Results 71 to 80 of about 9,819 (199)
Developmental Dynamics, EarlyView.Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane +4 more
wiley +1 more source
Taming Variability in T-Cell Mechanosensing
CellsA central step in T-cell immunotherapy is the expansion of a starting population into therapeutically potent numbers of these “living drugs”. This process can be enhanced by replacing the mechanically stiff materials used for activation with softer ...
Paula J. Schultheiss +3 more
doaj +1 more source
Vascular Mechanobiology: Towards Control of In Situ Regeneration
Cells, 2017 The paradigm of regenerative medicine has recently shifted from in vitro to in situ tissue engineering: implanting a cell-free, biodegradable, off-the-shelf available scaffold and inducing the development of functional tissue by utilizing the ...
Eline E. van Haaften +2 more
doaj +1 more source
iMeta, EarlyView.Climate change demands accelerated plant adaptation and de novo domestication. Yet current enviromics focuses disproportionately on external environments, neglecting internal dynamics—gene expression, metabolic flux, and signal transduction—within predictive envirotyping frameworks.
Lin‐An Zhang +8 more
wiley +1 more source
Feeling Stressed or Strained? A Biophysical Model for Cell Wall Mechanosensing in Plants
Frontiers in Plant Science, 2019 Mechanical signals have recently emerged as a major cue in plant morphogenesis, notably influencing cytoskeleton organization, gene expression, protein polarity, or cell division. Although many putative mechanosensing proteins have been identified, it is
Antoine Fruleux +2 more
doaj +1 more source
Reversing brain aging: Targeting energy metabolism in endogenous neural stem cells
Interdisciplinary Medicine, EarlyView.Mechanism of endogenous neural stem cells (eNSCs) energy metabolism disorder leading to brain aging and targeted eNSCs intervention strategies (By biorender). The disorder of energy metabolism of eNSCs can lead to their resting and aging, and eventually lead to brain aging.
Chong Chen +6 more
wiley +1 more source
Emerging S100A11 roles: Regulation of focal adhesion dynamics and mechanosensing
Cell Structure and FunctionS100A11 is a small calcium-binding protein that has been studied in the context of growth regulation and membrane repair. However, it has recently been linked to the disassembly of focal adhesions.
Tareg Omer Mohammed +2 more
doaj +1 more source
Mechanosensing through immunoreceptors
Nature Immunology, 2019 The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors, whose expression and activity depend on the developmental stages of the cell and its environmental context.
Cheng Zhu +4 more
openaire +3 more sources
Frontiers in Bioscience-LandmarkCollagen, the primary structural protein of the extracellular matrix, shows marked structure–function duality in the tumor immune microenvironment (TIME). Biomechanical and biophysical alterations—matrix stiffening, viscoelastic energy dissipation, fiber
Yinxin Zhang +6 more
doaj +1 more source
VIEW, EarlyView.Dynamic immuno‐mechanobiomaterials with time‐programmed mechanical adaptation orchestrate host responses through precise mechanotransduction and immune‐stromal regulation. These adaptive biomaterials minimize mechanical mismatch, attenuate the forign dy response and fibrosis, promote angiogenesis and controlled extracellular matrix remodeling, and ...
Gobinath Vellapalayam Manoharan +4 more
wiley +1 more source