Results 81 to 90 of about 9,819 (199)

Principles and regulation of mechanosensing

Journal of Cell Science
ABSTRACT Research over the past two decades has highlighted that mechanical signaling is a crucial component in regulating biological processes. Although many processes and proteins are termed ‘mechanosensitive’, the underlying mechanisms involved in mechanosensing can vary greatly.
Stefano Sala, Alexia Caillier, Patrick W. Oakes   +2 more
openaire   +2 more sources

Cancer cells metastasize in several types of cancer via two distinct routes, probably based on mechanical signals

Frontiers in Cell and Developmental Biology
Tumor diseases pose an enormous health threat when they become malignant, as in the process of metastasis. Cancer metastasis has been extensively studied in the past, but attention has been focused primarily on the established intraluminal metastasis ...
Claudia Tanja Mierke
doaj   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Mechanosensation and transduction in osteocytes [PDF]

BoneKEy-Osteovision, 2006
There may be no single mechanoreceptor in osteocytes, but instead a combination of events that has to be triggered for mechanosensation and transduction of signal to occur. Possibilities include shear stress along dendritic processes and/or the cell body, cell deformation in response to strain, and primary cilia.
openaire   +2 more sources

Trpv4 Regulates Topography-Mediated Bone Formation Via Macrophage-Osteoclast Axis

International Dental Journal
Aim or purpose: Osteoinductive biomaterial hold great potentials in repairing segmental jaw bone defects. However, the mechanism behind remains unknown.
Jingqi Wu, Mingzheng Li
doaj   +1 more source

Reconstruction of native cellular microanatomy in a novel bioengineered full thickness human nasal mucosal construct

Journal of Anatomy, EarlyView.
Bioengineered tissue constructs are vital technologies employed in in vitro testing of both fundamental biological principles and industrial screening practices. Current approaches to modelling the nasal mucosa in vitro are not representative and are associated with limitations that impact their reliability and predictive value.
Steven Bradbury, Bethany Dickson, Nicola Curtis, David Bunton, Kirsty Goncalves, Stefan Przyborski   +5 more
wiley   +1 more source

Noxious Mechanosensation [PDF]

, 2018
Abstract This article introduces a number of critical features of mechanical transduction and neuronal sensory coding, with particular reference to mechanical pain. High threshold mechanoreceptors (HTMRs) in skin are the first relay point for the transduction of noxious mechanical force into the nervous system, and their properties ...
Delmas, Patrick, Korogod, Sergiy, Coste, Bertrand   +2 more
openaire   +2 more sources

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science
The secretory pathway is a sophisticated endomembrane machinery designed to transport and deliver proteins and lipids to intracellular organelles and the extracellular space.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. delMercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
doaj   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source