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Cells, 2021 The activation of microglia, the inflammatory cells of the central nervous system (CNS), has been linked to the pathogenesis of Alzheimer’s disease and other neurodegenerative diseases.
Ahmed Elbediwy, Francesca Mackenzie
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Decoding force-transmission linkages for therapeutic targeting and engineering [PDF]
APL BioengineeringMechanosensing and mechanotransduction enable cells to perceive and respond to mechanical forces, underpinning essential physiological processes and disease pathways.
Jingzhun Liu, Yunxin Deng, Jie Yan
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Multicellular Mechanoreciprocity in the Heart: Coordinated ECM Sensing and Remodeling by Cardiomyocytes, Fibroblasts, and Macrophages [PDF]
CellsThe cardiac extracellular matrix (ECM) is a dynamic, mechanically active network continuously shaped and interpreted by cardiomyocytes, fibroblasts, and macrophages.
Colleen M. Simmerly +2 more
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MSL10 is a high-sensitivity mechanosensor in the tactile sense of the Venus flytrap [PDF]
Nature CommunicationsThe tactile sense is essential for living organisms. However, the molecular mechanisms of mechanosensing in plants remain unclear. The Venus flytrap (Dionaea muscipula), a carnivorous plant, possesses mechanosensitive organs called sensory hairs.
Hiraku Suda +6 more
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Frontiers in Biomaterials ScienceThree-dimensional (3D) tissue-engineered scaffolds mimic the physiological environment of cells by providing essential structural support, biochemical cues, and the mechanical strength needed for cell adhesion, proliferation, migration, and ...
Silviya Zustiak +2 more
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iScience, 2023 Summary: The cardiac fibroblast interacts with an extracellular matrix (ECM), enabling myofibroblast maturation via a process called mechanosensing. Although in the aging male heart, ECM is stiffer than in the young mouse, myofibroblast development is ...
Aude Angelini +4 more
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Caveolae couple mechanical stress to integrin recycling and activation
eLife, 2022 Cells are subjected to multiple mechanical inputs throughout their lives. Their ability to detect these environmental cues is called mechanosensing, a process in which integrins play an important role. During cellular mechanosensing, plasma membrane (PM)
Fidel-Nicolás Lolo +8 more
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HortTechnology, 2021 Mechanical stimulation to produce stable and high-quality crops under greenhouse conditions is a promising alternative to chemical growth retardants. However, plant tissue damage and the lack of full automatization have been major constraints for large ...
Marc-André Sparke +5 more
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Mechanosensitive Regulation of Fibrosis
Cells, 2021 Cells in the human body experience and integrate a wide variety of environmental cues. A growing interest in tissue mechanics in the past four decades has shown that the mechanical properties of tissue drive key biological processes and facilitate ...
Shuying Yang, Sergey V. Plotnikov
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Implant Fibrosis and the Underappreciated Role of Myofibroblasts in the Foreign Body Reaction
Cells, 2021 Body implants and implantable medical devices have dramatically improved and prolonged the life of countless patients. However, our body repair mechanisms have evolved to isolate, reject, or destroy any object that is recognized as foreign to the ...
Nina Noskovicova +2 more
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