Results 1 to 10 of about 1,291,235 (309)

Spire stimulates nucleation by Cappuccino and binds both ends of actin filaments. [PDF]

, 2020
The actin nucleators Spire and Cappuccino synergize to promote actin assembly, but the mechanism of their synergy is controversial. Together these proteins promote the formation of actin meshes, which are conserved structures that regulate the ...
Bailey, Hannah M, Bradley, Alexander O, Quinlan, Margot E, Vizcarra, Christina L   +3 more
core  

Fundamental differences

eLife, 2018
The differences between β- and γ-actin are deeper than those between the amino acid sequences of these two proteins.
Peter W Gunning, Edna C Hardeman
doaj   +1 more source

Willin/FRMD6 Influences Mechanical Phenotype and Neuronal Differentiation in Mammalian Cells by Regulating ERK1/2 Activity

Frontiers in Cellular Neuroscience, 2020
Willin/FRMD6 is part of a family of proteins with a 4.1 ezrin-radixin-moesin (FERM) domain. It has been identified as an upstream activator of the Hippo pathway and, when aberrant in its expression, is associated with human diseases and disorders.
Nils M. Kronenberg, Nils M. Kronenberg, Andrew Tilston-Lunel, Andrew Tilston-Lunel, Frances E. Thompson, Doris Chen, Wanjia Yu, Kishan Dholakia, Kishan Dholakia, Malte C. Gather, Malte C. Gather, Frank J. Gunn-Moore   +11 more
doaj   +1 more source

Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p. [PDF]

, 2014
The exocyst serves to tether secretory vesicles to cortical sites specified by polarity determinants, in preparation for fusion with the plasma membrane.
Liu, Dongmei, Novick, Peter
core   +1 more source

Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons

eLife, 2014
In the vertebrate central nervous system, exploratory filopodia transiently form on dendritic branches to sample the neuronal environment and initiate new trans-neuronal contacts.
Milos Galic, Feng-Chiao Tsai, Sean R Collins, Maja Matis, Samuel Bandara, Tobias Meyer   +5 more
doaj   +1 more source

Steric regulation of tandem calponin homology domain actin-binding affinity. [PDF]

, 2019
Tandem calponin homology (CH1-CH2) domains are common actin-binding domains in proteins that interact with and organize the actin cytoskeleton. Despite regions of high sequence similarity, CH1-CH2 domains can have remarkably different actin-binding ...
Bausch, Andreas, Belardi, Brian, Fletcher, Daniel A, Harris, Andrew R, Jreij, Pamela, Shams, Hengameh, Wei, Kathy   +6 more
core   +1 more source

Stress relaxation in F-actin solutions by severing

, 2019
Networks of filamentous actin (F-actin) are important for the mechanics of most animal cells. These cytoskeletal networks are highly dynamic, with a variety of actin-associated proteins that control cross-linking, polymerization and force generation in ...
Arzash, S., Feng, J., Gardel, M. L., MacKintosh, F. C., McCall, P. M.   +4 more
core   +1 more source

Actin filament assembly by bacterial factors VopL/F: Which end is up? [PDF]

, 2017
Competing models have been proposed for actin filament nucleation by the bacterial proteins VopL/F. In this issue, Burke et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608104) use direct observation to demonstrate that VopL/F bind the barbed ...
Bosch, Burke, Chen, Christina L. Vizcarra, Dominguez, Margot E. Quinlan, Namgoong, Pernier, Quinlan, Tam, Yu, Zahm   +11 more
core   +1 more source

Vitamin D Binding Protein: A Historic Overview

Frontiers in Endocrinology, 2020
Vitamin D and all its metabolites are bound to a specific vitamin D binding protein, DBP. This protein was originally first discovered by its worldwide polymorphism and called Group-specific Component (GC).
Roger Bouillon, Frans Schuit, Leen Antonio, Leen Antonio, Fraydoon Rastinejad   +4 more
doaj   +1 more source

How contraction has shaped evolution

eLife, 2019
Two unicellular relatives of animals reveal that coordinated contractions of groups of cells using actomyosin predated animal multicellularity during evolution.
Mukund Thattai
doaj   +1 more source