microtubule (MT) nucleation activity at the nuclear envelope (NE) [1-4].
B. Cadot (7801451), A. Calvi (7801436), Victoria Koullourou (7797638), B. Burke (7611347), R. M. Sobota (7801433), Rutti Patel (7801439), Sue Shackleton (628446), E. R. Gomes (7801454), Y. L. Lee (3976637), J. Schmoranzer (7801448), K. Mamchaoui (7801442), P. Gimpel (7801430), F. Nédélec (7801445)   +12 more
core   +8 more sources

Analyse von Nesprin-2 defizienten Mäuse [PDF]

, 2006
Nesprin-1 and Nesprin-2 (auch Enaptin and NUANCE genannt) sind Mitglieder der α-aktinin Superfamilie, die sich durch eine Aktin-bindende Domäne, einen elongierten Bereich mit Spektrindomänen und eine C-terminale Transmembranregion auszeichnen, mit der ...
Zaim, Hafida
core   +3 more sources

Essential Role for Telomeric Repeat-Binding Factor 2 in Cardiac Development and Function. [PDF]

FASEB Bioadv
This schematic illustrates a paradigm shift in telomere biology, demonstrating that Trf2 is a mandatory orchestrator of heart development and function through pathways distinct from its canonical telomere protective role. ABSTRACT Telomere repeat‐binding factor 2 (Trf2) is essential for protecting our telomeres.
Hakim Shoushtari A, Danis A, Stoner MW, Baust J, Sebastiani A, Bugga P, Manning JR, Mushala BAS, Bhattarai N, Al Ghouleh I, Scott I, Sharifi-Sanjani M.   +11 more
europepmc   +2 more sources

Syne2b/Nesprin-2 Is Required for Actin Organization and Epithelial Integrity During Epiboly Movement in Zebrafish

Frontiers in Cell and Developmental Biology, 2021
Syne2b/nesprin-2 is a giant protein implicated in tethering the nucleus to the cytoskeleton and plays an important role in maintaining cellular architecture.
Yu-Long Li, Xiao-Ning Cheng, Tong Lu, Ming Shao, De-Li Shi, De-Li Shi   +5 more
doaj   +1 more source

Nesprins: from the nuclear envelope and beyond [PDF]

Expert Reviews in Molecular Medicine, 2013
Nuclearenvelopespectrin-repeatproteins(Nesprins), are a novel family of nuclear and cytoskeletal proteins with rapidly expanding roles as intracellular scaffolds and linkers. Originally described as proteins that localise to the nuclear envelope (NE) and establish nuclear-cytoskeletal connections, nesprins have now been found to comprise a diverse ...
Rajgor, Dipen, Shanahan, Catherine M.
openaire   +2 more sources

Force-dependent structural dynamics of the giant nesprin-2. [PDF]

Proc Natl Acad Sci U S A
The nesprin protein family serves as a critical physical bridge between the cytoskeleton–a fundamental structural scaffold and mechanotransduction hub of the cell, and the nucleus–an intriguing and emerging mechanoresponsive element. Due to the external mechanical cues and the nucleo-cytoskeletal dynamics, the nesprins are physiologically under forces.
Shang F, Zhang Y, Ye J, Zhang Z, Qi X, Chen H, Yu M, Le S.   +7 more
europepmc   +3 more sources

Culturing Keratinocytes on Biomimetic Substrates Facilitates Improved Epidermal Assembly In Vitro

Cells, 2021
Mechanotransduction is defined as the ability of cells to sense mechanical stimuli from their surroundings and translate them into biochemical signals.
Eve Hunter-Featherstone, Natalie Young, Kathryn Chamberlain, Pablo Cubillas, Ben Hulette, Xingtao Wei, Jay P. Tiesman, Charles C. Bascom, Adam M. Benham, Martin W. Goldberg, Gabriele Saretzki, Iakowos Karakesisoglou   +11 more
doaj   +1 more source

Nesprin-2 competes with RanBP2 for BICD2-CC3 binding.

, 2023
(A) Schematic representation of the assay. (B-L) A purified RanBP2 fragment (aa 2148–2240) and/or Nesprin-2 fragment (for sequence see S1A Fig) plus BICD2-CC3 (residues 711–800) were mixed at a 1:1:1 molar ratio and analyzed for physical interactions by ...
Crystal R. Noell (8097845), Julie Yi (5244398), Richard B. Vallee (2646448), Xiaoxin Zhao (698246), Paige Helmer (14808506), Sozanne R. Solmaz (4262632)   +5 more
core   +1 more source

The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal

Scientific Reports, 2021
The morphology of the Golgi complex is influenced by the cellular context, which strictly correlates with nuclear functions; however, the mechanism underlying this association remains elusive.
Miki Hieda, Taizo Matsumoto, Mari Isobe, Sadamu Kurono, Kaneko Yuka, Satoshi Kametaka, Jing-Ya Wang, Ya-Hui Chi, Kenji Kameda, Hiroshi Kimura, Nariaki Matsuura, Shuji Matsuura   +11 more
doaj   +1 more source

The Nesprin-1/-2 ortholog ANC-1 regulates organelle positioning in C. elegans independently from its KASH or actin-binding domains

eLife, 2021
KASH proteins in the outer nuclear membrane comprise the cytoplasmic half of linker of nucleoskeleton and cytoskeleton (LINC) complexes that connect nuclei to the cytoskeleton.
Hongyan Hao, Shilpi Kalra, Laura E Jameson, Leslie A Guerrero, Natalie E Cain, Jessica Bolivar, Daniel A Starr   +6 more
doaj   +1 more source