Results 101 to 110 of about 9,819 (199)

CPTCs Drive Somatic‐Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single‐Cell Deep Learning Study

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Using an interpretable deep learning framework (CARSS) applied to multi‐tissue single‐cell RNA sequencing, we identify CD34⁺PDGFRα⁺ telocytes (CPTCs) as the primary mechanosensors bridging somatic acupuncture stimulation and visceral repair. Mechanical force at acupoints activates an AP‐1/Hsp70 immediate‐early gene program in fascial CPTCs, triggering ...
Haixiang Huang, Zhenwei Zhang, Bingbing Shen, Jianming Yue, Lu Mei, Xudong Zhu, Yonghong Shi, Qianmei Zhu, Yeping Shi, Yifan Luo, Yitong Xing, Meng Dai, Qiusheng Chen   +12 more
wiley   +1 more source

Mechanosensing at the Surface [PDF]

Biophysical Journal, 2017
Skin is innervated by a rich variety of mechanosensitive neurons that trigger distinct sensations such as pressure, flutter and pain. A growing body of evidence indicates that epithelial cells actively partipate in sensation by modulating, and even directly exciting, mechanosensitive neurons in healthy skin and pathophysiological conditions.
openaire   +1 more source

Combination of 3D and 2D Small and Wide Angle X‐Ray Scattering Imaging Reveals Diminished Bone Quality in the Superior Human Femoral Neck Cortex

Advanced Materials, Volume 38, Issue 45, 13 August 2026.
Combined 2D and 3D X‐ray scattering imaging is used to analyse nanostructural properties in the inferior and superior cortex of 78 human femoral necks from 44 donors. The methodology allows for increased interpretation of nanostructure in a statistically relevant dataset, revealing nanostructural differences in anatomical locations critical to clinical
Torne Tänzer, Tatiana Kochetkova, Arthur Baroni, Mathieu Simon, Mads Carlsen, Santiago Fernandez Bordin, Manuel Guizar‐Sicairos, Philippe Zysset, Marianne Liebi   +8 more
wiley   +1 more source

Mechanical Intelligence in Bone Regeneration: Bridging Material and Cellular Memory for Enhanced Healing

Advanced Science, Volume 13, Issue 45, 13 August 2026.
Mechanical intelligence reframes bone regeneration as a time‐dependent coupling between material and cellular memory. Biomaterials store and release mechanical history, while cells retain prior cues and remodel the repair niche. Matching these memories to healing stages may guide stage‐specific scaffolds, sensing‐assisted prediction, mechanical dosing,
Jin Tian, Guoyou Huang, Yang Chen, Teng Ma, Bo Cheng, Feng Xu, XiaoKang Li, Pei Yang, Ting Wen   +8 more
wiley   +1 more source

Microgel‐Based Immunomodulatory Biomaterials for Regulating Macrophage Polarization

Journal of Biomedical Materials Research Part A, Volume 114, Issue 8, August 2026.
Macrophages are key regulators of the immune system. Modulating their phenotype from pro‐inflammatory (M1) to pro‐regenerative (M2) is key to engineering implantable tissue scaffolds for regenerative medicine. Understanding the cell‐matrix mechanosensitive trends macrophages exhibit with microgel‐based biomaterials will enhance future research.
Cody Tuftee, Muhammad Rizwan
wiley   +1 more source

Inhibiting the Endothelial Mechanosensitive Channel Piezo1 Restores Hippocampal Blood–Brain Barrier Integrity to Improve Anesthesia‐ and Surgery‐Induced Cognitive Decline

MedComm, Volume 7, Issue 8, August 2026.
Approximately 10%–30% of elderly patients develop cognitive decline after surgery. How brain regions coordinate cellular networks to mediate this remains unclear. Anesthesia/surgery induces Piezo1 in hippocampal endothelial cells of aged mice. Endothelial Piezo1 deletion restores BBB integrity and improves cognition.
Yong Qiu, Chunheng Mo, Jinyan Wu, Jiachen Li, Shiyu Xu, Lu Chen, Liyin Zhang, Xingming Huang, Yi Zhang, Meng Sun, Yi Kang, Tao Zhu, Bi‐Sen Ding, Guo Chen   +13 more
wiley   +1 more source

MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities

Cancer Science, Volume 117, Issue 8, Page 2050-2063, August 2026.
Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah, Mackenzie M. Mayhew, Jacob Sellers, Russell G. Witt   +3 more
wiley   +1 more source

Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate ALK1 Signaling in Endothelial Cells

Cells
Endothelial cells (ECs) respond to concurrent stimulation by biochemical factors and wall shear stress (SS) exerted by blood flow. Disruptions in flow-induced responses can result in remodeling issues and cardiovascular diseases, but the detailed ...
Ya-Wen Cheng, Anthony R. Anzell, Stefanie A. Morosky, Tristin A. Schwartze, Cynthia S. Hinck, Andrew P. Hinck, Beth L. Roman, Lance A. Davidson   +7 more
doaj   +1 more source

Mechanobiology in Action: Biomaterials, Devices, and the Cellular Machinery of Force Sensing

Biomolecules
Mechanical forces are increasingly recognised as fundamental regulators of cellular function, complementing classical biochemical cues to direct development, tissue homeostasis, and disease progression.
Miriam Lucariello, Maria Luisa Valicenti, Samuele Giannoni, Leonardo Donati, Ilaria Armentano, Francesco Morena, Sabata Martino   +6 more
doaj   +1 more source

Early Intervention With Biologics for Asthma Remission: Promising or Premature?

Respirology, Volume 31, Issue 8, Page 783-786, August 2026.
Santi Nolasco, Jaime Bernaola, Parameswaran Nair   +2 more
wiley   +1 more source