Results 61 to 70 of about 5,180,956 (219)
Birth of a Regulatory Long Non-coding RNA/Gene, linc-UR-UB
Frontiers in Genetics, 2021 The origin of genes has been a major topic of research for many years, albeit in some cases, it has been a difficult process to elucidate. Insightful is a recent publication that experimentally shows how one gene, linc-UR-UB was born.
Nicholas Delihas
doaj +1 more source
Generation and Analysis of Striated Muscle Selective LINC Complex Protein Mutant Mice [PDF]
, 2018 The linker of nucleoskeleton and cytoskeleton (LINC) complex mediates intracellular cross talk between the nucleus and the cytoplasm. In striated muscle, the LINC complex provides structural support to the myocyte nucleus and plays an essential role in ...
Ju Chen +8 more
core +1 more source
Nucleus, 2019 The linker of nucleoskeleton and cytoskeleton (LINC) complex is an essential multi-protein structure spanning the eukaryotic nuclear envelope. The LINC complex functions to maintain nuclear architecture, positioning, and mobility, along with specialized ...
Hardeep K. Gumber +6 more
doaj +1 more source
Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD
Nature Communications, 2017 Long non-coding RNAs (lncRNAs) are important regulators of diverse biological processes. Here we report on functional identification and characterization of a novel long intergenic non-coding RNA with MyoD-regulated and skeletal muscle-restricted ...
Xiaohua Yu +15 more
doaj +1 more source
LINC complex alterations in DMD and EDMD/CMT fibroblasts [PDF]
European Journal of Cell Biology, 2012 Emery-Dreifuss muscular dystrophy (EDMD) is a late onset-disease characterized by skeletal muscle wasting and heart defects with associated risk of sudden death. The autosomal dominant form of the disease is caused by mutations in the LMNA gene encoding LaminA and C, the X-linked form results from mutations in the gene encoding the inner nuclear ...
Taranum, Surayya +8 more
openaire +2 more sources
LINC complex: The link between chromatin integrity and sperm motility
, 2022 The LINC complex (Linker of the Nucleoskeleton and Cytoskeleton) is a protein structure located in the nuclear membrane that connects the cytoskeleton with the nucleoskeleton.
Šanovec, Ondřej
core
Mechanical Characterization of Glandular Acini Using a Micro-indentation Instrument
Bio-Protocol, 2020 The linker of nucleoskeleton and cytoskeleton (LINC) complex is responsible for tethering the nucleus to the cytoskeleton, providing a pathway for the cell’s nucleus to sense mechanical signals from the environment.
Christopher O'Bryan +3 more
doaj +1 more source
Advanced Materials, EarlyView.Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello +5 more
wiley +1 more source
Reactions of Terminal Olefins With Iron Carbenes
Angewandte Chemie, EarlyView.Iron carbenes react with terminal olefins and show productive metathesis or metathesis‐divergent pathways depending on the nature of the olefin. Reactions proceed through 2π + 2π cycloadditions to generate transient metallacyclobutane intermediates that undergo cycloreversion to generate the metathesis product or the metathesis‐divergent β‐hydride ...
Zachary S. Lincoln +2 more
wiley +2 more sources
Chain reaction: LINC complexes and nuclear positioning [PDF]
F1000Research, 2019 Nuclear positioning plays an essential role in defining cell architecture and behaviour in both development and disease, and nuclear location frequently adjusts according to internal and external cues. For instance, during periods of migration in many cell types, the nucleus may be actively repositioned behind the microtubule-organising centre. Nuclear
openaire +2 more sources