Results 21 to 30 of about 12,439 (207)

mDia1 senses both force and torque during F-actin filament polymerization

Nature Communications, 2017
Formins are actin-polymerisation factors that are sensitive to force. Here the authors find that pulling force on an actin filament promoted faster actin polymerisation by the formin mDia1, and also found that the actin filament must be torsionally ...
Miao Yu, Xin Yuan, Chen Lu, Shimin Le, Ryo Kawamura, Artem K. Efremov, Zhihai Zhao, Michael M. Kozlov, Michael Sheetz, Alexander Bershadsky, Jie Yan   +10 more
doaj   +1 more source

Leveraging mechanobiology and biophysical cues in lung organoids for studying lung development and disease

Frontiers in Chemical Engineering, 2023
Lung organoids have emerged as powerful tools for studying lung distal diseases by recapitulating the cellular diversity and microenvironment of the lung tissue. This review article highlights the advancements in leveraging mechanobiology and biophysical
Ziming Shao, Paolo De Coppi, Paolo De Coppi, Federica Michielin   +3 more
doaj   +1 more source

Syncytial germline architecture is actively maintained by contraction of an internal actomyosin corset

Nature Communications, 2018
Germline cells in many species are fused to form a syncytium but the mechanics behind the maintenance of these structures are poorly defined. Here, the authors propose an inner contractile actomyosin corset provides a supportive framework to maintain ...
Agarwal Priti, Hui Ting Ong, Yusuke Toyama, Anup Padmanabhan, Sabyasachi Dasgupta, Matej Krajnc, Ronen Zaidel-Bar   +6 more
doaj   +1 more source

Optogenetic control of YAP can enhance the rate of wound healing

Cellular & Molecular Biology Letters, 2023
Background Tissues need to regenerate to restore function after injury. Yet, this regenerative capacity varies significantly between organs and between species.
Pearlyn Jia Ying Toh, Marius Sudol, Timothy Edward Saunders   +2 more
doaj   +1 more source

Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

Nature Communications, 2019
Fiolopodia are involved in cell migration and their attachment to the ECM is mediated by integrin receptors. Here the authors show that myosin X induced filipodia adhesion to fibronectin requires activity of myosin IIA at the filopodium base and formin ...
N. O. Alieva, A. K. Efremov, S. Hu, D. Oh, Z. Chen, M. Natarajan, H. T. Ong, A. Jégou, G. Romet-Lemonne, J. T. Groves, M. P. Sheetz, J. Yan, A. D. Bershadsky   +12 more
doaj   +1 more source

Elastomeric Pillar Cages Modulate Actomyosin Contractility of Epithelial Microtissues by Substrate Stiffness and Topography

Cells, 2023
Cell contractility regulates epithelial tissue geometry development and homeostasis. The underlying mechanobiological regulation circuits are poorly understood and experimentally challenging.
Lisann Esser, Ronald Springer, Georg Dreissen, Lukas Lövenich, Jens Konrad, Nico Hampe, Rudolf Merkel, Bernd Hoffmann, Erik Noetzel   +8 more
doaj   +1 more source

Platelet Mechanobiology Inspired Microdevices: From Hematological Function Tests to Disease and Drug Screening

Frontiers in Pharmacology, 2022
Platelet function tests are essential to profile platelet dysfunction and dysregulation in hemostasis and thrombosis. Clinically they provide critical guidance to the patient management and therapeutic evaluation.
Yingqi Zhang, Yingqi Zhang, Yingqi Zhang, Fengtao Jiang, Yunfeng Chen, Yunfeng Chen, Lining Arnold Ju, Lining Arnold Ju, Lining Arnold Ju   +8 more
doaj   +1 more source

Mechanobiology of portal hypertension

JHEP Reports, 2023
The interplay between mechanical stimuli and cellular mechanobiology orchestrates the physiology of tissues and organs in a dynamic balance characterized by constant remodelling and adaptative processes. Environmental mechanical properties can be interpreted as a complex set of information and instructions that cells read continuously, and to which ...
Eric Felli, Sonia Selicean, Sergi Guixé-Muntet, Cong Wang, Jaume Bosch, Annalisa Berzigotti, Jordi Gracia-Sancho   +6 more
openaire   +2 more sources

Myosin 1E localizes to actin polymerization sites in lamellipodia, affecting actin dynamics and adhesion formation

Biology Open, 2013
Summary Because the actin network in active lamellipodia is continuously assembling at the edge, moving inward and disassembling, there is a question as to how actin-binding proteins and other components are transported to the leading edge and how ...
Prabuddha Gupta, Nils C. Gauthier, Yu Cheng-Han, Yuan Zuanning, Bruno Pontes, Malte Ohmstede, René Martin, Hans-Joachim Knölker, Hans-Günther Döbereiner, Mira Krendel, Michael Sheetz   +10 more
doaj   +1 more source

Mechanobiology

International Journal For Multidisciplinary Research
Mechanobiology is an emerging field of multidisciplinary research studying how the physical properties of the cell environment and mechanical loads regulate biological processes at the cellular, tissue, and molecular levels. It adopts ideas from physics, biology, and engineering to comprehend how cells sense, translate, and respond to mechanical ...
Magham Ramachandra, Shaik Ul Haq, Dornala Dixit   +2 more
  +4 more sources