Results 41 to 50 of about 9,819 (199)

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, EarlyView.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Mechanosensing at the Vascular Interface [PDF]

Annual Review of Biomedical Engineering, 2014
Mammals are endowed with a complex set of mechanisms that sense mechanical forces imparted by blood flow to endothelial cells (ECs), smooth muscle cells, and circulating blood cells to elicit biochemical responses through a process referred to as mechanotransduction.
John M, Tarbell, Scott I, Simon, Fitz-Roy E, Curry   +2 more
openaire   +2 more sources

Human Atrial Fibroblast Adaptation to Heterogeneities in Substrate Stiffness

Frontiers in Physiology, 2020
Fibrosis is associated with aging and many cardiac pathologies. It is characterized both by myofibroblast differentiation and by excessive accumulation of extracellular matrix proteins. Fibrosis-related tissue remodeling results in significant changes in
Ramona Emig, Ramona Emig, Ramona Emig, Callum M. Zgierski-Johnston, Callum M. Zgierski-Johnston, Friedhelm Beyersdorf, Friedhelm Beyersdorf, Bartosz Rylski, Bartosz Rylski, Ursula Ravens, Ursula Ravens, Wilfried Weber, Wilfried Weber, Peter Kohl, Peter Kohl, Peter Kohl, Maximilian Hörner, Maximilian Hörner, Rémi Peyronnet, Rémi Peyronnet   +19 more
doaj   +1 more source

Parallel Processing of Olfactory and Mechanosensory Information in the Honey Bee Antennal Lobe

Frontiers in Physiology, 2021
In insects, neuronal responses to clean air have so far been reported only episodically in moths. Here we present results obtained by fast two-photon calcium imaging in the honey bee Apis mellifera, indicating a substantial involvement of the antennal ...
Ettore Tiraboschi, Ettore Tiraboschi, Luana Leonardelli, Luana Leonardelli, Gianluca Segata, Albrecht Haase, Albrecht Haase   +6 more
doaj   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Mechanosensing in the immune response [PDF]

Seminars in Cell & Developmental Biology, 2017
Cells have a remarkable ability to sense and respond to the mechanical properties of their environment. Mechanosensing is essential for many phenomena, ranging from cell movements and tissue rearrangements to cell differentiation and the immune response.
openaire   +2 more sources

Vesicles with internal active filaments: self-organized propulsion controls shape, motility, and dynamical response

New Journal of Physics, 2019
Self-propulsion and navigation due to the sensing of environmental conditions—such as durotaxis and chemotaxis—are remarkable properties of biological cells that cannot be modeled by single-component self-propelled particles.
Clara Abaurrea-Velasco, Thorsten Auth, Gerhard Gompper   +2 more
doaj   +1 more source

Flagellar Motor Transformed: Biophysical Perspectives of the Myxococcus xanthus Gliding Mechanism

Frontiers in Microbiology, 2022
Many bacteria move on solid surfaces using gliding motility, without involvement of flagella or pili. Gliding of Myxococcus xanthus is powered by a proton channel homologous to the stators in the bacterial flagellar motor. Instead of being fixed in place
Jing Chen, Beiyan Nan
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source