Results 51 to 60 of about 9,819 (199)

Mechanosensing of substrate thickness [PDF]

Physical Review E, 2010
Structure and function of the adherent cell depend in a crucial way on its microenvironment, including the stiffness of its substrate. It is often asserted that substrate thickness (as opposed to stiffness) plays a negligible role and therefore may be considered semi-infinite.
Yu-Chun Lin, Dhananjay T. Tambe, Chan Young Park, Michael R. Wasserman, Xavier Trepat, Ramaswamy Krishnan, Guillaume Lenormand, Jeffrey J. Fredberg, James P. Butler   +8 more
openaire   +3 more sources

Field‐Programmed Anisotropy in Magneto‐Piezoelectric Composites for Material‐Encoded Mechanoperception

Advanced Materials, EarlyView.
Field‐programmed anisotropy imparts material‐level intelligence to soft composites. Magnetic torque dynamics drive magneto‐piezoelectric nanowires from random dispersion into deterministic axial alignment. The resulting hierarchical percolation networks confine electromechanical coupling to specific axes and intrinsically decouple superposed force ...
Yubin Kim, Yumin Kwon, Dabin Kim, Minsun Oh, Jin Young Jung, Dongyeong Gim, Kootak Hong, Jun Yeon Hwang, Sang‐Woo Kim, Minjeong Ha   +9 more
wiley   +1 more source

SnapShot: Mechanosensing Matrix

Cell, 2016
Cells sense and respond to properties of their microenvironment that can affect cell morphology, protein levels and localization, gene expression, and even nuclear integrity. Tissue micro-stiffness, largely influenced by extracellular matrix, varies dramatically within an organism and can be a useful parameter to both clarify and organize a wide range ...
Jerome, Irianto, Charlotte R, Pfeifer, Yuntao, Xia, Dennis E, Discher   +3 more
openaire   +2 more sources

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Mechanosensation in an adipose fin [PDF]

Proceedings of the Royal Society B: Biological Sciences, 2016
Adipose fins are found on approximately 20% of ray-finned fish species. The apparently rudimentary anatomy of adipose fins inspired a longstanding hypothesis that these fins are vestigial and lack function. However, adipose fins have evolved repeatedly within Teleostei, suggesting adaptive function.
Brett R. Aiello, Thomas A. Stewart, Melina E. Hale   +2 more
openaire   +2 more sources

Mechanobiology of Autophagy: The Unexplored Side of Cancer

Frontiers in Oncology, 2021
Proper execution of cellular function, maintenance of cellular homeostasis and cell survival depend on functional integration of cellular processes and correct orchestration of cellular responses to stresses.
Maria Paz Hernández-Cáceres, Leslie Munoz, Leslie Munoz, Javiera M. Pradenas, Javiera M. Pradenas, Francisco Pena, Francisco Pena, Pablo Lagos, Pablo Aceiton, Pablo Aceiton, Gareth I. Owen, Gareth I. Owen, Gareth I. Owen, Eugenia Morselli, Eugenia Morselli, Alfredo Criollo, Alfredo Criollo, Alfredo Criollo, Andrea Ravasio, Cristina Bertocchi   +19 more
doaj   +1 more source

FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model

Advanced Science, EarlyView.
FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble, Wiktor Zywicki, Enrico Lucarelli, Ania Naila Guerrieri, Francesca Taraballi, Gianluca Cidonio, Claudia Di Bella, Carmine Onofrillo, Andrea J. O'Connor, Serena Duchi   +9 more
wiley   +1 more source

Cyclic stretch of the substratum using a shape-memory alloy induces directional migration in Dictyostelium cells

BioTechniques, 2009
Living cells are constantly subjected to various mechanical stimulations. They must sense the mechanical aspects of their environment and respond appropriately for proper cell function. In general, cells adhere to substrata.
Yoshiaki Iwadate, Shigehiko Yumura
doaj   +1 more source

Inflammatory Cytokines Alter Mesenchymal Stem Cell Mechanosensing and Adhesion on Stiffened Infarct Heart Tissue After Myocardial Infarction

Frontiers in Cell and Developmental Biology, 2020
Mesenchymal stem cell (MSC) transplantation has demonstrated its potential in repairing infarct heart tissue and recovering heart function after myocardial infarction (MI).
Dan Zhu, Peng Wu, Peng Wu, Changchen Xiao, Wei Hu, Tongtong Zhang, Xinyang Hu, Wei Chen, Wei Chen, Jian’an Wang   +9 more
doaj   +1 more source