Results 11 to 20 of about 9,819 (199)
Emerging Topics in Life Sciences, 2018 Structural links from the nucleus to the cytoskeleton and to the extracellular environment play a role in direct mechanosensing by nuclear factors. Here, we highlight recent studies that illustrate nuclear mechanosensation processes ranging from DNA repair and nuclear protein phospho-modulation to chromatin reorganization, lipase activation by dilation,
Yuntao Xia +4 more
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Journey to the Center of the Cell: Cytoplasmic and Nuclear Actin in Immune Cell Functions
Frontiers in Cell and Developmental Biology, 2021 Actin cytoskeletal dynamics drive cellular shape changes, linking numerous cell functions to physiological and pathological cues. Mutations in actin regulators that are differentially expressed or enriched in immune cells cause severe human diseases ...
Julien Record +5 more
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Assaying mechanosensation [PDF]
WormBook, 2014 C. elegans detect and respond to diverse mechanical stimuli using neuronal circuitry that has been defined by decades of work by C. elegans researchers. In this WormMethods chapter, we review and comment on the techniques currently used to assess mechanosensory response. This methods review is intended both as an introduction for those new to the field
Martin, Chalfie +3 more
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Gels, 2021 Cell encapsulating scaffolds are necessary for the study of cellular mechanosensing of cultured cells. However, conventional scaffolds used for loading cells in bulk generally fail at low compressive strain, while hydrogels designed for high toughness ...
Zain Clapacs +7 more
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Mechanosensing and fibrosis [PDF]
Journal of Clinical Investigation, 2018 Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture and function. The failure to resolve injury and restore homeostasis gives rise to progressive fibrosis that is accompanied by persistent alterations in the mechanical environment as a consequence of pathological matrix deposition and stiffening.
Daniel J. Tschumperlin +3 more
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Generation of stress fibers through myosin-driven reorganization of the actin cortex
eLife, 2021 Contractile actomyosin bundles, stress fibers, govern key cellular processes including migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental morphogenesis. The most prominent actomyosin bundles, ventral stress fibers,
Jaakko I Lehtimäki +3 more
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Advanced Science, 2023 The development of bioelectronic neural implant technologies has advanced significantly over the past 5 years, particularly in brain–machine interfaces and electronic medicine. However, neuroelectrode‐based therapies require invasive neurosurgery and can
Alexandre Trotier +8 more
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Working a second job: Cell adhesion proteins that moonlight in the nucleus
Frontiers in Cell and Developmental Biology, 2023 Cells are adept at sensing changes in their environment, transmitting signals internally to coordinate responses to external stimuli, and thereby influencing adaptive changes in cell states and behavior.
Amanda Haage, Archana Dhasarathy
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Mechanosensing in Dendritic Cells. [PDF]
Immunol RevABSTRACT Since their discovery, dendritic cells have been recognized for their unusual capacity to sense and respond to physical stimuli within their environment. However, it took nearly two decades—and the advent of mechanobiology—to elucidate the underlying mechanisms and functional implications of this mechanical hypersensitivity ...
Calmettes V +5 more
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Genetics of Mechanosensation in the Heart [PDF]
Journal of Cardiovascular Translational Research, 2011 Mechanosensation (the ultimate conversion of a mechanical stimulus into a biochemical signal) as well as mechanotransduction (transmission of mechanically induced signals) belong to the most fundamental processes in biology. These effects, because of their dynamic nature, are particularly important for the cardiovascular system.
Buyandelger, Byambajav +6 more
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