Results 11 to 20 of about 1,019,729 (309)

mDia1 Assembles a Linear F-Actin Coat at Membrane Invaginations To Drive Listeria monocytogenes Cell-to-Cell Spreading

mBio, 2021
Direct cell-to-cell spreading of Listeria monocytogenes requires the bacteria to induce actin-based finger-like membrane protrusions in donor host cells that are endocytosed through caveolin-rich membrane invaginations by adjacent receiving cells.
Aaron S. Dhanda, A. Wayne Vogl, Fern Ness, Metello Innocenti, Julian A. Guttman   +4 more
doaj   +1 more source

Frequent Manipulation of Resistance Training Variables Promotes Myofibrillar Spacing Changes in Resistance-Trained Individuals

Frontiers in Physiology, 2021
We sought to determine if manipulating resistance training (RT) variables differentially altered the expression of select sarcoplasmic and myofibril proteins as well as myofibrillar spacing in myofibers.
Carlton D. Fox, Paulo H. C. Mesquita, Joshua S. Godwin, Vitor Angleri, Felipe Damas, Bradley A. Ruple, Casey L. Sexton, Michael D. Brown, Andreas N. Kavazis, Kaelin C. Young, Kaelin C. Young, Carlos Ugrinowitsch, Cleiton A. Libardi, Michael D. Roberts, Michael D. Roberts   +14 more
doaj   +1 more source

SUMOylation of nuclear actin [PDF]

, 2009
Actin, a major component of the cytoplasm, is also abundant in the nucleus. Nuclear actin is involved in a variety of nuclear processes including transcription, chromatin remodeling, and intranuclear transport.
Alessandro Arduini, Lessard, James L., Arduini, Alessandro, Nicol, Samantha M., Fuller-Pace, Frances V., Primal de Lanerolle, Samantha M. Nicol, Frances V. Fuller-Pace, Carlos J. Camacho, James L. Lessard, de Lanerolle, Primal, Wilma A. Hofmann, Camacho, Carlos J., Hofmann, Wilma A.   +13 more
core   +1 more source

Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42 [PDF]

Open Biology, 2020
Focal adhesion kinase (FAK) mediates vital cellular pathways during development. Despite its necessity, how FAK regulates and integrates with other signals during early embryogenesis remains poorly understood.
I-Chen Hung, Tsung-Ming Chen, Jing-Ping Lin, Yu-Ling Tai, Tang-Long Shen, Shyh-Jye Lee   +5 more
doaj   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F-actin distribution. [PDF]

FEBS Open Bio
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Joseph TV, Pham AB, Bornes KE, Hammad RH, Rousseve-Ross CA, Huckaba TM, Watt TJ, Toro TB.   +7 more
europepmc   +2 more sources

Identification of the Antifungal Metabolite Chaetoglobosin P From Discosia rubi Using a Cryptococcus neoformans Inhibition Assay: Insights Into Mode of Action and Biosynthesis

Frontiers in Microbiology, 2020
Cryptococcus neoformans is an important human pathogen with limited options for treatments. We have interrogated extracts from fungal fermentations to find Cryptococcus-inhibiting natural products using assays for growth inhibition, differential ...
Bruno Perlatti, Connie B. Nichols, Nan Lan, Philipp Wiemann, Colin J. B. Harvey, J. Andrew Alspaugh, Gerald F. Bills   +6 more
doaj   +1 more source

Interactions between β-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders

Frontiers in Endocrinology, 2023
β-arrestins, which have multiple cellular functions, were initially described as proteins that desensitize rhodopsin and other G protein-coupled receptors.
Tibor Szénási, Gábor Turu, Gábor Turu, László Hunyady, László Hunyady   +4 more
doaj   +1 more source

Repetitive N-WASP–binding elements of the Enterohemorrhagic Escherichia coli Effector EspFU Synergistically Activate Actin Assembly [PDF]

, 2008
Enterohemorrhagic Escherichia coli (EHEC) generate F-actin–rich adhesion pedestals by delivering effector proteins into mammalian cells. These effectors include the translocated receptor Tir, along with EspFU, a protein that associates indirectly with ...
McGhie, E.J., Rosen, M.K., Kenneth G Campellone, Robbins, D., Cheng, HC, Robbins, D, Rosen, MK, Koronakis, V, John M Leong, Siripala, AD, Michael K Rosen, Koronakis, V., McGhie Emma J., Leong, JM, Hayward Richard D., Welch, MD, Campellone Kenneth G., Robbins Douglas, Campellone, K.G., Anosha D Siripala, Cheng, H.-C., Leong, J.M., Leong John M., Hui-Chun Cheng, Emma J McGhie, Cheng Hui-Chun, Hayward, RD, Richard D Hayward, Siripala Anosha D., Welch, M.D., Siripala, A.D., Hayward, Richard D., Douglas Robbins, Vassilis Koronakis, Galán, J.E., Campellone, KG, McGhie, EJ, Matthew D Welch, Rosen Michael K., Koronakis Vassilis, Welch Matthew D., Cheng, Hui-Chun, Robbins, Douglas, Siripala, Anosha D., Koronakis, Vassilis, Campellone, Kenneth Geno, Welch, Matthew D., McGhie, Emma J., Rosen, Michael K., Leong, John M.   +49 more
core   +1 more source

Mechanics and regulation of cytokinetic abscission

Frontiers in Cell and Developmental Biology, 2022
Cytokinetic abscission leads to the physical cut of the intercellular bridge (ICB) connecting the daughter cells and concludes cell division. In different animal cells, it is well established that the ESCRT-III machinery is responsible for the ...
Virginia Andrade, Virginia Andrade, Arnaud Echard   +2 more
doaj   +1 more source

Actin Remodeling Defects Leading to Autoinflammation and Immune Dysregulation

Frontiers in Immunology, 2021
A growing number of monogenic immune-mediated diseases have been related to genes involved in pathways of actin cytoskeleton remodeling. Increasing evidences associate cytoskeleton defects to autoinflammatory diseases and primary immunodeficiencies.
Riccardo Papa, Federica Penco, Stefano Volpi, Marco Gattorno   +3 more
doaj   +1 more source