Results 71 to 80 of about 40,337 (298)

Substrate stiffness controls proinflammatory responses in human gingival fibroblasts

Scientific Reports, 2023
Soft gingiva is often compromised in gingival health; however, the underlying biological mechanisms remain unknown. Extracellular matrix (ECM) stiffness is involved in the progression of various fibroblast-related inflammatory disorders via cellular ...
Watcharaphol Tiskratok, Masahiro Yamada, Jun Watanabe, Nadia Kartikasari, Tsuyoshi Kimura, Hiroshi Egusa   +5 more
doaj   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Flow-dependent mass transfer may trigger endothelial signaling cascades. [PDF]

PLoS ONE, 2012
It is well known that fluid mechanical forces directly impact endothelial signaling pathways. But while this general observation is clear, less apparent are the underlying mechanisms that initiate these critical signaling processes. This is because fluid
Prashanthi Vandrangi, Martha Sosa, John Y-J Shyy, Victor G J Rodgers   +3 more
doaj   +1 more source

Injury-mediated stiffening persistently activates muscle stem cells through YAP and TAZ mechanotransduction

Science Advances, 2021
Skeletal muscle stiffening after injury induces proliferation and activation of muscle stem cells via YAP and TAZ signaling. The skeletal muscle microenvironment transiently remodels and stiffens after exercise and injury, as muscle ages, and in ...
Jason S. Silver, K. A. Günay, Alicia A. Cutler, T. Vogler, T. Brown, B. Pawlikowski, Olivia J. Bednarski, Kendra L. Bannister, Cameron J. Rogowski, A. G. McKay, F. DelRio, B. Olwin, K. Anseth   +12 more
semanticscholar   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis

Journal of Cellular and Molecular Medicine, 2020
Mechanical stress plays a critical role in cartilage development and homoeostasis. Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs dynamic and static forces and transmits them to the chondrocyte surface.
Zhenxing Zhao, Yifei Li, Mengjiao Wang, Sen Zhao, Zhi-Qin Zhao, J. Fang   +5 more
semanticscholar   +1 more source

Cardiac‐Derived ECM Microspheres for Enhanced hiPSC‐CMs Maturation

Advanced Functional Materials, EarlyView.
Cardiac extracellular matrix microspheres derived from decellularized porcine heart provide a biomimetic 3D microenvironment for human induced pluripotent stem cell–derived cardiomyocytes (hiPSC‐CMs). This platform supports short‐ and long‐term culture, enhances structural organization, and promotes electrophysiological and functional maturation of ...
Jiazhu Xu, Joel Aboagye, Marcella Edwards, Nick Rogozinski, Yufeng Wen, Angello Huerta Gomez, Zui Pan, Ge Zhang, Huaxiao Yang, Yi Hong   +9 more
wiley   +1 more source

Mechanism and application of feedback loops formed by mechanotransduction and histone modifications

Genes and Diseases
Mechanical stimulation is the key physical factor in cell environment. Mechanotransduction acts as a fundamental regulator of cell behavior, regulating cell proliferation, differentiation, apoptosis, and exhibiting specific signature alterations during ...
Han Sun, Yafang Gao, Xinyu Ma, Yizhou Deng, Lintao Bi, Lisha Li   +5 more
doaj   +1 more source

YAP-mediated mechanotransduction tunes the macrophage inflammatory response

Science Advances, 2020
Macrophages sense biophysical cues in the microenvironment via YAP to tune their inflammatory response. Macrophages are innate immune cells that adhere to the extracellular matrix within tissues.
V. Meli, Hamza Atcha, P. K. Veerasubramanian, Raji R. Nagalla, Thuy U. Luu, E. Y. Chen, C. Guerrero-Juarez, Kosuke Yamaga, William Pandori, J. Hsieh, T. Downing, D. Fruman, Melissa B. Lodoen, M. Plikus, Wenqi Wang, Wendy F. Liu   +15 more
semanticscholar   +1 more source

The keratin network of intermediate filaments regulates keratinocyte rigidity sensing and nuclear mechanotransduction

Science Advances, 2021
Keratin defects associated with blistering skin diseases alter force transmission to the nucleus. The keratin network of intermediate filaments provides keratinocytes with essential mechanical strength and resilience, but the contribution to ...
A. Laly, K. Sliogeryte, Oscar J. Pundel, R. Ross, M. C. Keeling, Deepa Avisetti, A. Waseem, Núria Gavara, J. Connelly   +8 more
semanticscholar   +1 more source